The Use of Transdermal Therapeutic Systems in Psychiatric Care: A Primer on Patches.

Background: Numerous currently available medications that act in the central nervous system can be delivered transdermally. Such medications include cholinesterase inhibitors for dementia, methylphenidate (MPH) for attention-deficit hyperactivity disorder, monoamine oxidase inhibitors (MAOIs) for depression, dopamine agonists for Parkinson disease and restless leg syndrome, and clonidine for attention-deficit hyperactivity disorder and impulse-control disorders.

Objective: This article aims to review the literature related to transdermal delivery systems from the perspective of clinical practice and research related to their use in the treatment of psychiatric conditions.

Increased prevalence of vegetarianism among women with eating pathology.

Objective: Prior research has established a link between vegetarianism and disordered eating but has typically sampled vegetarians. This study examined prevalence of and variables related to vegetarianism in three samples with varying severity of eating pathology.

Method: Sample 1 consisted of female undergraduates who denied history of or current disordered eating (i.

Addiction pharmacogenetics: a systematic review of the genetic variation of the dopaminergic system.

Substance use disorders have significant personal, familial, and societal consequences. Despite the serious consequences of substance use, only a few therapies are effective in treating substance use disorders, thus highlighting a need for improved treatment practices. Substance use treatment response depends on multiple factors such as genetic, biological, and social factors.

Neurocognitive status is associated with all-cause mortality among psychiatric, high-risk liver transplant candidates and recipients.

Objective: Judicious selection of potential liver transplant candidates and close monitoring of progress are essential to successful outcomes. Pretransplant psychosocial evaluations are the norm, but the relationship between psychosocial (and neurocognitive status) and longer term medical outcomes is understudied. This exploratory study sought to examine the relationship between objective measures of pretransplant psychosocial and neurocognitive status and service utilization, transplant status, and all-cause mortality.

Secure Attachment Moderates the Relation of Sexual Trauma With Trauma Symptoms Among Adolescents From an Inpatient Psychiatric Facility.

Experiencing sexual trauma has been linked to internalizing and externalizing psychopathologies. Insecure attachment has been shown to moderate the relation between sexual trauma and trauma symptoms among adults. However, few studies have explored relations among sexual trauma, attachment insecurity, and trauma symptoms in adolescence, and none have used developmentally appropriate measures.

Improvement in health-related quality of life among adults with serious mental illness receiving inpatient treatment: a prospective cohort study.

Objective: This study examined changes in health-related quality of life in adult inpatients with serious mental illness engaged in a 6- to 8-week intensive treatment program.

Method: Admission and discharge assessment with the MOS 36-item Short-Form Health Survey was completed (June 2010-June 2012) for 410 adults aged 18-68 years. Paired t tests and effect size estimates were calculated for the overall sample, and reliable change index scores and clinical significance were calculated to estimate individual-level response and recovery rates.

Pharmacogenomics in practice: a case report of personalized inpatient psychiatric care.

Given variable response to psychotropic intervention, this case highlights the potential of pharmacogenomics to inform medical decision-making in a male with atypical psychosis and depression with longer-standing attentional difficulties. Likely because of his specific COMT polymorphism and intermediate metabolizing liver enzymes, when the patient's stimulant medications were titrated to affect for attentional needs, he became psychotic secondary to a hyperdopaminergic state. Past prescriptions of dopaminergic antidepressant agents (e.

The Independent Contributions of Emotion Dysregulation and Hypermentalization to the "Double Dissociation" of Affective and Cognitive Empathy in Female Adolescent Inpatients With BPD.

Harari, Shamay-Tsoory, Ravid, and Levkovitz (2010) demonstrated a "double dissociation" in empathy in borderline personality disorder (BPD), such that BPD patients had higher affective than cognitive empathy, whereas controls exhibited the opposite pattern. Two processes that may relate to this dissociation are emotion dysregulation (ER) and hypermentalization. However, these interrelated processes have not been studied concomitantly, and the dissociation of empathy types has not been examined in adolescents with BPD.

Assessing relations between PTSD's dysphoria and reexperiencing factors and dimensions of rumination.

The purpose of the present study was to investigate the relations between posttraumatic stress disorder's (PTSD) dysphoria and reexperiencing factors and underlying dimensions of rumination. 304 trauma-exposed primary care patients were administered the Stressful Life Events Screening Questionnaire, PTSD Symptom Scale based on their worst traumatic event, and Ruminative Thought Style Questionnaire (RTSQ). Confirmatory factor analyses (CFAs) were conducted to determine the dysphoria and reexperiencing factors' relationships with the four factors of rumination.

The structure of personality pathology: Both general ('g') and specific ('s') factors?

Recent editions of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5; American Psychiatric Association, 2013) conceptualize personality disorders (PDs) as categorical constructs, but high PD co-occurrence suggests underlying latent dimensions. Moreover, several borderline PD criteria resemble Criterion A of the new DSM-5 Section III general criteria for personality pathology (i.e.

Implementation and effectiveness of integrated trauma and addiction treatment for incarcerated men.

A controlled trial of Seeking Safety (SS) and Male-Trauma Recovery Empowerment Model (M-TREM) examined implementation and effectiveness of integrated group therapy for comorbid post-traumatic stress disorder (PTSD) and substance use disorder (SUD) on PTSD and mental health symptoms plus self-esteem and efficacy for incarcerated men. The study sample (n=230) was male inmates 18 years or older who were primarily non-white, high school graduates or equivalents, had childhood trauma histories, committed violent crimes, had serious mental illnesses, and resided in a maximum security prison. Incarcerated men, who screened positive for PTSD and SUD, were assigned randomly (n=142) or by preference (n=88) to receive SS or M-TREM, with a waitlist group of (n=93).

Standards, accuracy, and questions of bias in Rorschach meta-analyses: reply to Wood, Garb, Nezworski, Lilienfeld, and Duke (2015).

Wood, Garb, Nezworski, Lilienfeld, and Duke (2015) found our systematic review and meta-analyses of 65 Rorschach variables to be accurate and unbiased, and hence removed their previous recommendation for a moratorium on the applied use of the Rorschach. However, Wood et al. (2015) hypothesized that publication bias would exist for 4 Rorschach variables.

Attachment insecurity and obsessive-compulsive personality disorder among inpatients with serious mental illness.

Background: Obsessive-compulsive personality disorder (OCPD) is characterized by traits such as extreme rigidity, perfectionism, and controlling behavior, all of which have a negative impact on interpersonal functioning. Attachment theory provides a useful framework to elucidate the interpersonal dysfunction characteristic of OCPD; yet, there is a dearth of attachment research on OCPD in the context of severe mental illness.

Methods: Attachment security and personality disorders were assessed in adult inpatients with severe mental illness.

Broad implications for respiratory sinus arrhythmia development: associations with childhood symptoms of psychopathology in a community sample.

Replicating the group-based developmental trajectory methodology from our prior study (Patriquin, Lorenzi, Scarpa, & Bell. 2014. Developmental Psychobiology, 56, 317-326), the current study examines the development of baseline respiratory sinus arrhythmia (RSA) across a new, larger cohort of typically developing children at 5, 10, 24, 36, and 48 months of age and examines the trajectory relationship with symptoms of childhood psychopathology.

Experiential avoidance mediates the link between maternal attachment style and theory of mind.

Theoretical and empirical models suggest a relation between attachment style and theory of mind (ToM) in childhood and adulthood; however, this link has not been evaluated to the same extent in adolescence. Additionally, these models typically fail to consider mechanisms by which attachment style affects ToM abilities. The present study sought to test a mediational model in which experiential avoidance mediates the relation between maternal attachment style and ToM.