7,892 results match your criteria: "Meningococcal Meningitis"
[Diagnosis of invasive Neisseria meningitidis infections].
Rev Prat
October 2024
Hôpital universitaire Robert-Debré, Paris, France. Groupe de pathologie infectieuse pédiatrique, France.
Article Synopsis
Characterisation and Immunogenicity of outer membrane vesicles displaying NadA, NHBA and fHbp from serogroup B.
Front Immunol
October 2024
Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Article Synopsis
- There is a need for more affordable and effective vaccines to prevent bacterial meningitis caused by serogroup B globally.
- The study explores the use of modified outer membrane vesicles (mOMVs) from commensal bacteria to elicit immune responses against meningococcal antigens, specifically various versions of factor H binding protein, Heparin Binding Antigen, and Adhesin A.
- The results showed that mice immunized with these engineered mOMVs produced antibodies to all targeted antigens and demonstrated significant serum bactericidal activity, indicating the potential of mOMVs for developing a protective vaccine against meningococcal disease.
activates pyroptotic pathways in a mouse model of meningitis: role of a two-partner secretion system.
Front Cell Infect Microbiol
October 2024
Department of Molecular Medicine and Medical Biotecnologies, University of Naples "Federico II", Naples, Italy.
Article Synopsis
- * A study using a reference strain and a knockout mutant showed that the HrpA/HrpB system is essential for disease progression, as the mutant exhibited impaired spreading and replication in the brain of infected mice.
- * Analysis of infected brain samples revealed that the mutant had reduced activation of key pyroptosis pathways and inflammatory markers, indicating that HrpA/HrpB is crucial for inducing pyroptosis during meningococcal infection.
Inequalities in the risk and prevention of invasive meningococcal disease in the United States - A systematic literature review.
Hum Vaccin Immunother
December 2024
GSK, Wavre, Belgium.
Article Synopsis
- * A systematic review identified that IMD incidence and mortality rates are higher in poorer neighborhoods and among specific racial and socioeconomic groups, with differences in vaccination rates based on income and education levels.
- * To address these inequalities, health policymakers should strengthen vaccination recommendations and improve public knowledge about IMD and its vaccines, especially for underrepresented and underserved populations.
Hajj vaccination strategies: Preparedness for risk mitigation.
J Infect Public Health
November 2024
King Salman Humanitarian Aid and Relief Center and College of Medicine, Al faisal University, Riyadh, Saudi Arabia; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA; Divisionof Infectious Diseases, Kyung Hee University, Seoul, South Korea.
Millions of pilgrims travel annually to Makkah and Madinah, Saudi Arabia, for the Hajj, posing unique challenges for public health management and disease control. The large influx of pilgrims from diverse backgrounds traveling to a confined geographic area, coupled with the close proximity and interactions among them, create significant pressure on the healthcare system and heighten the potential for the spread of communicable diseases. This review examines current trends in communicable diseases and their impact, drawing insights from expert perspectives on the required (i.
View Article and Find Full Text PDFCARD8 polymorphisms among bacterial meningitis patients in North-West Ethiopia.
BMC Infect Dis
October 2024
Department of Microbiology, University of Gondar, Gondar, Ethiopia.
Background: The severity of infectious disease outcomes is dependent on the virulence factors of the pathogen and the host immune response. CARD8 is a major regulator of the innate immune proinflammatory response and has been suggested to modulate the host response to common inflammatory diseases. In the present study, the C10X genetic polymorphism in the CARD8 gene was investigated in relation to bacterial meningitis.
View Article and Find Full Text PDFCharacteristics of children with invasive pneumococcal disease eligible for the 1+1 compared with the 2+1 PCV13 infant immunisation schedule in England: a prospective national observational surveillance study.
Lancet Child Adolesc Health
November 2024
Immunisation and Vaccine Preventable Diseases Division, UK Health Security Agency, London, UK; Centre for Neonatal and Paediatric Infections (CNPI), St George's University of London, London, UK. Electronic address:
Article Synopsis
- The UK shifted to a 1+1 infant immunization schedule for the PCV13 vaccine starting January 1, 2020, and a study analyzed its impact on invasive pneumococcal disease (IPD) in children aged 0-3 years.
- A comparison was made between a birth cohort eligible for the new 1+1 schedule and historical cohorts under the previous 2+1 schedule, examining various metrics like incidence rates and clinical outcomes.
- Findings showed no significant differences in IPD incidence, disease characteristics, or outcomes between the 1+1 and 2+1 cohorts after three years, indicating the new schedule did not adversely affect health outcomes in eligible children.
Article Synopsis
- Neisseria gonorrhoeae and N. meningitidis are closely related bacteria that cause gonorrhea and bacterial meningitis, respectively, and both affect different areas of the human body.
- Although effective vaccines exist for meningococcal disease, increasing antibiotic resistance highlights the urgent need for a vaccine against gonorrhea.
- This study explores the effectiveness of vaccines using TbpB combined with different adjuvants in mouse models, finding that certain adjuvants enhance protection against N. gonorrhoeae and N. meningitidis, suggesting a potential for a single vaccine to protect against both pathogens.
[Analysis on incidence trend of meningococcal meningitis and major pathogenic serogroups of in China, 1990-2023].
Zhonghua Liu Xing Bing Xue Za Zhi
September 2024
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing 102206, China Immunization Program Center, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
To understand the incidence trend of meningococcal meningitis from 1990 to 2023 and major pathogenic serogroups of () from 2006 to 2023 in China and the time trend of the incidence of meningococcal meningitis caused by main pathogenic serogroups, and provide reference for the prevention and control of meningococcal meningitis. The study used the data from "National Epidemic Data Compile" from 1990 to 2003 and the data from China Notifiable Infectious Disease Reporting System from 2004 to 2023 to analyze the incidence trend of meningococcal meningitis in China from 1990 to 2023 by Joinpoint regression method. Based on the data of the national meningococcal meningitis surveillance information reporting and management system from 2006 to 2023, the incidence of meningococcal meningitis caused by different serogroups of was described and analyzed, and the trend test was performed to analyze the change of the incidence of meningococcal meningitis caused by A, B, and C.
View Article and Find Full Text PDFMeningitis B vaccination.
CMAJ
September 2024
Department of Community Health & Epidemiology, College of Medicine (Rani, Hasselback), University of Saskatchewan; Saskatchewan Health Authority (Rani, Hasselback), Idylwyld Centre, Saskatoon, Sask.; School of Nursing, Faculty of Health Sciences (Coletto), University of Ottawa, Ottawa, Ont.
A perspective on the novel pentavalent Men5CV (NmCV-5) meningitis vaccine and Nigeria's pioneering rollout campaign.
Infez Med
September 2024
Community and Clinical Research Division, First On-Call Initiative, Port Harcourt, Nigeria.
The burden of meningitis poses great challenges for neurology and global health, manifesting with a range of symptoms from mild fever and headaches, to severe long term complications such as paralysis and cognitive impairment.. Unfortunately, those living in endemic regions, especially survivors, are often confronted with the harsh reality of reduced quality of life as measured by disability-adjusted life years.
View Article and Find Full Text PDFEconomic evaluation on meningococcal vaccination strategies among children under nine years of age in Zhejiang province, China.
PLoS One
September 2024
Institute of Immunization and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Article Synopsis
- The study evaluates the cost-effectiveness of using a new meningococcal vaccination strategy (MCV-ACWY and MPV-ACWY) compared to the current strategy (MPV-A and MPV-AC) in China's national immunization program.
- Utilizing a decision tree-Markov model, the research predicts that the new strategy could prevent 513 disease cases, 53 long-term health issues, and 47 deaths in a birth cohort from 2023.
- The new vaccination approach has a more favorable cost-effectiveness ratio ($16,899.81/QALY), with a 55.98% probability of being cost-effective, compared to only 14.76% for the current strategy, despite its
Preferences of US adolescents and parents for vaccination against invasive meningococcal disease.
Vaccine
November 2024
Evidera, London, United Kingdom.
Article Synopsis
- - **Low Vaccination Rates**: The text discusses the low uptake of meningococcal vaccines in the US and emphasizes the importance of understanding factors influencing vaccination preferences to potentially increase these rates.
- - **Study Design and Findings**: A study was conducted with adolescents and their guardians to assess their willingness to vaccinate based on various vaccine attributes, highlighting that 59.5% of participants favored vaccination regardless of the attributes presented.
- - **Key Influencing Factors**: The findings revealed that the key factors affecting vaccination choice were the vaccine's level of protection and the likelihood of mild-to-moderate side effects, with a new pentavalent vaccine option further boosting willingness among specific demographics.
Article Synopsis
- Central nervous system infections are a significant health concern, particularly in infants, where early detection is crucial.
- Doctors may start with empirical antibiotics, but it's essential to carry out diagnostic tests to tailor the treatment effectively.
- Reporting these cases helps gather important data for public health and can inform decisions about vaccination strategies for the community.
Article Synopsis
- The study focuses on identifying risk factors and clinical characteristics of seasonal meningitis outbreaks in Ghana’s Upper West Region, which lies within the African meningitis belt.
- A case-control study was conducted with laboratory-confirmed meningitis cases and matched controls to explore associations with demographic, clinical, and lifestyle factors.
- Key findings revealed that exposure to tobacco smoke, overcrowded living conditions, and the presence of sore throat infections were significant risk factors, while the most common symptoms among patients were headache, fever, and neck pain.
Public health management of invasive meningococcal disease outbreaks: worldwide 1973-2018, a systematic review.
BMC Public Health
August 2024
School of Public Health, The University of Adelaide, Level 4 50 Rundle Mall Plaza, Rundle Mall, Adelaide, South Australia, 5000, Australia.
Article Synopsis
- Infectious diseases like Invasive Meningococcal Disease (IMD) pose ongoing public health challenges due to their severe impact and the fact that they're not fully vaccine-preventable.
- A systematic review of 39 studies on IMD outbreaks revealed that most public health responses were reactive rather than proactive, often affecting entire communities instead of focusing on high-risk groups.
- The findings highlighted a critical need for better reporting standards and comprehensive data to improve public health responses for IMD and future infectious disease outbreaks.
[Community-Acquired Bacterial Meningoencephalitis: The New Guideline].
Dtsch Med Wochenschr
August 2024
Institut für Neuroimmunologie und Multiple Sklerose, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.
Article Synopsis
Angiopoietin-like 4 protects against endothelial dysfunction during bacterial sepsis.
Nat Microbiol
September 2024
Institut Cochin, Université Paris Cité, CNRS, Inserm, Paris, France.
Loss of endothelial integrity and vascular leakage are central features of sepsis pathogenesis; however, no effective therapeutic mechanisms for preserving endothelial integrity are available. Here we show that, compared to dermal microvessels, brain microvessels resist infection by Neisseria meningitidis, a bacterial pathogen that causes sepsis and meningitis. By comparing the transcriptional responses to infection in dermal and brain endothelial cells, we identified angiopoietin-like 4 as a key factor produced by the brain endothelium that preserves blood-brain barrier integrity during bacterial sepsis.
View Article and Find Full Text PDF[Meningococcal meningitis in Chile between 1990 and 2019].
Andes Pediatr
June 2024
Universidad San Sebastián, Santiago, Chile.
Unlabelled: Since 1941, outbreaks of Neisseria meningitidis have been recorded in Chile which, to date, have varied according to clinical form, incidence, lethality, and the responsible serogroup.
Objective: To summarize the available evidence on the epidemiological profile of acute bacterial meningitis due to Neisseria meningitidis in Chile, analyzing the incidence between 1990 and 2019.
Method: A systematized review of primary articles was carried out following the Cochrane Collaboration standards.
Genetic characterization and estimated 4CMenB vaccine strain coverage of 284 isolates causing invasive meningococcal disease in Argentina in 2010-2014.
Hum Vaccin Immunother
December 2024
Instituto Nacional de Enfermedades Infecciosas-ANLIS "Dr. Carlos G. Malbrán", Buenos Aires, Argentina.
Article Synopsis
- The study investigates the diversity of Meningococcal serogroup B (MenB) strains in Argentina and assesses vaccine coverage using genetic tools like gMATS and human serum bactericidal antibodies (hSBA).
- Researchers analyzed 284 MenB isolates, identifying that the four main clonal complexes represented over 81% of the samples, with varying antigen profiles for vaccine candidates.
- Results showed that the 4CMenB vaccine could potentially cover approximately 61.3% of strains based on gMATS predictions and 78.4% based on hSBA assay, highlighting the need for ongoing genomic monitoring of MenB in Argentina.
Emerging Meningococcal B Meningitis in Japan: A Case Report of a 50-Year-Old Japanese Man with Diabetes.
Am J Case Rep
July 2024
Department of Infectious Diseases, St. Luke's International Hospital, Tokyo, Japan.
Article Synopsis
- - Meningococcal meningitis outbreaks in Japan are typically caused by locally infected individuals, not those traveling internationally, as highlighted by a case of a diabetic man in his 50s who developed symptoms without recent travel history.
- - Diagnosis involved detecting gram-negative diplococci in cerebrospinal fluid, with positive results from multiplex PCR testing; despite negative results from blood cultures, the patient was treated effectively with ceftriaxone and discharged with some lingering symptoms.
- - The case underlined a gap in vaccine availability against serogroup B meningococcal infections, prompting a review of Japan's vaccination strategies and infection control measures to mitigate risks and improve responses to future outbreaks.
Maternal skepticism regarding children's vaccination in Jordan: Investigating the knowledge, attitude, and adherence.
PLoS One
July 2024
Department of Paramedicine, Monash University, Clayton, Victoria, Australia.
Article Synopsis
- Vaccination is essential for effective healthcare, but many parents globally, especially mothers, are skeptical about vaccinating their children, impacting adherence rates.
- A study assessed the knowledge, attitudes, and adherence to routine and elective vaccinations among 533 Jordanian mothers, finding high levels of awareness and adherence to routine vaccines but only moderate adherence to elective ones.
- The study highlighted the need for targeted health education campaigns to address misconceptions and improve understanding, particularly around elective vaccines, by utilizing primary healthcare centers and physicians as key information sources.
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) Initially Presenting as Septic Meningoencephalitis in a 16-Year-Old Male.
Eur J Case Rep Intern Med
June 2024
Department of Acute Medicine, Watford General Hospital, Watford, UK.
Background: We describe a case of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) in a 16-year-old patient who initially presented with clinical features of septic meningoencephalitis. This case outlines the importance of considering a diagnosis of MOGAD in patients who fail to improve with appropriate antimicrobial therapy or show a positive clinical response to glucocorticoids (often used in treatment of meningococcal meningitis). We emphasise the importance of recognising that an infectious prodrome can precede MOGAD.
View Article and Find Full Text PDFManagement of Adults With Bacterial Meningitis in the Emergency Department.
Cureus
June 2024
Emergency Medicine, Leicester Royal Infirmary, Leicester, GBR.
Introduction: The Leicester Royal Infirmary Emergency Department is one of the largest single-site Emergency Departments in the UK. We evaluated the department's management of bacterial meningitis. The current national guideline recommends that all patients presenting with suspected bacterial meningitis receive antibiotics within one hour.
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