7,297 results match your criteria: "Metabolic Alkalosis"
Furosemide with adjunctive acetazolamide vs furosemide only in critically ill patients: A pilot two-center randomized controlled trial.
J Crit Care
December 2024
Department of Intensive Care, Austin Hospital, Melbourne, Australia; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Australia; Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Purpose: Furosemide is the most commonly used diuretic in intensive care units (ICU). We aimed to evaluate the physiological effects of adjunctive acetazolamide with furosemide on diuresis and the prevention of potential furosemide-induced metabolic alkalosis.
Materials And Methods: We performed a two-center, pilot, open-label, randomized trial.
Impact of adolescents' binge drinking on blood chemistry.
Eur J Pediatr
December 2024
Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Della Commenda 9, 20122, Milan, Italy.
Article Synopsis
- - The study examined the effects of binge drinking on adolescent blood chemistry, focusing on glucose, sodium, calcium, potassium, and acid-base balance, by analyzing medical records from 173 teenagers treated at a Milan hospital between 2013 and 2023.
- - Results showed that while glucose, sodium, and calcium levels were generally stable, there were significant cases of hypokalemia and an overwhelming presence of acute respiratory acidosis among binge drinkers.
- - The findings indicate that binge drinking in adolescents leads to notable disturbances in acid-base balance and potassium levels, but has little impact on glucose, sodium, and calcium levels.
Reninoma: an unusual cause of growth failure.
J Pediatr Endocrinol Metab
December 2024
Department of Endocrinology and Diabetes, Max Super Speciality Hospital, Saket, Delhi, India.
Article Synopsis
The safety and efficacy of regional citrate anticoagulation for multiple consecutive therapeutic plasma exchanges with fresh frozen plasma as a replacement solution.
Int Urol Nephrol
December 2024
The Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, No. 127 Changle West Road, Xi'an, 710032, Shaanxi, China.
Background: Therapeutic plasma exchange (TPE) is an important blood purification technology and most patients require multiple consecutive TPEs. Regional citrate anticoagulation (RCA) could be used for membrane therapeutic plasma exchange (mTPE). However, there is no research on the metabolic complications of the RCA for patients receiving multiple consecutive mTPEs with fresh frozen plasma (FFP) as a replacement solution.
View Article and Find Full Text PDFManaging Amitraz Poisoning: Epidemiological Data and Clinical Insights From a Tertiary Care Hospital in Southern India.
Cureus
November 2024
Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, IND.
Article Synopsis
IMPACT OF HYPOKALEMIA ON HEPATIC ENCEPHALOPATHY AND ITS EFFECT ON DURATION OF STAY IN HOSPITAL.
J Ayub Med Coll Abbottabad
December 2024
PAF Hospital, Islamabad-Pakistan.
Article Synopsis
- Hypokalemia is a key factor in causing hepatic encephalopathy, leading to elevated ammonia levels that can affect the brain.
- A study at PAF Hospital, Islamabad, analyzed the medical records of 179 patients to explore the relationship between hypokalemia and hospital stay duration, using various statistical methods.
- Results indicated that patients with hypokalemia had a significantly longer hospital stay compared to those without it, with an average age of 36.76 years among participants.
Chronic pyloric obstruction caused by Flammulina mushroom: A rare case report.
Medicine (Baltimore)
November 2024
Department of Gastroenterology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Article Synopsis
- A man in his early 30s experienced chronic pyloric obstruction for 4 years, presenting with recurrent vomiting, ultimately linked to a blockage caused by a Flammulina mushroom.
- Diagnostic imaging and lab tests indicated gastric issues, leading to an endoscopic procedure where the foreign object was identified and removed.
- post-removal, the patient experienced complete resolution of symptoms, highlighting the need for thorough diagnostics in similar cases where obstructions may not follow typical patterns.
Exploring the Spectrum of Comorbidities Associated with Primary Aldosteronism: Insights from a Large Real-World Case-Control Study.
Biomedicines
October 2024
Epidemiology, IQVIA, 60549 Frankfurt, Germany.
Article Synopsis
Bartter Syndrome With Recurrent Hypokalemic Periodic Paralysis: A Case Report.
Cureus
October 2024
Medicine, All India Institute of Medical Sciences, Raipur, Raipur, IND.
Hypokalemia is known to manifest as neurological weakness and cardiac rhythm disturbances. Severe hypokalemia can be life-threatening and needs prompt recognition and management. However, the workup for hypokalemia is equally essential to prevent future recurrences and complications.
View Article and Find Full Text PDFMetabolic Alkalosis.
Adv Kidney Dis Health
November 2024
MedStar Georgetown University Hospital, Division of Nephrology, Washington, DC.
Metabolic alkalosis is one of the four cardinal acid-base disorders and perhaps the least well understood by students. Taking a mechanistic approach to etiologies and management can be very helpful in such cases. Particularly, one should focus on the factors that generate the alkalosis (source of fluid loss and composition, less commonly alkali administration) and the factors (extracellular fluid volume status, hormonal systems) that maintain the abnormality.
View Article and Find Full Text PDFGitelman syndrome patient managed with amiloride during pregnancy and lactation.
BMC Nephrol
November 2024
Nephrology Division, Department of Internal Medicine, University of Utah Health, Salt Lake City, USA.
Article Synopsis
- Gitelman Syndrome (GS) is a rare genetic disorder that leads to low potassium and magnesium levels, alongside other metabolic issues, and presents unique challenges in managing these conditions during pregnancy.
- A case study of a 20-year-old woman with GS highlights the use of amiloride, a medication typically used for GS, to successfully manage her persistent low potassium levels during pregnancy and lactation.
- The treatment with amiloride effectively controlled her symptoms without causing any harmful effects on her newborn, suggesting potential safety for the mother and child under careful management.
The Effect of the Acid-Base Imbalance on the Shape and Structure of Red Blood Cells.
Cells
November 2024
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V.A. Negovsky Research Institute of General Reanimatology, 107031 Moscow, Russia.
Article Synopsis
Pyloric index, a new parameter: predicting perioperative prognosis in neonates with hypertrophic pyloric stenosis.
Scand J Gastroenterol
December 2024
Department of Neonatology, Dr. Sami Ulus Maternity and Child Research and Training Hospital, Altındag, Ankara, Turkey.
Article Synopsis
Licorice Toxicity Presenting As Refractory Hypokalemia and Hypertension in an Elderly Patient.
Cureus
November 2024
Acute Medicine, Lancashire Teaching Hospitals, Lancashire, GBR.
Article Synopsis
NHCl-induced metabolic acidosis increases the abundance of HCO transporters in the choroid plexus of mice.
Front Physiol
October 2024
Department of Biomedicine, Faculty of Health, Aarhus University, Aarhus, Denmark.
Article Synopsis
Finerenone as a Novel Treatment for Gitelman Syndrome: A Case Study of a 35-Year-Old Male with Adrenal Mass and Hypokalemia.
Am J Case Rep
November 2024
Department of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Article Synopsis
- - Gitelman syndrome (GS) is a rare genetic disorder leading to electrolyte imbalances, notably low potassium levels, due to a mutation in the SLC12A3 gene, affecting kidney function.
- - A 35-year-old man with GS and severe hypokalemia was treated with finerenone, a new medication that helps increase potassium levels without the adverse effects commonly seen with other treatments like spironolactone.
- - This case is significant as it represents the first reported use of finerenone for Gitelman syndrome, providing an alternative treatment option for patients unable to tolerate traditional therapies.
Persistent renal dysfunction post-chemotherapy: a diagnostic conundrum in pediatric cancer survivorship - a case report.
BMC Pediatr
October 2024
Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, CA, US.
Article Synopsis
Optimizing Continuous Renal Replacement Therapy with Regional Citrate Anticoagulation: Insights from the ORCA Trial-A Retrospective Study on 10 Years of Practice.
Life (Basel)
October 2024
The Departments of Critical Care Medicine, Antwerp University Hospital, 2650 Edegem, Belgium.
(1) Background: Citrate is preferred in continuous renal replacement therapy (CRRT) for critically ill patients because it prolongs filter life and reduces bleeding risks compared to unfractionated heparin (UFH). However, regional citrate anticoagulation (RCA) can lead to acid-base disturbances, citrate accumulation, and overload. This study compares the safety and efficacy of citrate-based CRRT with UFH and no anticoagulation (NA) in acute kidney injury (AKI) patients.
View Article and Find Full Text PDFMetabolic Alkalemia in Hypercalciuria Stone Formers: Does It Matter?
Kidney Blood Press Res
December 2024
Laboratório de Pesquisa Básica da Unidade de Doenças Renais (LIM 12), Nefrologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Article Synopsis
- - The study examines metabolic alkalemia in outpatients with hypercalciuric nephrolithiasis, noting that these patients often use thiazides, which can cause chloride losses and potentially lead to metabolic imbalances.
- - Data collected from patient records showed that only 4.3% of patients had metabolic alkalemia, primarily those using thiazides, and the daily dosage was higher among those with the condition.
- - The findings highlight the prevalence of hypokalemia (37%) in patients with metabolic alkalemia and indicate lower levels of chloride, magnesium, and ionic calcium, suggesting the need for careful monitoring of these patients despite the low overall prevalence.
From Syncope to Pregnancy: A Case Report of Gestational Transient Thyrotoxicosis.
Cureus
September 2024
Department of Endocrinology, Diabetes, and Metabolism, Centro Hospitalar Universitário de Santo António, Unidade Local de Saúde de Santo António, Porto, PRT.
With a multifactorial etiology, syncope is a fairly common clinical presentation in emergency care. During pregnancy, it can result from hemodynamic and hormonal changes. One such rare cause is hyperthyroidism.
View Article and Find Full Text PDFMetabolic Alkalosis, Hypokalemia with Diarrhea due to Congenital Chloride Diarrhea.
Indian J Pediatr
December 2024
Department of Pediatric Hepatology and Gastroenterology, B J Wadia Hospital for Children, Mumbai, India.
Cushing's Storm: A Case of Paraneoplastic Cushing's Syndrome-Induced Seizures Treated With Continuous Etomidate Infusion.
Cureus
September 2024
Pulmonary and Critical Care Medicine, University of Florida College of Medicine, Jacksonville, USA.
Article Synopsis
- A 67-year-old woman showed signs of abdominal pain, nausea, vomiting, and weight loss, leading to a diagnosis of paraneoplastic Cushing's syndrome caused by small lung cancer.
- Tests indicated high cortisol levels and low potassium, while the patient also experienced severe seizures despite taking several anti-epileptic drugs.
- The treatment involved using continuous etomidate infusion to reduce cortisol levels, highlighting how understanding medication side effects can help in managing complex medical conditions.
Association between delta anion gap/delta bicarbonate and outcome of surgical patients admitted to intensive care unit.
BMC Anesthesiol
October 2024
Department of Anesthesiology, University of São Paulo, Sao Paulo, Brazil.
Article Synopsis
- High-risk surgical patients often face poor outcomes due to acid-base disorders, specifically metabolic acidosis, which can be assessed using the delta anion gap to bicarbonate ratio.* -
- This study aimed to evaluate the relationship between metabolic acidosis (MA) and complications in patients undergoing high-risk surgeries by categorizing them into three groups based on their delta AG/delta Bic values.* -
- Results showed that out of 621 patients, a significant portion had acidosis, and those in the subgroup with no mixed disorders had a notably higher risk of 30-day mortality and cardiovascular complications.*
Infantile Hypertrophic Pyloric Stenosis Without Metabolic Alkalosis: A Report of Two Cases.
Cureus
September 2024
Pediatrics, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pune, IND.
Article Synopsis
- Infantile hypertrophic pyloric stenosis (IHPS) is a condition in infants that causes the pylorus to thicken, resulting in gastric outlet obstruction and severe vomiting.
- This case series discusses two infants with IHPS who displayed metabolic acidosis, rather than the typical metabolic alkalosis usually seen in such cases.
- The presence of metabolic acidosis suggests there may be different underlying issues in these cases, indicating that diagnosing IHPS may require a more comprehensive approach.