1,268 results match your criteria: "Metropolitan Komagome Hospital[Affiliation]"
J Clin Oncol
January 2025
Breast Surgery, Kyoto University Graduate School of Medicine, Shogoin Sakyo-ku, Kyoto, Japan.
In the primary analysis of the open-label phase III PRECIOUS study, pertuzumab retreatment combined with trastuzumab plus chemotherapy of physician's choice (PTC) significantly improved investigator-assessed progression-free survival (PFS) compared with trastuzumab plus physician's choice chemotherapy (TC) in patients with human epidermal growth factor receptor 2 (HER2)-positive locally advanced/metastatic breast cancer (LA/mBC). Here, we report final overall survival (OS) at the median follow-up of 25.8 months.
View Article and Find Full Text PDFJBJS Case Connect
October 2024
Department of Orthopaedic Surgery, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Case: An 18-year-old woman presented with shoulder pain that had persisted for a year. The magnetic resonance imaging showed a solitary lesion in the subacromial bursa (SAB). Arthroscopy revealed an ovoid mass connected to the bursal wall with thin synovial tissue that was excised en bloc arthroscopically.
View Article and Find Full Text PDFBr J Haematol
January 2025
Department of Nursing, Tohoku Fukushi University, Sendai, Japan.
Zandelisib, a selective, potent PI3Kδ inhibitor, demonstrated favourable outcomes in patients with relapsed or refractory follicular lymphoma in a global phase II study. This phase II study evaluated the efficacy and safety of zandelisib for relapsed or refractory follicular lymphoma or marginal zone lymphoma. Sixty-one patients received zandelisib orally at 60 mg daily continuously in the first two 28-day cycles, followed by intermittent dosing on Days 1-7 following each cycle until progressive disease or unacceptable toxicity.
View Article and Find Full Text PDFAnn Surg Oncol
February 2025
Division of Esophageal Surgery, National Cancer Center Hospital East, Chiba, Japan.
Ann Surg Oncol
February 2025
Division of Esophageal Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
Asia Pac J Ophthalmol (Phila)
December 2024
Department of Ophthalmology and Visual Science, Institute of Science Tokyo, Tokyo, Japan.
Purpose: To observe the detailed structures of the inner and outer sclera at various stages of myopic maculopathy using polarization-sensitive optical coherence tomography (PS-OCT).
Methods: A PS-OCT system was developed for imaging the posterior eye using a swept laser. Data from highly myopic patients who underwent PS-OCT examination between May and June 2019 were used to generate birefringence images (showing scleral fiber density), optic axis images (visualizing the orientation of scleral fibers), and streamline images (providing 3D reconstructions to visualize scleral fiber stream).
Ann Surg Oncol
February 2025
Division of Esophageal Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
J Neuroimaging
November 2024
Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan.
Background And Purpose: Slowly expanding lesions (SELs) have been proposed as novel MRI markers of chronic active lesions in multiple sclerosis (MS). However, the mechanism through which SELs affect brain volume loss in patients with MS remains unknown. Additionally, the prevalence and significance of SELs in Asian patients with MS remain unclear.
View Article and Find Full Text PDFOnco Targets Ther
September 2024
Department of Respiratory Medicine, Tokyo Metropolitan Komagome Hospital, Bunkyo-ku, Japan.
Scand J Gastroenterol
October 2024
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Omori Medical Center, Tokyo, Japan.
Objectives: While autoimmune pancreatitis (AIP) responds well to steroid therapy, the high relapse rate in type 1 AIP remains a critical problem. The present study examined predictors of relapse of type 1 AIP following steroid therapy.
Materials And Methods: Nine factors potentially predictive of relapse were analyzed in 81 AIP patients receiving steroid therapy with follow-up ≥ 12 months.
Esophagus
January 2025
Department of Otolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Neurology
October 2024
From the Department of Neurology (H.Y., T.M., Y.M.), Tokyo Metropolitan Komagome Hospital; Department of Neurology and Neurological Science (H.Y.), Tokyo Medical and Dental University; Department of Radiology (K.M.), Tokyo Metropolitan Komagome Hospital; and Department of Virology (K.N.), National Institute of Infectious Diseases, Japan.
J Neuroimmunol
September 2024
Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan.
Progression independent of relapse activity (PIRA) is prevalent among Caucasian patients with relapsing and remitting multiple sclerosis (RRMS). However, there is limited knowledge regarding the characteristics of PIRA in Asian patients with RRMS. Therefore, we retrospectively analyzed the clinical and radiological progression of 95 Japanese patients with RRMS during a 2-year observation period.
View Article and Find Full Text PDFHaematologica
November 2024
Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo.
Primary vitreoretinal lymphoma (PVRL) is a rare malignant lymphoma subtype with an unfavorable prognosis due to frequent central nervous system (CNS) progression. Thus, identifying factors associated with CNS progression is essential for improving the prognosis of PVRL patients. Accordingly, we conducted a comprehensive genetic analysis using archived vitreous humor samples of 36 PVRL patients diagnosed and treated at our institution and retrospectively examined the relationship between genetic alterations and CNS progression.
View Article and Find Full Text PDFBone Marrow Transplant
August 2024
Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.
Disease recurrence remains the principal cause of treatment failure after allogeneic hematopoietic stem cell transplantation. Post-transplant maintenance therapy with azacitidine (AZA) is promising to prevent relapse but the outcomes are unsatisfactory in patients at high risk of recurrence. Herein, we evaluated the outcome in patients who received AZA and gemtuzumab ozogamicin (GO), anti-CD33 antibody-calicheamicin conjugate, as post-transplant maintenance therapy.
View Article and Find Full Text PDFBreast Cancer Res Treat
August 2024
Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
Purpose: The randomized phase 2 Neo-peaks study examined usefulness of neoadjuvant trastuzumab emtansine + pertuzumab (T-DM1 + P) following docetaxel + carboplatin + trastuzumab + pertuzumab (TCbHP) as compared with the standard TCbHP regimen. We previously reported that pCR rate after neoadjuvant therapy tended to be higher with TCbHP followed by T-DM1 + P. We conducted an exploratory analysis of prognosis 5 years after surgery.
View Article and Find Full Text PDFInt J Clin Oncol
May 2024
Department of Pediatrics, Toho University, Tokyo, Japan.
Breast Cancer
May 2024
Department of Breast and Endocrine Surgery, Kumamoto University Hospital, Kumamoto, Japan.
The Japanese Breast Cancer Society Clinical Practice Guidelines are published as timely guidance on clinical issues in breast cancer treatment in Japan. In the recent edition of these guidelines, we addressed a new clinical question 34 (CQ 34, systemic treatment part) "Is trastuzumab deruxtecan recommended for patients with unresectable or metastatic HER2-low breast cancer?" and a new future research question 7 (FRQ 7, pathological diagnosis part) "How is HER2-low breast cancer diagnosed for the indication of trastuzumab deruxtecan?". These questions address use of trastuzumab deruxtecan in patients with unresectable or metastatic HER2-low breast cancer who have previously received chemotherapy for metastatic disease.
View Article and Find Full Text PDFIn Vivo
March 2024
Department of Esophageal Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
Background/aim: Rechallenge with immune checkpoint inhibitors following immune-related adverse events (irAEs) during the treatment of certain cancers reportedly has good efficacy. However, the subsequent clinical course of esophageal cancer remains unclear. This study investigated the nature of irAEs and the efficacy of a nivolumab rechallenge for patients with esophageal cancer.
View Article and Find Full Text PDFWe herein report a case of interstitial lung changes in a patient with prolonged coronavirus disease 2019 (COVID-19) with follicular lymphoma receiving rituximab and bendamustine who recovered after treatment with a combination therapy consisting of corticosteroids and immunosuppressive agents. There is currently no treatment strategy for prolonged pneumonitis following COVID-19, which can be life-threatening for immunocompromised patients. Thus, further investigation is warranted.
View Article and Find Full Text PDFClin Lung Cancer
June 2024
Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Diagnostics (Basel)
January 2024
Department of Virology II, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS) caused by reactivation of dormant JC polyomavirus (JCPyV). PML was mainly observed in immunocompromised individuals, such as HIV-positive patients, autoimmune disease patients, and cancer patients. Given that the presence of anti-JCPyV antibodies in serum is a risk indicator for PML development, it is essential to monitor anti-JCPyV antibody levels.
View Article and Find Full Text PDFGan To Kagaku Ryoho
December 2023
Dept. of Esophageal Surgery, Tokyo Metropolitan Komagome Hospital.
A 51-year-old male presented with swelling on the left side of his neck. A diagnosis of thoracic esophageal cancer(Lt type 5a, squamous cell carcinoma, T3N4[16LN]M1[skin, bone, retroperitoneum, lung], cStage Ⅳb)was made, and treatment with a combination of 5-FU plus CDDP and pembrolizumab was initiated. After the 1st round of chemotherapy, there was an increase in metastases in the left cervical lymph node and skin, along with the development of back pain because of an L3 lumbar spine metastasis.
View Article and Find Full Text PDFGan To Kagaku Ryoho
December 2023
Dept. of Hepato-Biliary-Pancreatic Surgery, Tokyo Metropolitan Komagome Hospital.
As medical insurance coverage for robotic surgery has been expanded in the field of gastrointestinal surgery in Japan, the number of cases undergoing robotic surgery for hepato-biliary-pancreatic disease has been increasing. Therefore, cases with malignant tumors and metastatic lesions tend to undergo robotic operation for both primary tumors and metastases. Herein, we report a case of neuroendocrine tumor(NET)in the pancreatic tail with simultaneous single liver metastasis, which was treated with two-stage robotic-assisted surgery.
View Article and Find Full Text PDFBreast Cancer
March 2024
Department of Medical Oncology, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
The Japanese Breast Cancer Society initiated the breast cancer registry in 1975, which transitioned to the National Clinical Database-Breast Cancer Registry in 2012. This annual report presents data from 2020 and analyzes the ten-year mortality rates for those aged 65 and older. We analyzed data from 93,784 breast cancer (BC) cases registered in 2020 and assessed 10-year mortality rates for 36,279 elderly patients diagnosed between 2008 and 2012.
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