Mechanical Thrombectomy for High-Risk Pulmonary Embolism: Insights From the US Cohort of the FLASH Registry.

Background: Acute mortality for high-risk, or massive, pulmonary embolism (PE) is almost 30% even when treated using advanced therapies. This analysis assessed the safety and effectiveness of mechanical thrombectomy (MT) for high-risk PE.

Methods: The prospective, multicenter FlowTriever All-comer Registry for Patient Safety and Hemodynamics (FLASH) study is designed to evaluate real-world PE patient outcomes after MT with the FlowTriever System (Inari Medical).

Disparities by sex, race, and region in acute myocardial infarction-related outcomes during the early COVID-19 pandemic: the national inpatient sample analysis.

Background: Disparities in acute myocardial infarction (AMI)-related outcomes have been reported before the COVID-19 pandemic. We studied in-hospital outcomes of AMI across demographic groups in the United States during the early COVID-19 pandemic.

Methods: The National Inpatient Sample (NIS) database was queried for 2020 to identify AMI-related hospitalizations based on appropriate ICD-10-CM codes categorized by sex, race, and hospital region categories.

Sex and Racial Disparities in Proportionate Mortality of Premature Myocardial Infarction in the United States: 1999 to 2020.

Background: The incidence of premature myocardial infarction (PMI) in women (<65 years and men <55 years) is increasing. We investigated proportionate mortality trends in PMI stratified by sex, race, and ethnicity.

Methods And Results: CDC WONDER (Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research) was queried to identify PMI deaths within the United States between 1999 and 2020, and trends in proportionate mortality of PMI were calculated using the Joinpoint regression analysis.

Longer-Term Outcomes Following Mechanical Thrombectomy for Intermediate- and High-Risk Pulmonary Embolism: 6-Month FLASH Registry Results.

Background: Mechanical thrombectomy provides rapid hemodynamic improvements after acute pulmonary embolism (PE), but long-term benefits are uncertain.

Methods: FlowTriever All-comer Registry for Patient Safety and Hemodynamics is a prospective, single-arm, multicenter registry of patients with acute PE treated with the FlowTriever System (Inari Medical). Six-month outcomes including modified Medical Research Council dyspnea scores (MMRCD), right ventricular (RV) function, 6-minute walk test distances, and PE quality-of-life scores (QoL) were assessed.

Updated feasibility and reproducibility results of multi-institutional study of noninvasive breast tumor bed boost.

Purpose: To report updated feasibility and reproducibility results for high-dose-rate noninvasive breast brachytherapy (NIBB) for tumor bed boost with whole breast radiation therapy (WBRT) in the setting of expanded patient and treatment facility number.

Methods And Materials: Fifteen independent community-based and academic centers reported 518 early-stage breast cancer patients from July 2007 to February 2015 on a privacy-encrypted online data registry. All patients' treatment included lumpectomy followed by combination of WBRT and NIBB.

Incidence, risk factors and management of delayed wound dehiscence after craniotomy for tumor resection.

Dehiscence after a wound has healed is a known complication of craniotomy for tumor resection. We conducted a retrospective analysis of 64 patients who underwent craniotomy for tumor resection followed by radiation or radiosurgery between 2006 and 2010. Five patients (7.

CyberKnife radiosurgery for management of intracranial perineural spread of cutaneous malignancies.

Intracranial perineural spread (PNS) is a rare complication of cutaneous malignancies and refers to access of the tumor to the intracranial space typically by tracking along cranial nerves. Patients are usually treated with palliative external-beam radiotherapy or with radiosurgery if there has been prior standard radiotherapy. Two patients are presented, both with cranial neuropathies occurring years after treatment for cutaneous malignancies.

Oncomodulatory mechanisms of human cytomegalovirus in gliomas.

Human cytomegalovirus (HCMV), a widespread beta-herpes virus, infects a high percentage of high grade gliomas. Although HCMV is not recognized as an oncogenic virus, it might increase the malignancy of the infected cell by disrupting cellular pathways involved in the cell cycle, apoptosis, angiogenesis, cell invasion and the host immune response. This article reviews the recent evidence of the modulatory effects of HCMV infection leading to the malignant progression of gliomas and explores novel therapeutic targets against such lethal tumors.

Klebsiella pneumoniae Carbapenemase-producing Enterobacteriaceae, Northeast Florida.

Background: Since 2001 there have been several reported outbreaks due to carbapenem-resistant Klebsiella pneumoniae (Kp), particularly in the northeastern states.

Methods: Carbapenemase-producing Enterobacteriaceae from healthcare facilities in Northeast Florida were phenotypically identified and confirmed using PCR amplification and sequencing of the blaKPC gene.

Results: Results from PFGE analysis of these isolates demonstrated possible horizontal spread from two possible "outbreak" strains during the study period.

Relationship of neural stem cells with their vascular niche: implications in the malignant progression of gliomas.

During embryogenesis and in regions of the adult brain undergoing post-natal neurogenesis, neural stem cells and endothelial precursors are found within a vascular niche, where the coordinated interactions between neurogenesis and vasculogenesis dictates development and responses to the environment. Moreover, recent evidence suggests that gliomas may arise from transformed neural stem cells and that angiogenesis is important in the malignant progression of these tumors. Taken together, these findings have led researchers to focus on the dynamic interaction between neural stem cells and their vascular niche so as to find new therapeutic strategies to halt the progression of gliomas.

Endoscope-assisted posterior approach for the resection of ventral intradural spinal cord tumors: report of two cases.

We report our experience with the removal of ventral intradural spinal tumors through a posterior approach with the assistance of an endoscope. The endoscope allowed us to remove the tumor with minimal retraction of the spinal cord and to inspect for involvement of structures that were difficult to visualize with the microscope. Moreover, it obviated the use of a more involved anterior approach.

Biology of the subventricular zone in relation to gliomagenesis.

There is recent compelling evidence that gliomas arise from neural stem cells residing in the lining of the lateral ventricles, known as the subventricular zone, that have undergone malignant transformation. This article reviews the operative elements, including cytoskeletal proteins, tumor suppressor genes, cell adhesion molecules, growth factors, transcription factors and developmental pathways that link the subventricular zone to gliomagenesis. It is hoped that with an improved understanding of the putative source of gliomas, new therapeutic strategies will be developed against such deadly tumors.

Vascular complications after radiosurgery for meningiomas.

During the past 25 years, radiosurgery has evolved as a primary treatment modality for certain meningiomas when resection would be associated with high patient morbidity. In addition, radiosurgery is now routinely used as an adjunctive therapy for residual or recurrent meningiomas after surgical removal. In this review the authors summarize the vascular complications that occur after radiosurgery for meningiomas as well as experimental study data that give insight into the pathogenesis of this complication.

An evidence-based approach to case management model selection for an acute care facility: is there really a preferred model?

Purpose Of Study: This research seeks to determine whether there is adequate evidence-based justification for selection of one acute care case management model over another.

Primary Practice Setting(s): Acute Inpatient Hospital.

Methodology And Sample: This article presents a systematic review of published case management literature, resulting in classification specific to terms of level of evidence.

The role of cadherins and catenins in gliomagenesis.

Cell-cell adhesion is a crucial process occurring during normal tissue development. Cadherins are calcium-dependent cell-surface adhesion molecules involved in cell-cell adhesion. They reorganize the actin cytoskeleton via interaction with the catenins.