Tetracaine downregulates matrix metalloproteinase activity and inhibits invasiveness of strongly metastatic MDA-MB-231 human breast cancer cells.

Tetracaine, a long-acting amino ester-type local anesthetic, prevents the initiation and propagation of action potentials by reversibly blocking voltage-gated sodium channels (VGSCs). These channels, which are highly expressed in several carcinomas (e.g.

Role of acetyl-CoA acetyltransferase 1 expression in the molecular mechanism of adenomyosis.

Objective: Adenomyosis is a benign uterine illness characterized by endometrial gland and stromal invasion into the myometrium. Acetyl-CoA acetyltransferase 1 () is an enzyme localized in mitochondria that is involved in ketogenesis and ketolysis processes by reversibly catalyzing the formation of acetoacetyl-CoA from two acetyl-CoA molecules. The current study investigated the expression of the molecule in tissue samples of patients diagnosed with adenomyosis and healthy endometrial tissues.

The Immediate Effect of Cumulative Transverse Strain via Exercise on the Achilles Tendon in Individuals with and Without Flat Feet.

Background: Flat feet change lower extremity alignment, and it may change the load distribution on Achilles tendon during exercise. The purpose of the present study was to investigate the immediate effect of cumulative transverse strain via resistive ankle plantarflexion exercise on the Achilles tendon in individuals with flat feet.

Methods: Fourteen individuals with flat feet and 14 age-matched individuals with normal foot posture were enrolled in the present study.

A comprehensive study of Helicobacter pylori infection: molecular analysis, antibacterial susceptibility, and histopathological examination.

Helicobacter pylori is a pathogen associated with gastroduodenal diseases. This study aimed; (i) to investigate H. pylori presence by invasive tests in adult dyspeptic patients, (ii) to determine antibiotic susceptibility and genotypic characteristics of the H.

Paroxetine's effect on the proinflammatory cytokine stimulation and intracellular signaling pathways in J774.2 cells.

Paroxetine is extensively utilized in the management of depressive and anxious conditions. Paroxetine works by increasing serotonin levels in nerve cells in the brain. However, limited information is available regarding the direct effects of paroxetine on macrophage cells.

A retrospective evaluation of pregnant adolescents presenting to an emergency department.

The purpose of this study was to evaluate demographic features, presenting complaints and outcomes of adolescent pregnancies admitted to the emergency department of a Turkish State hospital. The study sample included 1187 pregnant adolescents admitted to the emergency department of a state hospital. Data were collected with a form created by the researchers from the emergency department records and forensic records of the hospital.

Investigation of antiviral substances in Covid 19 by Molecular Docking: In Silico Study.

Aims: This paper aimed to investigate the antiviral drugs against Sars-Cov-2 main protease (MPro) using in silico methods.

Material And Method: A search was made for antiviral drugs in the PubChem database and antiviral drugs such as Bictegravir, Emtricitabine, Entecavir, Lamivudine, Tenofovir, Favipiravir, Hydroxychloroquine, Lopinavir, Oseltamavir, Remdevisir, Ribavirin, Ritonavir were included in our study. The protein structure of Sars-Cov-2 Mpro (PDB ID: 6LU7) was taken from the Protein Data Bank (www.

Cytotoxic effect of silica nanoparticles on human retinal pigment epithelial cells.

In recent years, the use of nanotechnology-based methods has become widespread in the treatment of ocular diseases. Silica nanoparticles (SiO NPs) are most common used NPs in medical field due to their physicochemical properties. SiO NPs can easily cross biological membranes and interact with basic biological structures, causing structural and functional changes in cells.

Effects of virtual reality and acupressure interventions on pain, anxiety, vital signs and comfort in catheter extraction processes for patients undergoing coronary angiography: A randomized controlled trial.

Background: Pain and anxiety management in patients undergoing medical and surgical procedures is an important competence area for nurses.

Aim: This study aimed to determine and compare the effects of virtual reality and acupressure interventions on pain, anxiety, vital signs and comfort levels in the process of femoral catheter extraction for patients undergoing coronary angiography.

Methods: The study was a single-blind, three-group, randomized controlled trial conducted in the cardiology clinics of a university hospital in 2021.

Molecular Detection of Tacheng Tick Virus-1 (TcTV-1) and Jingmen Tick Virus in Ticks Collected from Wildlife and Livestock in Turkey: First Indication of TcTV-1 Beyond China.

Jingmen tick virus (JMTV) and Tacheng tick virus-1 (TcTV-1) are emerging tick-borne viruses that have been recently confirmed to be etiological agents of human disease in China. However, the ecology of JMTV and TcTV-1, especially their association with ticks in wildlife and livestock, remains largely unknown in Turkey. Eight hundred thirty-two tick specimens in 117 pools were collected in Turkey between 2020 and 2022 from wildlife ( and  = 10, 1.

Effect of bromelain on periodontal destruction and alveolar bone in rats with experimental periodontitis.

Purpose: Several substances that have anti-inflammatory, antiproteinase, and anti-infective properties have been evaluated as modulators of the inflammatory response in periodontal disease. However, evidence for the anti-inflammatory and antioxidative activities of bromelain is limited. This study evaluated the impact of systemically administered bromelain on the progression of experimental periodontitis.

A New Clinical Tool for Scoliosis Risk Analysis: Scoliosis Tele-Screening Test.

Study Design: Methodological, observational clinical study.

Purpose: This study aimed to develop a virtual screening test to detect scoliosis risk initially by parents without the need for medical visit during the coronavirus disease 2019 pandemic.

Overview Of Literature: The scoliosis screening program has been implemented to early detect scoliosis.

Effective deep learning classification for kidney stone using axial computed tomography (CT) images.

Introduction: Stone formation in the kidneys is a common disease, and the high rate of recurrence and morbidity of the disease worries all patients with kidney stones. There are many imaging options for diagnosing and managing kidney stone disease, and CT imaging is the preferred method.

Objectives: Radiologists need to manually analyse large numbers of CT slices to diagnose kidney stones, and this process is laborious and time-consuming.

Correlation of plasma metabolites and comorbid illnesses with poor sleep quality in patients with coronary heart disease.

Purpose: This study aimed to examine the relationship between plasma metabolites (biochemical parameters) and comorbid illnesses with sleep quality in individuals with coronary heart disease (CHD).

Methods: This descriptive cross-sectional study was conducted between 2020 and 2021 at a university hospital. Hospitalized patients with a diagnosis of CHD were analyzed.

Escitalopram's inflammatory effect on the mammalian macrophages and its intracellular mechanism of action.

The majority of patients with depression are treated with antidepressant drugs that are in the serotonin reuptake inhibitor (SSRI) group. Different studies have been conducted on the effect of treatment with antidepressants on the level of pro-inflammatory cytokines. There have been studies on the effects of escitalopram, an SSRI group antidepressant, on the pro-inflammatory cytokine levels both in vivo and in vitro.

Enhanced Bioactivity of Rosemary, Sage, Lavender, and Chamomile Essential Oils by Fractionation, Combination, and Emulsification.

This study aimed to increase the bioactivity of essential oils by fractionation, combination, and emulsification. In this regard, pharmaceutical quality L. (rosemary), L.

Association between executive and physical functions in people with Parkinson's disease.

Purpose: People with Parkinson's disease (PD) can develop cognitive and physical impairments. There is limited evidence on the association between executive function and physical function in people with PD.

Objective: We aimed to investigate the association between the executive and physical functions in people with Parkinson's disease (PD) by comparing healthy controls.

The effect of using illustrated materials for communication on the anxiety and comfort of cardiac surgery patients receiving mechanical ventilator support: A randomized controlled trial.

Background: Using illustrated communication materials with patients receiving mechanical ventilation support increases patient satisfaction and reduces communication difficulties. However, there are no randomized controlled clinical studies showing the effect of the use of these materials on patient care outcomes.

Objective: To determine the effect of using illustrated communication materials on the anxiety and comfort levels of patients receiving mechanical ventilation support.

Socially assistive robots in health and social care: Acceptance and cultural factors. Results from an exploratory international online survey.

Aim: This study explored the views of an international sample of registered nurses and midwives working in health and social care concerning socially assistive robots (SARs), and the relationship between dimensions of culture and rejection of the idea that SARs had benefits in these settings.

Methods: An online survey was used to obtain rankings of (among other topics) the extent to which SARs have benefits for health and social care. It also asked for free text responses regarding any concerns about SARs.

Reflection of the mother-daughter relationship on the perception of birth: a qualitative study among pregnant women.

This research is conducted to examine the effect of pregnant women's relationships with their mothers on their perception of birth. This is a qualitative analytic study. This research is carried out with 19 pregnant women who received service from a state hospital in a southern province of Turkey between November-December 2020.

Nurses' Knowledge and Practice of Nasogastric Tube Placement: A Descriptive Research Study.

The aim of this study is to examine nurses' knowledge and behaviors about nasogastric tube placement according to current standards. This descriptive study was conducted in a private hospital in Turkey with the participation of 184 nurses. Data were collected through a questionnaire consisting of two parts: "Personal Information Form" and "NGT Placement Information Form.

Bimodality and alternative equilibria do not help explain long-term patterns in shallow lake chlorophyll-a.

Since its inception, the theory of alternative equilibria in shallow lakes has evolved and been applied to an ever wider range of ecological and socioecological systems. The theory posits the existence of two alternative stable states or equilibria, which in shallow lakes are characterised by either clear water with abundant plants or turbid water where phytoplankton dominate. Here, we used data simulations and real-world data sets from Denmark and north-eastern USA (902 lakes in total) to examine the relationship between shallow lake phytoplankton biomass (chlorophyll-a) and nutrient concentrations across a range of timescales.

The Effect of Elasticity of Gelatin Nanoparticles on the Interaction with Macrophages.

Gelatin is a biocompatible, biodegradable, cheap, and nontoxic material, which is already used for pharmaceutical applications. Nanoparticles from gelatin (GNPs) are considered a promising delivery system for hydrophilic and macromolecular drugs. Mechanical properties of particles are recognized as an important parameter affecting drug carrier interaction with biological systems.

In Vitro Antiviral Evaluations of Coldmix: An Essential Oil Blend against SARS-CoV-2.

Coldmix is a commercially available and, blend for medicinal applications. In this present study, the in vitro antiviral potential of Coldmix, and its major constituents 1,8-cineole and α-pinene were evaluated by using the in vitro ACE2 enzyme inhibition assay as well as the direct contact test against SARS-CoV-2. The observed ACE2 enzyme inhibitory activity of Coldmix, 1,8-cineole, and α-pinene were 72%, 88%, and 80%, respectively; whereas in the direct contact test in the vapor phase, the destruction of the virus was 79.