4 results match your criteria: "Mianyang Maternity and Child Healthcare Hospital[Affiliation]"
Newborn concurrent hearing and genetic screening for hearing impairment: A systematic review and meta‑analysis.
Exp Ther Med
September 2024
Department of Clinical Laboratory, Mianyang Maternity and Child Healthcare Hospital, Mianyang, Sichuan 621000, P.R. China.
Hearing loss is the most prevalent neurosensory disorder in humans, with significant implications for language, social and cognitive development if not diagnosed and treated early. The present systematic review and meta-analysis aimed to determine the rate of hearing screening pass and genetic screening failure [universal newborn hearing screening (UNHS) pass/genetic failure] and to investigate the advantages of combining newborn hearing and genetic screening for newborn hearing impairment. The PubMed, Embase and Cochrane databases were searched from inception to September 2023 to identify studies reporting the combination of neonatal hearing screening with genetic screening.
View Article and Find Full Text PDFPredictive value of fluorometric method and tandem mass spectrometry for hyperphenylalaninemia and its subtypes in China: A systematic review and meta‑analysis.
Exp Ther Med
July 2024
Department of Clinical Laboratory, Mianyang Maternity and Child Healthcare Hospital, Mianyang, Sichuan 621000, P.R. China.
Article Synopsis
- The study conducted a meta-analysis to evaluate the effectiveness of fluorometric assays and tandem mass spectrometry (MS/MS) in diagnosing hyperphenylalaninemia (HPA) in newborns, utilizing data from PubMed, Embase, and the Cochrane Library.
- The findings indicated that the positive predictive value (PPV) of HPA screening was significantly higher for MS/MS at 31.8% compared to 8.3% for fluorometric assays.
- Additionally, the analysis revealed that most HPA patients had phenylalanine hydroxylase deficiency (PAHD) at 88.65%, while only 12.43% had tetrahydrobiopterin deficiency (BH4D), highlighting
High-Fat Diet-Related Obesity Promotes Urethane-Induced Lung Tumorigenesis in C57BL/6J Mice.
Front Oncol
February 2021
Center for Lipid Research, Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, China.
Epidemiological studies have recently shown that obesity increases lung cancer risk, but the underlying biological connection is unclear. To determine whether high-fat diet (HFD)-induced obesity influences the susceptibility to chemical-induced lung tumorigenesis, a HFD feeding condition was combined with a multi-dose urethane-induced lung tumorigenesis model using C57BL/6J mice. In cell culture models, lung cancer cell lines A549 and H460 were used to investigate the effect of leptin on cell viability and its underlying mechanism of action.
View Article and Find Full Text PDFTargeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy.
Biol Open
November 2020
Center for Lipid Research, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Chongqing Medical University, Chongqing 400016, P.R. China
This study investigated the pathophysiological role of GRP78 in the survival of lung cancer cells. Lung cancer patient data from public databases were used to analyze the expression of GRP78 and its influence on prognoses. , GRP78 protein expression was analyzed in an established urethane-induced lung tumor mouse model.
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