Cardioprotective effects of H3 receptor activation could be double-sided: insights from isoproterenol-induced cardiac injury.

Histamine H3 receptors (H3Rs) are known to modulate neurotransmitter release in the nervous system, but their role in cardiac injury remains unclear. The present study aimed to investigate the cardioprotective role of H3Rs in a mouse model of myocardial injury. Forty BALB/c male mice were divided into four groups: Control (SF), Isoproterenol (ISO), Imetit (IMT), and IMT + ISO.

Global trends in technology-dependent children, home care, and parental discharge education: A bibliometric analysis using Biblioshiny.

Background: Parents of technology-dependent children constitute a different population in society and face diverse problems during caregiving.

Methods: This study aimed to identify and visualize studies conducted from 1990 to 2024 on technology-dependent children, home care, and parental discharge education and determine global trends. A descriptive and bibliometric study design was employed.

Heteroatom cobalt-based metal-organic framework and reduced graphene oxide nanocomposite for dispersive solid phase extraction of caffeine from exhaled breath condensate samples of premature infants prior to HPLC-PDA.

A cobalt-based metal-organic framework and graphene oxide were combined to prepare a new nanocomposite for extracting of caffeine from exhaled breath condensate (EBC) samples. Dispersive micro solid phase extraction of caffeine was conducted using the nanocomposite as a sorbent by adding 10 mg of it to the sample solution and vortexing for 3 min. After extracting of the analyte, it was eluted using the mobile phase.

Iliopsoas Tenotomy Does Not Negatively Affect Hip Flexion Strength in Crowe 3 and 4 Hips Undergoing Total Hip Arthroplasty.

Background: In total hip arthroplasty (THA), even if there is a dislocated hip, restoring the anatomical center of rotation increases long-term survival and hip function. Even with a shortening osteotomy, the procedure is still challenging due to soft-tissue tension. Therefore, soft tissue releases such as iliopsoas tenotomy may be necessary.

Internalizing disorders rather than ADHD are risk factors for chronicity in pediatric migraine patients.

Background/aim: Migraine is a prevalent neurological disorder that can lead to disability in children and adolescents. It is frequently accompanied by psychiatric comorbidities, both internalizing and externalizing disorders. While the relationship between migraine and internalizing disorders has been studied, there is limited research on the link between migraine and attention deficit hyperactivity disorder (ADHD).

Real-time fake news detection in online social networks: FANDC Cloud-based system.

Social networks have become a common way for people to communicate with each other and share ideas, thanks to their fast information-sharing features. But fake news spread on social networks can cause many negative consequences by affecting people's daily lives. However, the literature lacks online and real-time fake news detection systems.

Mapping the localization of the facial artery and vein at the inferior border of the mandible for clinical applications.

Aim: To spatially map the position of the facial artery and vein along the inferior border of the mandible based on specific facial reference points.

Methods: This cross-sectional study included 40 sides of 21 formalin-fixed cadaver heads (11 female, 10 male) with a mean age of 72.92 ± 11.

Risk Factors Affecting the Psychological Resilience of Adolescents in Institutional Care: A Systematic Review.

Background: Psychological resilience is defined as the resilience capacity and the power to recover in the face of stressful life events. Adolescents in institutional care have different individual, familial, and environmental risk factors that negatively affect their psychological resilience. This study aimed to comparatively examine studies that detect the risk factors affecting the resilience of adolescents living in institutional care and make recommendations regarding initiatives or specific outcomes related to this.

Deep neck infections mortal complications: Intrathoracic complications and necrotising fasciitis.

Background: We planned this study considering that complications of deep neck infections can be seriously life threatening.

Aim: To raise awareness that introthoracic complications and necrotizing fasciitis are causes of serious mortality and morbidity.

Methods: This study was carried out with the participation of 188 patients who were treated at Mersin University Department of Otorhinolaryngology and Head and Neck Surgery at January 1, 2024.

Turkish validity and reliability of the universal mental health literacy scale for adolescents (10-14 years): A methodological study.

Rationale: Mental health literacy enables adolescents to acquire information that will accompany them in their future lives and to define their attitudes and behaviors.

Aims And Objectives: This study evaluated the Turkish validity and reliability of the Universal Mental Health Literacy Scale for Adolescents (10-14 years).

Methods: This is a methodological, correlational, cross-sectional, and descriptive study.

Effects of Kinesio-taping and rigid-taping on vertical jump in individuals with pes planus: A randomised crossover comparison.

Introduction: The effects of Kinesio-taping (KT) and rigid-taping (RT) on vertical jump performance have been investigated; however, remain unclear. The study was designed to compare the effects of KT and RT on vertical jump in individuals with pes planus.

Methods: A total of 74 participants were diagnosed with pes planus.

A high voltage gain solid-state transformer for integration of renewable energy and AC sources.

This paper introduces a novel high-voltage gain topology for a solid-state transformer, integrating a DC-DC converter and dual active bridge converters. The proposed design features three DC links operating at different voltage levels. The first DC link connects to a single-switch high step-up DC-DC converter, while the second DC link interfaces with an AC source via a rectifier, allowing the use of both DC and AC inputs.

Protection by selective mTORC2 inhibition of Zymosan-induced hypotension and systemic inflammation mediated via IKKα/IκB-α/NF-κB activation.

Non-septic shock is a serious condition leading to multiple organ dysfunction. Although targeting the mammalian target of the rapamycin complex 1 (mTORC1) signaling pathway exerts potent anti-inflammatory activity, little is known about mTORC2's contribution to non-septic shock. Thus, our research aims to investigate mTORC2's contribution and associated changes of IκB kinase (IKKα)/inhibitor κB (IκB-α)/nuclear factor-ĸB (NF-κB) pathway on Zymosan (ZYM)-induced non-septic rat model using the novel mTORC2 selective inhibitor JR-AB2-011.

From Organotypic Mouse Brain Slices to Human Alzheimer's Plasma Biomarkers: A Focus on Nerve Fiber Outgrowth.

Alzheimer's disease (AD) is a neurodegenerative disease characterized by memory loss and progressive deterioration of cognitive functions. Being able to identify reliable biomarkers in easily available body fluids such as blood plasma is vital for the disease. To achieve this, we used a technique that applied human plasma to organotypic brain slice culture via microcontact printing.

Global Research Trends in Physical Activity Barriers: A Study on Men.

In this study, bibliometric properties of studies on physical activity barriers in men were analyzed using the Biblioshiny interface in R programming language. According to the results of the analysis, a total of 867 articles were published in 397 journals between 1992 and 2024. A great majority of the related studies were produced by American authors and institutions in the USA.

Exploring the Moderating Effect of Musculoskeletal Pain on Technostress-Induced Burnout: A Cross-Sectional Study of Bank Employees.

Background/objectives: Information and Communications Technology (ICT) advancements and high customer expectations are boosting the use of digital transformation and tech tools in business processes in a competitive environment. This trend enhances business effectiveness and efficiency but also introduces technostress as a new workplace stress factor. Technostress, defined as stress induced by using ICT in the workplace, has become increasingly prevalent in modern work environments, especially in sectors such as banking, due to digital transformation.

Phosphazene Tripeptide Conjugates: Design, Synthesis, In Vitro Cytotoxicity and Genotoxicity, Molecular Interactions in Binding Pockets on Human Breast and Colon Cancer Cell Lines.

The biological activity of both cyclophosphazenes and peptides makes these compounds important for new studies in medicinal chemistry. For this purpose, five different phosphazene-peptide conjugates synthesized from dichlorocyclotriphosphazene and tyrosine-containing tripeptides. The synthesized compounds were evaluated for their in vitro cytotoxic activities against human breast (MCF-7) and colon (Caco-2) cancer cell lines using MTT assay.

The effect of missed care on the nursing image perceived by patients and their trust relationships with nurses.

Background: Missed care has negative consequences for patients, directly affecting the quality of nursing care and patient safety.

Aim: This study investigated the effect of missed care on the nursing image perceived by patients and their trust relationships with nurses.

Methods: This descriptive and correlational study was conducted in all inpatient wards of a hospital in southern Türkiye.

Therapeutic implications of etiology-specific diagnosis of early-onset developmental and epileptic encephalopathies (EO-DEEs): A nationwide Turkish cohort study.

Objective: To evaluate the etiology-specific diagnosis of early-onset developmental epileptic encephalopathies (EO-DEEs) in a nationwide Turkish cohort to determine the implications for therapeutic management.

Methods: The cohort comprised 1450 patients who underwent EO-DEE. The utility of genetic testing was assessed with respect to the initial phases of next generation sequencing (NGS) (2005-2013) and the current NGS era (2014-2022).