PLoS One
January 2025
Instituto de Biología, Universidad Nacional Autónoma de México (UNAM), México City, México.
Dogs can discriminate between people infected with SARS-CoV-2 from those uninfected, although their results vary depending on the settings in which they are exposed to infected individuals or samples of urine, sweat or saliva. This variability likely depends on the viral load of infected people, which may be closely associated with physiological changes in infected patients. Determining this viral load is challenging, and a practical approach is to use the cycle threshold (Ct) value of a RT-qPCR test.
View Article and Find Full Text PDFAm J Biol Anthropol
January 2025
School of Anthropology and Archaeology, The Australian National University, Canberra, Australian Capital Territory, Australia.
Introduction: Adverse experiences leading to physiological disruptions (stress) in early life produce cascade effects on various biological systems, including the endocrine and metabolic systems, which, in turn, shape the developing skeletal system. To evaluate the effects of stress on adipose and skeletal tissues, we examine the relationship between skeletal indicators of stress (porotic hyperostosis [PH] and cribra orbitalia [CO]), bone mineral density (BMD), vertebral neural canal (VNC) diameters, and adipose tissue distribution in a contemporary pediatric autopsy sample.
Methods: Data is from 702 (409 males, 293 females) individuals from a pediatric (0.
Int J Rheum Dis
January 2025
Rheumatology Department, Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, Mexico.
PeerJ
January 2025
Facultad de Ingeniería Química, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, Mexico.
The average annual water availability worldwide is approximately 1,386 trillion cubic hectometers (hm), of which 97.5% is saltwater and only 2.5% is freshwater.
View Article and Find Full Text PDFPeerJ
January 2025
Facultad de Ciencias, Universidad Autónoma del Estado de México, Toluca, Estado de México, Mexico.
Heterogeneous environments provide different daily and seasonal thermal conditions for snakes, resulting in temporal and spatial variations in body temperature (Tb). This study analyzes the Tb of in the forest and grassland of a Mexican locality through daily and seasonal profiling. The patterns were obtained from seminatural enclosures in the field with a point sampling strategy to analyze temporal and spatial variations in Tb.
View Article and Find Full Text PDFKidney Med
August 2024
School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
Originally developed for use in type 2 diabetes mellitus (T2DM), sodium-glucose co-transporter-2 (SGLT2) inhibitors demonstrated diverse cardiovascular- and kidney-protective effects in large outcome trials. Their subsequent approval as a treatment for chronic kidney disease (CKD) marked a pivotal shift in the landscape of CKD management. Further to this, the approval of dapagliflozin and empagliflozin for use in patients with CKD with and without T2DM afforded new treatment opportunities for this population.
View Article and Find Full Text PDFBackground: Right ventricular pseudoaneurysms are extremely rare and there is no precise recommendation for their management.
Case Summary: We present the case of a successful coil embolization of a right ventricular pseudoaneurysm in a woman with chronic kidney disease due to perinuclear antineutrophil cytoplasmic antibody vasculitis and a history of difficult placement of a hemodialysis catheter.
Discussion: Ventricular pseudoaneurysm is a contained rupture of the ventricular wall that can occur due to several causes.
JACC Case Rep
December 2024
Cardiology Hospital, XXI Century National Medical Center, Mexican Social Security Institute, Mexico City, Mexico.
Pericardial and cardiac masses in patients with established malignant neoplasms represent a diagnostic and therapeutic challenge. We present the case of a 66-year-old woman with history of myxoid liposarcoma of the left thigh who had an unexpected recurrence in the pericardium 12 years later.
View Article and Find Full Text PDFIntroduction: Understanding how a research sample compares to the population from which it is drawn can help inform future recruitment planning. We compared the Wisconsin Alzheimer's Disease Research Center (WADRC) participant sample to the Wisconsin state population (WI-pop) on key demographic, social exposome, and vascular risk measures.
Methods: The WADRC sample included 930 participants.
Open Forum Infect Dis
January 2025
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Background: We investigated hospitalized carbapenem-resistant Enterobacterales (CRE) and extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) cases with and without COVID-19, as identified through Emerging Infections Program surveillance in 10 sites from 2020 to 2022.
Methods: We defined a CRE case as the first isolation of , complex, , , , or resistant to any carbapenem. We defined an ESBL-E case as the first isolation of , , or resistant to any third-generation cephalosporin and nonresistant to all carbapenems tested.
Physiol Plant
January 2025
Laboratory of Plant Physiology, Universidad de Extremadura, Badajoz, Spain.
Plant sphingolipids are lipophilic membrane components essential for different cellular functions but they also act as signaling molecules in various aspects of plant development. However, the interaction between plant sphingolipids and abscission remains largely uncharacterized. Here, the possible role of sphingolipids in regulating fruit abscission was examined in the abscission zone (AZ) of olive fruit.
View Article and Find Full Text PDFPlant Foods Hum Nutr
January 2025
Departamento de Investigación y Posgrado en Alimentos, Facultad de Química, Universidad Autónoma de Querétaro, Querétaro, Qro., 76010, México.
Grape pomace (GP) is a by-product rich in phytochemicals, including extractable polyphenols (EPPs) and non-extractable polyphenols (NEPPs), which have distinct metabolic fates that may affect their biological activities. The benefits of GP have been reported in relation to obesity and its comorbidities, particularly when administered preventively focusing on EPPs. Therefore, the aim of this study was to investigate the effects of EPPs and NEPPs from GP as a treatment for obesity and its associated metabolic alterations.
View Article and Find Full Text PDFSmall
January 2025
Materials Physics and Applications Division, Los Alamos National Laboratory, Los Alamos, NM, 87545, USA.
The atomic dispersion of nickel in Ni-N-C catalysts is key for the selective generation of carbon monoxide through the electrochemical carbon dioxide reduction reaction (CORR). Herein, the study reports a highly selective, atomically dispersed Ni-N-C catalyst with reduced Ni loading compared to previous reports. Extensive materials characterization fails to detect Ni crystalline phases, reveals the highest concentration of atomically dispersed Ni metal, and confirms the presence of the proposed Ni-N active site at this reduced loading.
View Article and Find Full Text PDFAppl Biochem Biotechnol
January 2025
Unidad de Biotecnología Industrial, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco A.C, 45019, Zapopan, Jal, Mexico.
Lipases from the basidiomycete fungus Ustilago maydis are promising but underexplored biocatalysts due to their high homology with Candida antarctica lipases. This study provides a comprehensive characterization of a recombinant CALB-like lipase from U. maydis, expressed in Pichia pastoris (rUMLB), and compares its properties with those of the well-studied recombinant lipase B from C.
View Article and Find Full Text PDFSurg Endosc
January 2025
Department of Surgery, University of New Mexico Health Sciences Center, MSC10 5610, Albuquerque, NM, USA.
Background: Telemedicine has the potential to increase healthcare access while decreasing the environmental impact associated with providing care. We piloted total perioperative telemedicine (TPT) visits for evaluating patients with symptomatic cholelithiasis. We aimed to evaluate the feasibility and environmental impact of TPT by comparing the perioperative and environmental outcomes of patients participating in TPT to those undergoing traditional in-person preoperative evaluations.
View Article and Find Full Text PDFJ Comput Chem
January 2025
Departamento de Fisicoquímica, Facultad de Química, Universidad Nacional Autónoma de México, Coyoacán, CDMX, Mexico.
The G protein-coupled receptor (GPCR) pharmacology accounts for a significant field in research, clinical studies, and therapeutics. Computer-aided drug discovery is an evolving suite of techniques and methodologies that facilitate accelerated progress in drug discovery and repositioning. However, the structure-activity relationships of molecules targeting GPCRs are highly challenging in many cases since slight structural modifications can lead to drastic changes in biological functionality.
View Article and Find Full Text PDFJ Dent Educ
January 2025
Kansas City University College of Dental Medicine, Joplin, Missouri, USA.
The 2024 ADEA Annual Session Chair of the Board Symposium titled, Global Collaborations to Change the Paradigm in Oral Health Education and Care, aimed to highlight innovative global education models in oral health. The symposium sought to identify and explore opportunities for collaboration with international partners to ensure sustainable healthcare education to improve the oral health workforce. Additionally, it focused on discovering and adapting innovative solutions and best practices to enhance access to oral health services worldwide.
View Article and Find Full Text PDFEcol Appl
January 2025
Department of Forest and Wildlife Ecology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Fire shapes biodiversity in many forested ecosystems, but historical management practices and anthropogenic climate change have led to larger, more severe fires that threaten many animal species where such disturbances do not occur naturally. As predators, owls can play important ecological roles in biological communities, but how changing fire regimes affect individual species and species assemblages is largely unknown. Here, we examined the impact of fire severity, history, and configuration over the past 35 years on an assemblage of six forest owl species in the Sierra Nevada, California, using ecosystem-scale passive acoustic monitoring.
View Article and Find Full Text PDFNat Immunol
January 2025
Pathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Geroscience
January 2025
Department of Neuropathology, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México (UNAM), 04510, Mexico City, Mexico.
D-β-hydroxybutyrate, BHB, has been previously proposed as an anti-senescent agent in vitro and in vivo in several tissues including vascular smooth muscle. Moreover, BHB derivatives as ketone esters alleviate heart failure. Here, we provide evidence of the potential therapeutic effect of BHB on Hutchinson-Gilford progeria syndrome (HGPS), a rare condition characterized by premature aging and heart failure, caused by the presence of progerin, the aberrant protein derived from LMNA/C gene c.
View Article and Find Full Text PDFPort J Card Thorac Vasc Surg
October 2024
Plastic and Recontructive Surgery Department, Centro Médico Nacional Siglo XXI - Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Vascular malformations (VMs) are dysplastic abnormalities of vascular channels, differing from vascular tumors by their slow growth. Arteriovenous malformations (AVMs) arise between weeks 4-10 of intrauterine life, with a prevalence of 1 in 100,000 among Caucasians. Common in the head, neck, and hands, AVMs may be asymptomatic or cause symptoms like pain, deformity, and disability.
View Article and Find Full Text PDFNeotrop Entomol
January 2025
State Key Lab for Biology of Plant Diseases and Insect Pests, Key Lab of Invasive Alien Species Control of Ministry of Agriculture and Rural Affairs, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.
Climate warming is affecting the ranges and population dynamics of invasive species, including insects, which have become a global problem, causing biodiversity declines and agricultural economic losses. Anthonomus eugenii as an important invasive pest on pepper is now mainly located in the USA and Mexico. However, the global potential geographic distribution (PGD) of A.
View Article and Find Full Text PDFCerebellum
January 2025
Genetics Department, National Institute of Neurology and Neurosurgery Manuel Velasco Suárez, Insurgentes Sur 3877. La Fama, Tlalpan, 14269, Mexico City, Mexico.
Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant (AD) neurodegenerative disorder prevalent in the Americas, particularly in Mexico. Clinical manifestations include progressive ataxia and epilepsy. However, it can exhibit wide phenotypic variability and even reduced penetrance.
View Article and Find Full Text PDFAppl Microbiol Biotechnol
January 2025
Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Av. Instituto Politécnico Nacional No, 2508, C.P. 07360, Mexico City, Mexico.
One of the most significant bacteriophage technologies is phage display, in which heterologous peptides are exhibited on the virion surface. This work describes the display of λ decorative protein D linked to the E protein domain III of Zika virus (D-ZE), to the GFP protein (D-GFP), or to different domain III epitopes of the E protein (D-TD), exhibited on the surface of an in vitro evolved lambda phage (λ). This phage harbors a gene D deletion and was subjected to directed evolution using Escherichia coli W3110/pD-ZE as background.
View Article and Find Full Text PDFG3 (Bethesda)
January 2025
Xiphophorus Genetic Stock Center, Texas State University, San Marcos, TX 78666, USA.
Occurrence of degenerative interactions is thought to serve as a mechanism underlying hybrid unfitness in most animal systems. However, the molecular mechanisms underpinning the genetic interaction and how they contribute to overall hybrid incompatibilities are limited to only a handful of examples. A vertebrate model organism, Xiphophorus, is used to study hybrid dysfunction, and it has been shown from this model that diseases, such as melanoma, can occur in certain interspecies hybrids.
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