30 results match your criteria: "Meshalkin National Medical Research Centre[Affiliation]"
Right ventricular outflow tract reconstruction using a polytetrafluoroethylene conduit in Ross patients.
Eur J Cardiothorac Surg
September 2018
Department of Heart Valve Surgery, E. Meshalkin National Medical Research Centre, Novosibirsk, Russian Federation.
Objectives: The type of conduit used for right ventricular outflow tract (RVOT) reconstruction during the Ross procedure remains problematic because of the limited availability of pulmonary allografts and the unsatisfactory long-term results associated with the use of xenografts. Polytetrafluoroethylene (PTFE) conduits have been proposed as an alternative. This study evaluated the results of RVOT reconstruction using a PTFE conduit during the Ross procedure.
View Article and Find Full Text PDFChronic Lung Disease and Mortality after Cardiac Surgery: A Prospective Cohort Study.
J Cardiothorac Vasc Anesth
October 2018
Department of Cardiac Surgery, Meshalkin National Medical Research Centre, Novosibirsk, Russia.
Objective: To investigate the 1-year survival in cardiac surgical patients with lung disease, including previously undiagnosed cases.
Design: Prospective cohort study.
Setting: Tertiary hospital.
Alternative dominance of the parental genomes in hybrid cells generated through the fusion of mouse embryonic stem cells with fibroblasts.
Sci Rep
December 2017
Institute of Cytology and Genetics, Novosibirsk, 630090, Russia.
For the first time, two types of hybrid cells with embryonic stem (ES) cell-like and fibroblast-like phenotypes were produced through the fusion of mouse ES cells with fibroblasts. Transcriptome analysis of 2,848 genes differentially expressed in the parental cells demonstrated that 34-43% of these genes are expressed in hybrid cells, consistent with their phenotypes; 25-29% of these genes display intermediate levels of expression, and 12-16% of these genes maintained expression at the parental cell level, inconsistent with the phenotype of the hybrid cell. Approximately 20% of the analyzed genes displayed unexpected expression patterns that differ from both parents.
View Article and Find Full Text PDFImpact of Xist RNA on chromatin modifications and transcriptional silencing maintenance at different stages of imprinted X chromosome inactivation in vole Microtus levis.
Chromosoma
March 2018
Federal Research Centre "Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences", Prospekt Lavrentyeva, 10, Novosibirsk, 630090, Russia.
Article Synopsis
- In voles (Microtus levis), preimplantation embryo and extraembryonic tissue cells experience a process called imprinted X chromosome inactivation (iXCI), which is initiated by the long non-coding RNA known as Xist.
- The study used vole trophoblast stem (TS) cells to explore the chromatin structure of the inactive X chromosome, noting the presence of certain proteins and histone modifications.
- Findings revealed that while Xist RNA didn't play a major role in maintaining the inactive state of the X chromosome, it was essential for recruiting an additional histone modification during the differentiation of these cells.
Heparan Sulfate Biosynthetic System Is Inhibited in Human Glioma Due to EXT1/2 and HS6ST1/2 Down-Regulation.
Int J Mol Sci
November 2017
Institute of Molecular Biology and Biophysics, Novosibirsk 630117, Russia.
Heparan sulfate (HS) is an important component of the extracellular matrix and cell surface, which plays a key role in cell-cell and cell-matrix interactions. Functional activity of HS directly depends on its structure, which determined by a complex system of HS biosynthetic enzymes. During malignant transformation, the system can undergo significant changes, but for glioma, HS biosynthesis has not been studied in detail.
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