Altered anconeus muscle activation characteristics during isometric gripping in individuals with lateral elbow tendinopathy compared to age- and sex-matched control.

Purpose: Individuals with Lateral Epicondyle Tendinopathy (LET) commonly experience gripping deficits, which are marked by pain and altered motor control of the forearm extensors and flexors. Although delayed activation of the anconeus muscle during rapid wrist extension has been observed in LET, its role during gripping is not well understood. This study aimed to investigate anconeus activation and its relation to forearm muscle activity during gripping in individuals with LET.

Respiratory pathogen trends in queensland, australia between 2018 and 2021: A statewide cohort study before and after the initial COVID-19 outbreak.

Background: The SARS-CoV-2 pandemic and accompanying public health measures disrupted the normal transmission of respiratory viral pathogens. Less is known about the effects on bacterial pathogens.

Aims: To assess the impact of public health restrictions on common respiratory pathogens (influenza viruses, respiratory syncytial virus (RSV) and the following bacterial pathogens: Streptococcus pneumoniae (S.

Retrospective review of the development and implementation of a bedside tunneled dialysis catheter program.

Background: The decision to place a subcutaneously tunneled catheter is an infection prevention strategy for long term venous access allowing the proceduralist to access a vein and relocate the catheter exit site to a region on the body where care and maintenance can be safely performed. Subcutaneously tunneled centrally inserted dialysis catheter (ST-CIDC) placement is commonly performed in patients with renal disease and is traditionally performed with fluoroscopy in the interventional radiology suite or the operating theater. However, today's interventional radiologists and surgeons perform advanced invasive procedures that can be time-consuming resulting in delays in the scheduling of elective tunneled catheter placements.

Bacterial ghosts: A breakthrough approach to cancer vaccination.

Cancer is a devastating disease worldwide with high mortality rates and is a foremost concern for society. Immunotherapy has emerged as a promising strategy for treating cancer, harnessing the power of immune system to recognize and kill tumor cells. Bacterial ghosts (BGs), a novel platform in cancer vaccination, are suitable for personalized and effective immunotherapeutic interventions.

Young Australian drinkers' awareness, perceptions and behaviours towards low alcohol beverage products.

Young Australian drinkers (aged 18-24 years) are more likely to consume alcohol at risky levels than any other age group. The increased availability and diversity of low alcohol beverages (LAB)s available to Australian consumers presents an opportunity for young drinkers to moderate their drinking behaviours. To explore young risky drinkers' awareness, perceptions and behaviours towards LAB products.

An interprofessional multicomponent intervention to improve end-of-life care in intensive care: A before-and-after study.

Background: The provision of end-of-life care (EOLC) is an ongoing component of practice in intensive care units (ICUs). Interdisciplinary, multicomponent interventions may enhance the quality of EOLC for patients and the experience of family members and ICU clinicians during this period.

Objectives: This study aimed to assess the impact of a multicomponent intervention on EOLC practices in the ICU and family members' and clinicians' perceptions of EOLC.

Prolonged Taping with Exercise Therapy for Patellofemoral Pain in Adults: A Systematic Review and Single-Arm Meta-Analysis.

: To investigate the effects of prolonged taping on patellofemoral pain (PFP). : A literature search of PubMed, EMBASE (Elsevier), CiNAHL, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Scopus, and Web of Science was conducted from database inception to 28 June 2024. Eligible studies reported PFP patients over 18 years of age undergoing an exercise protocol with additional taping that was maintained outside of exercise sessions (PROSPERO ID: CRD42023422792).

Neck strength deficit is a risk factor for concussion in high school rugby union and rugby league players.

Objectives: Primary prevention of concussions is a priority in contact sports, with growing interest in the role of neck strength in mitigating the risks of concussion. The aim of this study was to determine if neck function was associated with in-season concussions in adolescent rugby union and league athletes, and to establish clinical values to identify players with increased risk of sustaining a concussion.

Design: Prospective cohort study.

Side Effects of Psychotropic Medications Experienced by a Community Sample of People Living With Severe and Persistent Mental Illness.

Background: Psychotropic medications are a common treatment modality for people living with severe and persistent mental illness (SPMI). While effective in reducing relapse and hospitalisation, psychotropic medications cause numerous side effects, varying in nature and severity. Identification and management of side effects is crucial in the ongoing management of SPMI.

The Urban Hospitalisation Experience of Rural People: A Scoping Review.

Background: Hospitalisation is often typically a stressful experience, but in the face of admission into hospital at a distance from home, the experience can be particularly anxiety-provoking.

Aim(s): To describe the urban hospitalisation experiences of rural patients and their relatives who have travelled and relocated for treatment and determine the scope and coverage of the literature on this issue.

Design: The review utilises a scoping review method.

Restructuring Biologically Assembled Binding Protein-Biopolymer Conjugates toward Advanced Materials.

Bacterial cell factories have been successfully engineered to efficiently assemble spherical polyhydroxybutyrate inclusions coated with functional proteins of interest. In these submicrometer-sized core-shell assemblies, proteins are bioconjugated to the polymer core, enabling bioengineering for uses as bioseparation resins, enzyme carriers, diagnostic reagents, and particulate vaccines. Here, we explore whether these functional protein-polymer assemblies could be restructured via dissolution and subsequent precipitation while retaining the functionality of the conjugated protein.

A Heat Sensitivity Scale for People with Parkinson's Disease.

Background: People living with Parkinson's disease (PD) commonly experience heat sensitivity-worsening symptoms and restricted daily activities in heat.

Objective: This study aimed to develop a scale of heat sensitivity for people with PD.

Methods: Through a search of the scientific literature and online forums, we developed 41 items relating to experiences of heat for people with PD to assess heat sensitivity.

The Experiences of Patients Who Participated in a Family Involvement Program After Abdominal Cancer Surgery: An Interpretative Phenomenological Analysis.

To prepare patients' families for active care roles after discharge, a family involvement program was developed. We aimed to gain in-depth insight into patients' well-being and experience during the program regarding the active involvement of family caregivers after oncological gastrointestinal cancer surgery during their hospital stay. Semi-structured interviews were conducted with 13 patients who participated in the program.

Influence of CAD/CAM diamond bur wear on the accuracy and surface roughness of dental ceramic restorations: A systematic review.

Objectives: To systematically review the current literature investigating the computer-aided design/computer-aided manufacturing (CAD/CAM) diamond bur deterioration with repeated use and its effects on the accuracy, marginal and internal fit, and surface roughness of the dental ceramic restorations from the subtractive manufacturing technique.

Materials And Methods: Three online databases, Ovid, Scopus, and Web of Science, were screened up to February 2024. In vitro studies investigating bur wear and its influences on subtractively-manufactured (SMed) ceramic restorations, except zirconia, were included.

Nationwide, Couple-Based Genetic Carrier Screening.

Background: Genomic sequencing technology allows for identification of reproductive couples with an increased chance, as compared with that in the general population, of having a child with an autosomal recessive or X-linked genetic condition.

Methods: We investigated the feasibility, acceptability, and outcomes of a nationwide, couple-based genetic carrier screening program in Australia as part of the Mackenzie's Mission project. Health care providers offered screening to persons before pregnancy or early in pregnancy.

New horizons in cancer immunotherapy: The evolving role of R848 and R837 (Review).

Therapeutic approaches that increase the efficacy and safety of cancer treatments and improve disease outcomes have been developed worldwide. Immunotherapy uses the body's immune system to inhibit cancerous growth in tissues and organs. Various approaches have been developed to effectively control and inhibit cancerous growth, including checkpoint inhibitors, T-cell transfer therapy, monoclonal antibodies, vaccines and immunomodulators.

Patient and Surgical Factors Associated With Long-Term Mortality Outcomes Up to Fifteen Years After Total Hip and Knee Arthroplasty: An Australian Orthopaedic Association National Joint Replacement Registry Study.

Background: Mortality rates following total hip arthroplasty (THA) and total knee arthroplasty (TKA) arthroplasty display distinct temporal patterns often attributed to patient selection bias, perioperative optimization, and comorbidities. Understanding these mortality patterns is essential for epidemiological and health economic longitudinal modeling.

Methods: We conducted a national registry-based cohort study in Australia using data from 1999 to 2022, examining primary and revision THA and TKA procedures for osteoarthritis.

Functionalisation of polyhydroxybutyrate for diagnostic uses.

Polyhydroxybutyrate (PHB) is a biodegradable and biocompatible biopolyester, naturally produced and self-assembled as spherical inclusions inside bacteria. These PHB particles contain a hydrophobic PHB core covalently coated with PHB synthase (PhaC), which serves as an anchoring linker for foreign proteins of interest. Protein engineering of PhaC enables the display of biologically active protein functions on the surface of PHB particles suitable for different applications.

Australian general practitioners' perception of modifiable risk factors in reducing infective complications following hip and knee joint replacement.

Background And Objectives: Smoking, poor diabetic control and excessive body mass index (BMI) increase the risk of infection following joint replacement. This study investigated Australian general practitioners' (GPs) perception of these modifiable risk factors in patients with end-stage osteoarthritis.

Method: A structured online survey tool was developed and widely distributed to Australian GPs.

Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition.

Aurora B kinase (AURKB) inhibitors have been trialled in a range of different tumour types but are not approved for any indication. Expression of the human papilloma virus (HPV) oncogenes and loss of retinoblastoma (RB) protein function has been reported to increase sensitivity to AURKB inhibitors but the mechanism of their contribution to sensitivity is poorly understood. Two commonly reported outcomes of AURKB inhibition are polyploidy and senescence, although their relationship is unclear.

Implementation of a risk-stratified intervention bundle to prevent pressure injury in intensive care: A before-after study.

Background: Hospital-acquired pressure injury is an enduring problem in intensive care. Several intensive care-specific pressure injury risk assessment tools have been developed, but to date, only the COMHON Index has been aligned with risk-stratified preventative interventions.

Objectives: The aim of this study was to evaluate the effectiveness of a risk-stratified intervention bundle to reduce pressure injury in intensive care and to assess compliance with bundled interventions.