598 results match your criteria: "Merkel Cell Tumors of the Head and Neck"
BMC Oral Health
December 2024
Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Objectives: Oral cancer (OC) is the most common malignant tumor of the head and neck (HN) and ranks 16th among the most frequently diagnosed cancers worldwide. A systematic review and meta-analysis aimed to provide an evidence-based analysis of the relationship between polyomaviruses and oral cancer.
Methods: The global online databases was used to identify relevant studies published between January 2000 and September 2024.
Clin Exp Dermatol
December 2024
Dermatology Department, Hospital Universitari de Bellvitge, Barcelona, Spain.
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine neoplasia. MCC complete spontaneous regression (CRS) has been linked to good prognosis. We conducted a retrospective review of a single-center cohort of MCC patients to analyze the characteristics of patients and tumors that exhibited regression.
View Article and Find Full Text PDFJ Med Virol
December 2024
Postgraduate Program in Translational Medicine, Departament of Medicine, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
Cancer Radiother
December 2024
Department of Radiation Oncology, Institut de cancérologie de Lorraine, Vandœuvre-lès-Nancy, France.
J Am Acad Dermatol
November 2024
Translation and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK; Department of Plastic and Reconstructive Surgery, Royal Victoria Infirmary, Newcastle Upon Tyne Hospital NHS Foundation Trust (NuTH), Newcastle upon Tyne, UK.
Oral Surg Oral Med Oral Pathol Oral Radiol
October 2024
Department of Oral Diagnosis, Semiology and Oral Pathology Areas, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil. Electronic address:
Int J Mol Sci
October 2024
Department of Experimental Oncology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wrocław, Poland.
The objective of our research was to determine the effects of xanthohumol (XN), a flavonoid isolated from hops (), and the anti-inflammatory drug niflumic acid (NA), separately and in combination with each other, on the proliferation of human cancer cells. Additionally, so as to understand the mechanism underlying the anticancer properties of the tested compounds, their effects on the biophysical parameters of a model membrane were assessed. The cells were incubated with XN and NA at various concentrations, either individually or in combination with each other.
View Article and Find Full Text PDFAnn Diagn Pathol
December 2024
Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
The parotid gland is a rare site for distant metastasis. We aim to provide an overview of metastatic tumours to the parotid over the past 20 years, focusing on clinicopathological analysis of 14 rare diagnoses. To the best of our knowledge, we are the first group to present the most up-to-date and largest case series on unusual metastases to the parotid.
View Article and Find Full Text PDFMod Pathol
November 2024
Department of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, Tours, France; "Biologie des infections à polyomavirus" Team, UMR INRA ISP 1282, Université de Tours, Tours, France.
Oral Oncol
October 2024
Medical Oncology Department, IOB Institute of Oncology-Madrid, Madrid, Spain.
Background: Merkel cell carcinoma (MCC) is an uncommon skin cancer that in more than 90 % of cases develops within the head and neck region. MCC is an aggressive disease with a dismal prognosis before the advent of immunotherapy. Avelumab, an anti-PDL1 agent is approved since 2017 for the treatment of advanced MCC after demonstrating a high response rate and favorable impact in survival.
View Article and Find Full Text PDFCancer Discov
September 2024
Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer with a ∼50% response rate to immune checkpoint blockade (ICB) therapy. To identify predictive biomarkers, we integrated bulk and single-cell RNA sequencing (RNA-seq) with spatial transcriptomics from a cohort of 186 samples from 116 patients, including bulk RNA-seq from 14 matched pairs pre- and post-ICB. In nonresponders, tumors show evidence of increased tumor proliferation, neuronal stem cell markers, and IL1.
View Article and Find Full Text PDFEur Arch Otorhinolaryngol
August 2024
Department of Otorhinolaryngology, Head and Neck Surgery, Head and Neck Center, Helsinki University Hospital and University of Helsinki, POB 263, 00029 HUS, Helsinki, Finland.
Purpose: Sinonasal lymphoma (SL) is a rare lymphatic neoplasm of the nasal cavities, paranasal sinuses and nasopharynx. Whereas some risk factors for SL subtypes have been identified, their aetiology is unknown. Along with other predisposing factors, the viral association of lymphomas, such as Epstein-Barr virus (EBV) and Burkitt and Hodgkin lymphomas, is well-established.
View Article and Find Full Text PDFESMO Open
May 2024
Division of Dermatology, Department of Medicine, University of Washington Medical Center at South Lake Union, Seattle, USA.
Laryngorhinootologie
May 2024
Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Universitätsklinikum Leipzig, Leipzig, Deutschland.
The interdisciplinary treatment of skin cancer in the head and neck area requires close collaboration between different specialist disciplines. The most common non-melanoma skin cancer tumor entities are cutaneous squamous cell carcinoma and basal cell carcinoma as well as their precursor lesions. One of the less common tumors is Merkel cell carcinoma, which also occurs primarily in light-exposed areas and, in contrast to squamous and basal cell carcinoma, is more likely to metastasize.
View Article and Find Full Text PDFCancer
August 2024
Harvard Medical School, Boston, Massachusetts, USA.
Am J Otolaryngol
June 2024
THANC (Thyroid, Head & Neck Cancer) Foundation, New York, NY, USA; Dept. of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Background: Merkel cell carcinoma (MCC) is an aggressive and rare neuroendocrine tumor, accounting for less than 1% of skin cancers. Metastasis primarily manifests in the cervical lymph nodes but rarely affect the thyroid.
Methods: We report a case of primary head and neck cutaneous MCC with metastasis to the thyroid gland.
Head Neck
October 2024
Institute of Pathology, Rostock University Medical Center, Rostock, Germany.
Background: Human papillomavirus (HPV) is an increasing risk factor for cancer. HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) is associated with a favorable outcome. Blockstaining for p16 is a surrogate marker for HPV+ OPSCC.
View Article and Find Full Text PDFCureus
February 2024
Dermatology, University of Texas Medical Branch, Galveston, USA.
Introduction Merkel cell carcinoma is an aggressive neuroendocrine tumor that is related to immunosuppression and the Merkel cell polyomavirus. It is more common on the head and neck and has been associated with other skin malignancies such as basal cell carcinoma, squamous cell carcinoma, and melanoma. However, there has never been a nationwide investigation that quantifies Merkel cell carcinoma's connection with these subgroups.
View Article and Find Full Text PDFJAAD Case Rep
March 2024
Department of Pathology and Laboratories, Fundación Santa Fe de Bogotá, Bogotá D.C., Colombia.
Laryngoscope
August 2024
Department of Otolaryngology - Head and Neck Surgery, Georgetown University Hospital, Washington, District of Columbia, U.S.A.
J Audiol Otol
July 2024
Department of Otorhinolaryngology-Head and Neck Surgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Clin Dermatol
July 2024
Department of Dermatology, University of Connecticut School of Medicine, Farmington, Connecticut, USA. Electronic address:
Curr Opin Otolaryngol Head Neck Surg
April 2024
Unit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili, Department of Surgical and Medical Specialties, Radiological Sciences, and Public Health, University of Brescia, School of Medicine, Brescia, Italy.
Purpose Of Review: This review critically assesses the current literature and guidelines, aiming to clarify some of the most important factors that impact surgical strategies of head and neck nonmelanoma skin cancers (NMSCs), focusing on squamous, basal, and Merkel cell carcinomas.
Recent Findings: Recent developments underscore the complexity of treatment for NMSC, particularly in the head and neck region. There is a lack of high-level evidence for the management of these tumors, especially in advanced stages.
Adv Radiat Oncol
February 2024
Department of Radiation Oncology, University of Washington, Seattle, Washington.
Purpose: The role of postoperative radiation therapy (PORT) in early stage Merkel cell carcinoma (MCC) is controversial. We analyzed the role of PORT in preventing local recurrences (LR) among patients with low-risk, pathologic stage I MCC based on the location of the primary tumors: head/neck (HN) versus non-HN sites.
Methods And Materials: One hundred forty-seven patients with MCC were identified that had "low risk" disease (pathologic T1 primary tumor, negative microscopic margins, negative pathologic node status, no immunosuppression or prior systemic therapy).