Repurposing the Antidiabetic Drugs Glyburide, Gliquidone, and Glipizide in Combination with Benznidazole for Infection.

Infection with the protozoan parasite causes human Chagas disease. Benznidazole (BNZ) and nifurtimox are the current drugs for the treatment; however, they induce severe adverse side effects in patients; therefore, there is a need to improve the treatment effectiveness and efficiency of these drugs for its safer use. : Glyburide, glipizide, and gliquidone, hypoglycemic drugs for diabetes treatment, were previously predicted to bind to dihydrofolate reductase-thymidylate synthase from by in silico docking analysis; they also showed antiproliferative effects against epimastigotes, the stage of the insect vector.

Understanding the Molecular Mechanisms of Incomptine A in Treating Non-Hodgkin Lymphoma Associated with U-937 Cells: Bioinformatics Approaches, Part I.

: Incomptine A () has been reported to have cytotoxic activity in non-Hodgkin lymphoma cancer cell lines and have effects on U-937 cells, including the induction of apoptosis, the production of reactive oxygen species, and the inhibition of glycolytic enzymes. Also, has cytotoxic activity in the triple-negative subtypes, HER2+, and luminal A of breast cancer cells, with its properties being associated with an effect on the antiapoptotic function of Hexokinase II (HKII). : In this research, we reviewed the altered levels of proteins present in the lymph nodes of male Balb/c mice inoculated with U-937 cells and treated with or methotrexate, as well as mice only inoculated with cancer cells.

Molecular Markers for the Phylogenetic Reconstruction of : A Quantitative Review.

is the parasite responsible for Chagas disease, which has a significant amount of genetic diversification among the species complex. Many efforts are routinely made to characterize the genetic lineages of circulating in a particular geographic area. However, the genetic loci used to typify the genetic lineages of have not been consistent between studies.

Risk Factors Associated with Hemoparasites in Dual-Purpose Cattle of Colombia.

Hemoparasitic diseases represent a significant problem with a considerable impact on tropical and subtropical areas of the world. These conditions cause economic losses associated with multi-organic failure and even the death of animals. In these areas, the hemoparasites are transmitted in an enzootic cycle when infectious cattle, such as persistently infected animals, including cows, contribute to the success of transmission.

Theoretical Study of Sphingomyelinases from and Sheds Light on the Evolution of Enzymes Needed for Survival and Colonization.

The path to survival for pathogenic organisms is not straightforward. Pathogens require a set of enzymes for tissue damage generation and to obtain nourishment, as well as a toolbox full of alternatives to bypass host defense mechanisms. Our group has shown that the parasitic protist encodes for 14 sphingomyelinases (SMases); one of them (acid sphingomyelinase 6, aSMase6) is involved in repairing membrane damage and exhibits hemolytic activity.

Field-Programmable Gate Array (FPGA)-Based Lock-In Amplifier System with Signal Enhancement: A Comprehensive Review on the Design for Advanced Measurement Applications.

Lock-in amplifiers (LIAs) are critical tools in precision measurement, particularly for applications involving weak signals obscured by noise. Advances in signal processing algorithms and hardware synthesis have enabled accurate signal extraction, even in extremely noisy environments, making LIAs indispensable in sensor applications for healthcare, industry, and other services. For instance, the electrical impedance measurement of the human body, organs, tissues, and cells, known as bioelectrical impedance, is commonly used in biomedical and healthcare applications because it is non-invasive and relatively inexpensive.

Innovative Driver Monitoring Systems and On-Board-Vehicle Devices in a Smart-Road Scenario Based on the Internet of Vehicle Paradigm: A Literature and Commercial Solutions Overview.

In recent years, the growing number of vehicles on the road have exacerbated issues related to safety and traffic congestion. However, the advent of the Internet of Vehicles (IoV) holds the potential to transform mobility, enhance traffic management and safety, and create smarter, more interconnected road networks. This paper addresses key road safety concerns, focusing on driver condition detection, vehicle monitoring, and traffic and road management.

Comparison of Manual, Automatic, and Voice Control in Wheelchair Navigation Simulation in Virtual Environments: Performance Evaluation of User and Motion Sickness.

Mobility is essential for individuals with physical disabilities, and wheelchairs significantly enhance their quality of life. Recent advancements focus on developing sophisticated control systems for effective and efficient interaction. This study evaluates the usability and performance of three wheelchair control modes manual, automatic, and voice controlled using a virtual reality (VR) simulation tool.

Motion Smoothness Analysis of the Gait Cycle, Segmented by Stride and Associated with the Inertial Sensors' Locations.

Portable monitoring devices based on Inertial Measurement Units (IMUs) have the potential to serve as quantitative assessments of human movement. This article proposes a new method to identify the optimal placements of the IMUs and quantify the smoothness of the gait. First, it identifies gait events: foot-strike (FS) and foot-off (FO).

Prototype of a Spring-Loaded Module for Axillary Crutches.

Axillary crutches assist people with lower limb injuries but can lead to upper limb strain with extended use. Spring-loaded crutches offer a potential solution, yet they are rarely tested in clinical settings. This study developed spring-loaded crutches with an integrated force-measuring system to analyze gait dynamics.

Infections: Bridging Clinical Observations and Epidemiological Insights.

Purpose: is the main etiologic agent implicated in primary amoebic meningoencephalitis (PAM). It is also known as the brain-eating amoeba because of the severe brain inflammation following infection, with a survival rate of about 5%. This review aims to identify infections and evaluate patients' progression.

Anticonvulsant Effects of Synthetic -(3-Methoxybenzyl)oleamide and -(3-Methoxybenzyl)linoleamide Macamides: An In Silico and In Vivo Study.

Epilepsy is a chronic neurological disorder that affects nearly 50 million people worldwide. Experimental evidence suggests that epileptic neurons are linked to the endocannabinoid system and that inhibition of the FAAH enzyme could have neuroprotective effects by increasing the levels of endogenous endocannabinoid anandamide. In this context, the use of macamides as therapeutic agents in neurological diseases has increased in recent years.

Effect of Drying Methods on the Phenolic Profile and Antioxidant Capacity of (Roxb.) Benth. Aril and Its Inhibitory Properties on Human SW480 Colon Adenocarcinoma Cells.

() is a Mexican plant that is consumed raw or in different preparations, and its anti-inflammatory and antioxidant properties have traditionally been useful in treating several conditions. However, the post-harvest drying process can alter the content of bioactive compounds in . This study aims to evaluate the impact of different drying methods on the phenolic profile and antioxidant capacity of this plant, as well as its inhibitory effect on human SW480 colon adenocarcinoma cells.

Spatial-Temporal Dynamics of Adventitious Roots of Pers. Seedlings Grown with Auxin/Cytokinin.

The spatial-temporal dynamics of an in vitro radicular system of for the development of rhizofiltration technologies, with the potential for use as a phytotreatment of eutrophicated water, were studied for the first time in the roots of seedlings and in rhizotron systems. The effect of indole-3-acetic acid (AIA) in combination with kinetin (CIN) or 6-benzylaminopurine (BAP) on seedlings cultivated in the light and dark in three radicular systems and in a rhizotrophic regime for the screening of dynamic rhizogenic lines, by weekly allometric measurements of the length and number of roots, were studied. Inhibition of the elongation and branching velocities of roots by BAP and light was observed but CIN increased elongation and branching.

Impact of the Ketogenic Diet on Neurological Diseases: A Review.

Background: The ketogenic diet (KD), high in fat and low in carbohydrates, was introduced in the 1920s as a non-pharmacological treatment for refractory epilepsy. Although its mechanism of action is not fully understood, beneficial effects have been observed in neurological diseases such as epilepsy, Alzheimer's disease, and Parkinson's disease.

Objective: This review examines the impact of the ketogenic diet and its molecular and neuroglial effects as a complementary therapy for neurological diseases.

Copepod Lipidomics: Fatty Acid Substituents of Structural Lipids in , a Dominant Species in the Food Chain of the Apalachicola Estuary of the Gulf of Mexico.

Zooplanktonic copepods represent a major biological mass in the marine food chain that can be affected by climate change. Monitoring the health of this critical biomass is essential for increasing our understanding of the impact of environmental changes on marine environments. Since the lipidomes of marine organisms are known to adapt to alterations in pH, temperature, and availability of metabolic precursors, lipidomics is one technology that can be used for monitoring copepod adaptations.

Genotypes of spp. as a Source of Natural Products with Biological Activity.

The genus P. Br. (Cucurbitaceae) includes ten species, two of which are edible.

Sonochemical Functionalization of SiO Nanoparticles with Citric Acid and Monoethanolamine and Its Remarkable Effect on Antibacterial Activity.

Nanoparticles (NPs) are excellent antibacterial agents due to their ability to interact with microorganisms at the cellular level. However, their antimicrobial capacity can be limited by their tendency to agglomerate. Functionalizing NPs with suitable ligands improves their stability and dispersion in different media and enhances their antibacterial activity.

Development of Tailored Porous Ti6Al4V Materials by Extrusion 3D Printing.

Nowadays, metallic bone replacement is in high demand due to different issues, like sicknesses and accidents. Thus, bone implants are fabricated with tailored properties and microstructure for long-term use in the human body. To improve such implants, 3D printing is the most promising technique.

Evaluation of Silver Recovery from High-Sulphur Mining Waste Using Thiourea-Oxalate System.

Mine tailings are a byproduct of mineral extraction and often pose an environmental challenge due to the contamination of soil and water bodies with dissolved metals. However, this type of waste offers the opportunity for the recovery of valuable metals such as silver (Ag). In the present investigation, an integral analysis of a sample of tailings was carried out, addressing granulometry, elemental composition, neutralization potential (NP), and acid potential (AP), as well as mineralogy, for the dissolution of silver from this type of waste.

Effects of Thickness of the Corn Seed Coat on the Strength of Processed Biological Materials.

The strength and energy of processed biological materials depend, among others, on their properties. Despite the numerous studies available, the relationship between the internal structure of corn grains and their mechanical properties has not yet been explained. Hence, the aim of the work is to explore the relationship between the internal composition of maize kernels and its mechanical properties by studying the impact of the maize seed coat thickness on its breakage susceptibility.

Advancing Food Security with Farmed Edible Insects: Economic, Social, and Environmental Aspects.

Farmed edible insects are considered a potential resource to help address food security concerns toward the year 2050. The sustainability (e.g.

Searching for More Effective Food Baits for Tephritid Fruit Flies (Diptera: Tephritidae): Performance of Newly Developed Vial-Lures Relative to Torula Yeast Borax.

Food-baited traps are an important part of early detection programs for invasive tephritid fruit fly species, as they are attractive to both sexes of all targeted species. Torula yeast borax (TYB) mixture is a standard food bait, but its longevity is limited (1-2 weeks). Synthetic food-based lures have been developed, including ammonium acetate, putrescine, and trimethylamine.

Repellency of Essential Oils and Plant-Derived Compounds Against Mosquitoes.

Plant-based oils have a long history of use as insect repellents. In an earlier study, we showed that in a 10% concentration, geraniol, 2-phenylethl propionate, and the plant-based essential oils clove and cinnamon effectively protected from mosquito bites for over 60 min. To expand on this study, we reanalyzed our GC-MS data to identify the short organic constituents of these oils.