4,491 results match your criteria: "Methemoglobinemia"

Etiologies of blue lips: A review.

Ann Dermatol Venereol

December 2024

Department of Dermatology, Charles Nicolle Hospital, Tunis, Tunisia; Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

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Methemoglobinemia is a rare but potentially life-threatening condition in which hemoglobin is oxidized, impairing the oxygen-carrying capacity. While congenital forms exist, acquired methemoglobinemia can occur in perioperative settings, especially following exposure to oxidizing agents such as dyes used in sentinel lymph node biopsy (SLNB). Patent Blue V, a synthetic aniline dye commonly used for SLNB, has been associated with rare but serious adverse effects, including methemoglobinemia.

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Methaemoglobinaemia is a rare factor that can lead to cyanosis. The predominant cause of acquired methaemoglobinaemia is commonly attributed to anaesthetic agents. This case series presents three instances of acquired methaemoglobinaemia resulting from acute gastroenteritis caused by formula feeds.

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Introduction: Nitric and hydrofluoric acids are commonly used in the commercial cleaning industry. We are unaware of reports of nitric acid inhalation forming methaemoglobin. Additionally, methaemoglobinaemia and treatment with methylthioninium chloride (methylene blue) may precipitate clinical uncertainty due to similar wavelengths of absorbance in pulse oximetry.

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Tumor lysis syndrome (TLS) is a critical oncologic emergency characterized by metabolic disturbances resulting from rapid cancer cell lysis. Rasburicase, a recombinant urate oxidase, is the primary treatment for hyperuricemia in TLS but poses a risk for methemoglobinemia in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. We present the case of a 59-year-old male with diffuse large B-cell lymphoma (DLBCL) who developed spontaneous TLS.

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Methemoglobinemia is a rare, yet life-threatening disorder that occurs due to an accumulation of methemoglobin in the blood. The clinical presentation often includes dyspnea, cyanosis, and hypoxemia that shows little improvement with the administration of supplemental oxygen. The US Food and Drug Administration (FDA) warns against the administration of benzocaine to those younger than 2 years of age and urges manufacturers to add a statement regarding the possible development of methemoglobinemia to the packaging of any products containing this ingredient.

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A 10-year retrospective review of exposures to volatile nitrites reported to the Victorian Poisons Information Centre.

Clin Toxicol (Phila)

November 2024

Pharmacy Department, Austin Health, Heidelberg, Australia.

Article Synopsis
  • Volatile nitrites, like amyl nitrite, are recreationally used for enhanced sexual experiences but can lead to serious health issues, prompting a study from the Victorian Poisons Information Centre covering a decade.
  • Over ten years, there was a significant rise in reported cases, with 132 calls about 122 exposures, often linked to ingestion and inhalation; common symptoms included dizziness, irritation, and nausea, while more serious effects occurred in a minority of cases.
  • The study highlights the increasing use of volatile nitrites in Australia, underscoring the need for improved community education and harm reduction strategies among users and healthcare providers.
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Life-Threatening Methaemoglobinaemia Secondary to Cetrimide.

Eur J Case Rep Intern Med

September 2024

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mount Lebanon Hospital Balamand University Medical Center, Beirut, Lebanon.

Article Synopsis
  • * The condition is characterized by oxidized hemoglobin (ferric state), leading to symptoms like low blood oxygen levels, hypoxia, and distinct chocolate-colored blood.
  • * A case study highlights how cetrimide, used in abdominal surgeries for hydatid cysts, can trigger severe methaemoglobinaemia, which often goes undiagnosed but has a high risk of mortality.
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  • - Methaemoglobinaemia and Heinz-body haemolytic anaemia are serious but treatable effects of aniline poisoning, with management focusing on removing the poison and addressing methaemoglobinaemia.
  • - Treatment for methaemoglobinaemia depends on the blood methaemoglobin levels; levels below 30% need only supplemental oxygen, while levels above require intravenous methylene blue, with close monitoring for complications.
  • - In a successful case report, six patients were treated with methylene blue for methaemoglobinaemia after aniline poisoning, and two of those patients, who experienced further complications, also needed exchange transfusions.
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Introduction: Methemoglobinemia is a potentially life-threatening condition characterized by the reduced oxygen-carrying capacity of hemoglobin. With the increasing popularity of natural and herbal biopesticides, there is a growing risk of exposure to substances that can induce this dyshemoglobinemia. This case report highlights the importance of recognizing and promptly treating methemoglobinemia in the context of biopesticide exposure, a concern relevant to various healthcare professionals.

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Maternal NO exposure and fetal growth restriction: Hypoxia transmission and lncRNAs-proinflammation-mediated abnormal hematopoiesis.

Proc Natl Acad Sci U S A

October 2024

Department of Environment Science, College of Environment and Resource, Research Center of Environment and Health, Shanxi Key Laboratory of Coal-based Emerging Pollutant Identification and Risk Control, Shanxi University, Taiyuan, Shanxi 030006, People's Republic of China.

Article Synopsis
  • Epidemiological studies indicate that air pollution, specifically nitrogen dioxide (NO), is linked to fetal growth restriction (FGR), particularly when exposure occurs during the second trimester.
  • A retrospective analysis of nearly 29,000 newborns showed a positive correlation between maternal NO exposure and the risk of having small-for-gestational-age babies, with a specific odds ratio calculated.
  • Animal studies further confirmed that maternal NO inhalation affects embryonic development and the hematopoietic system, with findings suggesting that this exposure leads to placental hypoxia, thereby activating certain biological pathways that contribute to FGR.
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  • The study focuses on the effectiveness of 8-aminoquinolines (primaquine and tafenoquine) in curing Plasmodium vivax malaria by targeting hypnozoites, with a specific look at the role of methaemoglobin levels as a potential indicator for preventing malaria recurrence.
  • The researchers conducted a systematic review of clinical studies from 2000 to 2022 and examined data from 1,747 patients treated with primaquine to analyze the relationship between methaemoglobin concentration and the time to malaria recurrence.
  • Their findings suggest that higher methaemoglobin levels may correlate with a lower risk of P. vivax recurrence, indicating the potential use of methaemoglobin as
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Article Synopsis
  • * A case involving a 61-year-old woman who experienced respiratory failure after surgery highlighted how benzocaine spray for throat pain may have triggered her methemoglobinemia, worsening her pneumonia symptoms.
  • * The patient was successfully treated with high doses of vitamin C and methylene blue, prompting this report to stress the importance of quick diagnosis and treatment for better recovery outcomes.
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  • Methemoglobinemia is a rare condition in children, with a prevalence of only 0.0015% and a 30-day mortality rate of 6.1%.
  • The study reviewed data from 98 children and found that those with higher methemoglobin levels (over 20%) received methylene blue treatment more frequently.
  • There is a low rate of G6PD testing despite the risk it poses when administering methylene blue, indicating a need for improved clinician education regarding treatment and assessment of this disease.
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  • Hemoglobin (Hb) Chile is a rare variant caused by a specific point mutation in the Hb β locus gene, leading to an amino acid change and inherited in an autosomal dominant way.
  • A case study presented a 17-year-old male with symptoms like pale skin and cyanosis, who was found to have low oxygen saturation and elevated methemoglobin levels, indicating a health issue.
  • Genetic testing revealed a new mutation related to Hb Chile that wasn't present in his parents, emphasizing the importance of checking for Hb gene mutations in patients with unexplained chronic methemoglobinemia, regardless of their family history.
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  • * A 43-year-old man with a history of diabetes and hypertension showed symptoms of methemoglobinemia, including bluish discoloration of his fingers, after using the inhalant "Rush," leading to low oxygen saturation and elevated methemoglobin levels.
  • * Treatment with methylene blue successfully resolved the patient’s symptoms, but resulted in green urine, highlighting the importance of thorough history taking and awareness of treatment side effects in managing inhalant-related cases.
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Article Synopsis
  • - Discrepancies between pulse oximetry and arterial oxygen saturation can complicate clinical assessments, often caused by factors like poor blood flow, skin color, movement, or specific blood conditions.
  • - Unstable hemoglobin variants, such as hemoglobin Köln, are rare genetic mutations that can disrupt the normal structure and function of hemoglobin, affecting its ability to bind oxygen.
  • - This case study highlights a 44-year-old Arabic woman diagnosed with hemoglobin Köln after extensive investigations revealed significant differences between her pulse oximetry readings and arterial oxygen saturation.
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  • Naphthalene, commonly found in mothballs, is rarely associated with poisoning, but a case of ingestion leading to significant symptoms is described.
  • A 20-year-old male with a seizure disorder ingested multiple mothballs and experienced severe abdominal pain, vomiting, blood in urine, hemolysis, and methemoglobinemia.
  • After various treatments, including plasmapheresis and hemodialysis, the patient improved and was discharged after 15 days, receiving psychiatric care during recovery.
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