1 results match your criteria: "Metropolitan Independent University[Affiliation]"
Bcl-2 overexpression in hepatic stellate cell line CFSC-2G, induces a pro-fibrotic state.
J Gastroenterol Hepatol
July 2010
Health and Sciences Department, Biological and Health Sciences Division, Metropolitan Independent University, México, DF, México.
Background And Aim: Development of hepatic fibrosis is a complex process that involves oxidative stress (OS) and an altered balance between pro- and anti-apoptotic molecules. Since Bcl-2 overexpression preserves viability against OS, our objective was to address the effect of Bcl-2 overexpression in the hepatic stellate cells (HSC) cell-line CFSC-2G under acetaldehyde and H(2)O(2) challenge, and explore if it protects these cells against OS, induces replicative senescence and/or modify extracellular matrix (ECM) remodeling potential.
Methods: To induce Bcl-2 overexpression, HSC cell line CFSC-2G was transfected by lipofection technique.