Effect Modifiers and Risk Factors of Intraocular Inflammation Following Brolucizumab: A Systematic Review and Meta-analysis.

Purpose: To identify risk factors and effect modifiers associated with intraocular inflammation (IOI) following brolucizumab injection.

Methods: Our protocol was registered on PROSPERO (CRD42022382645). We searched six electronic databases (PubMed, Scopus, Web of Science, CENTRAL, EMBASE, and Google Scholar) to retrieve all studies that reported the occurrence of IOI following brolucizumab.

Effective Targeting of Raf-1 and Its Associated Autophagy by Novel Extracted Peptide for Treating Breast Cancer Cells.

Breast cancer is one of the most common causes of death in women worldwide and has harmful influence on their psychological state during therapy. Multikinase inhibitors have become effective drugs for treating a variety of cancer diseases such as breast cancer. A purified short peptide (H-P) was isolated from the natural honey and tested for its potential regulatory role in breast cancer cells compared with the effectiveness of the anticancer drug, Sorafenib (SOR), using MCF-7, EFM-19, and MCF-10A cell lines.

Improvement of the quality of buffalo's milk soft cheese by camel's whey protein concentrate.

Objective: The objective of this study was to investigate the impact of whey protein concentrate (WPC) derived from camel's milk on cheese yield, some chemical, microbial, and organoleptic properties of low salt soft cheese during refrigerated storage.

Materials And Methods: Cheeses made from buffalo's milk without and with adding 4,000 and 8,000 μg/ml WPC.

Results: Addition of WPC significantly increased the yield, titratable acidity, and decreased pH of the resultant cheese samples.

Elevated cystatin C: is it a reflection for kidney or liver impairment in hepatic children?

Aim Of The Study: To assess if elevated serum cystatin C (Cyst-C) is an indicator for renal or hepatic dysfunction in presence of liver fibrosis.

Material And Methods: Data of 50 children with chronic liver diseases (CLDs), out of which 25 were without renal impairment, and 25 with renal impairment were analyzed. Twenty healthy children served as a healthy control group.

Laser acupuncture as an adjunctive therapy for spastic cerebral palsy in children.

Laser acupuncture is widely used as an alternative line of treatment in several chronic pediatric diseases. To investigate whether biostimulation by low-level laser on acupuncture points adds a clinical benefit to conventional physiotherapy in hemiplegic spastic cerebral palsy (CP) children. Forty spastic hemiplegic cerebral palsy children by age 1-4 years were chosen from the pediatric outpatient clinic of the National Institute of Laser Enhanced Sciences (NILES), Cairo University, and Menofyia University hospitals.

Serum amyloid a gene polymorphism and its association with lipid profile in Saudi females with osteoporosis.

Background And Objective: Osteoporosis can be defined as a systemic skeletal disease characterized by low bone mass and micro architectural decline of bone tissue. Serum amyloid A (SAA) is a family of protein that increases up to 1,000-fold in blood during inflammation. In this study, we aimed to study the relationship between SAA1 gene polymorphism (rs12218) and lipid profile and osteoporosis.

Study of Sex Hormone-binding Globulin Gene Polymorphism and Risk of Type 2 Diabetes Mellitus in Egyptian Men.

Objectives: Conditions of hypoandrogenism in men have been linked to insulin resistance, suggesting that alterations in normal sex steroid physiology could play a role in the pathogenesis of Type 2 diabetes mellitus (T2DM). Sex hormone-binding globulin (SHBG) gene polymorphisms may be the cause of sex steroid alteration. The aim of this work is to study the effect of SHBG gene polymorphisms on the risk of T2DM through its impact on testosterone and oestradiol level in Egyptian men.

Laparoscopic trocar management of a giant paraovarian cyst: a case report.

A 17-year-old woman had undergone exploratory laparotomy because of a huge cystic pelviabdominal mass equivalent of 36 weeks' gestation. A closed system drainage maneuver was applied via using a laparoscopic trocar to drain a revealed large left paraovarian cyst. This maneuver was found to be a simple and effective method to safely aspirate giant paraovarian cysts; thus allowing their total excision.

WITHDRAWN: Immunogenicity and safety of HCV E1E2 peptide vaccine in chronically HCV-infected patients who did not respond to interferon based therapy.

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.

Antibiotic prophylaxis at elective cesarean section: a randomized controlled trial in a low resource setting.

Objective: To determine the best time to administer prophylactic antibiotics at Cesarean delivery in order to reduce the postoperative maternal infectious morbidity in a low resource setting.

Material And Methods: One hundred term primigravidae with singleton pregnancy were recruited and randomly allocated to two equal groups. Each woman received 2 g intravenous Cefazoline.

The relationship between term pre-eclampsia and the risk of early childhood caries.

Objective: To test the hypothesis that pre-eclampsia is associated with higher incidence of early childhood caries in children aged between 3 and 5 years old.

Design: An observational non concurrent cohort study.

Setting: Al-Hayat National Hospital, Khamees Mushyat, Saudi Arabic Kingdom.

Three-dimensional sonohysterography may replace hysteroscopy for women with perimenopausal bleeding.

Objective: To investigate whether three-dimensional saline-infusion transvaginal sonohysterography can replace hysteroscopy in the detection of intrauterine lesions in women with perimenopausal bleeding.

Materials And Methods: This study was carried out at the Department of Obstetrics and Gynecology, Menofyia University Hospital in Egypt. Fifty women who presented with perimenopausal bleeding and fulfilled the inclusion criteria were recruited for the study.

Abdominal electromyography in laboring and non-laboring pregnant women at term and its clinical implications.

Objective: To determine the patterns of uterine action potentials in laboring and non-laboring women at term using the non-invasive abdominal electromyography technique.

Methods: One hundred pregnant women at term who fulfilled the inclusion criteria were enrolled in the study and equally divided into two groups. Group I consisted of 50 women in active labor, while group II included 50 women not in labor.

Foley catheter versus intra-vaginal misoprostol for induction of labor in post-term gestations.

Objective: To investigate whether a fluid filled intra-uterine extra-amniotic Foley catheter is an effective alternative to vaginal misoprostol in inducing labor in primigravid women with post-term gestations.

Patients And Methods: A prospective quasi-randomized controlled trial was designed and 100 primigravid women with post-term gestations were enrolled and equally allocated into two groups. A fluid filled intra-uterine extra-amniotic Foley catheter was inserted in women of group I.

Female circumcision: Limiting the harm.

Objective: To review the strength of evidence that links many health hazards to female genital cutting.

Material And Methods: Literature search in Medline/Pubmed and Google scholar.

Results: Female genital cutting is still practiced secretly in both underdeveloped and developed countries due to prevailing strong traditional beliefs.

Medication errors in the obstetrics emergency ward in a low resource setting.

Objective: To investigate the patterns of medication errors in the obstetric emergency ward in a low resource setting.

Material And Methods: This prospective observational study included 10,000 women who presented at the obstetric emergency ward, department of Obstetrics and Gynecology, Menofyia University Hospital, Egypt between March and December 2010. All medications prescribed in the emergency ward were monitored for different types of errors.

Multiple tenotomies after Ponseti method for management of severe rigid clubfoot.

The purpose of the present study was to evaluate the efficacy of multiple tenotomies performed after application of the Ponseti method in reducing the tendency for recurrence in the severe rigid idiopathic clubfoot and limiting the need for application of the hyperabduction brace in the prewalking age. From November 2002 to December 2004, 30 severe (Pirani >5), rigid (nonresilient), idiopathic clubfeet in newly born infants aged 2 to 24 days were treated by the Ponseti method of weekly manipulations and castings until achieving full correction, apart from equinus. With the patient under general anesthesia, through 2 small incisions (2 cm), tenotomy of the Achilles tendon, tibialis posterior, and flexor digitorum longus was performed, together with posterior capsulotomy of the ankle to achieve >30° dorsiflexion in 26 feet.

Abdominal electromyography may predict the response to tocolysis in preterm labor.

Objective: To determine whether abdominal electromyography can predict the response to tocolysis in pregnant women in preterm labor.

Study Design: This study was carried out at the Department of Obstetrics and Gynecology, Menofyia University Hospital in Egypt. Fifty pregnant women in preterm labor who fulfilled the inclusion criteria were enrolled.

Circadian pattern of acute variceal bleeding among cirrhotic Egyptian patients.

Background: Liver cirrhosis is the most common cause of portal hypertension which may end in serious bleeding from gastro-esophageal varices. Recent studies have demonstrated a daily pattern of acute upper gastrointestinal bleeding in patients with liver cirrhosis evidenced by one or two peaks throughout the day.

Aim: The assessment of the circadian rhythm of acute variceal bleeding with the possible participation of circadian changes of the fibrinolytic parameters.

The combined effect of ketamine and remifentanil infusions as total intravenous anesthesia for scoliosis surgery in children.

Background: This study was designed to assess the effect of combination of ketamine and remifentanil infusions as total intravenous anesthesia (TIVA) during scoliosis surgery in children.

Methods: Thirty two children, 8-14 yr of age, scheduled for posterior spinal fusion, were randomly allocated into two equal groups to receive either remifentanil infusion in a dose of 0.2 microg/kg/minutes or same dose of remifentanil infusion combined with ketamine infusion in a dose of 1 microg/kg/minutes after induction of general anesthesia.

Hormonal and sonographic assessment of ovarian reserve before and after laparoscopic ovarian drilling in polycystic ovary syndrome.

This prospective observational study aimed to assess ovarian reserve after three different methods for induction of ovulation in 60 women between 30 and 40 years old with polycystic ovary syndrome. Women were equally divided into three groups. Group I included women who responded to clomiphene citrate.

Immunoreactivity evaluation of mutant p53 gene product with DNA ploidy pattern in colorectal carcinoma.

Background/aims: Studying p53 protein expression in tumor cells is one of the effective methods for detecting p53 gene mutations. This study attempted simultaneous monitoring of p53 overexpression in colon cancer using immunohistochemical and immunoblotting techniques and also to compare abnormalities of p53 with DNA ploidy and clinicopathological variables.

Methodology: The occurrence of p53 protein expression was analyzed in forty-nine fresh colorectal cancer specimens by immunohistochemical and p53 protein expression also demonstrated by Western immunoblotting technique in 28 colorectal cancer specimens, using an anti-human p53 monoclonal antibody (Do-7), and 25 normal colon mucosa as a negative control.