243 results match your criteria: "Member of the German Centre for Lung Research[Affiliation]"

Invasive infections with Aspergillus fumigatus in ICU patients are linked to high morbidity and mortality. Diagnosing invasive pulmonary aspergillosis (IPA) in non-immunosuppressed patients is difficult, as Aspergillus antigen (galactomannan [GM]) may have other causes. This retrospective study analyzed 160 ICU surgical patients with positive GM in broncho-alveolar lavage fluid (BALF), classifying them based on AspICU criteria for suspected IPA (pIPA) or aspiration.

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Unlabelled: In 2022, over 1,000,000 people from Ukraine fled to Germany, mostly women and children. The aim of this study was to determine health status and socio-demographic background of Ukrainian refugee minors in Germany and to compare that to German minors. In this study, Ukrainian refugees of all ages, who voluntarily made contact with the study centres via flyers or refugee shelters, were interviewed with the help of trained interpreters from 09-12/2022.

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Background: Humans are subjected to various environmental stressors (bacteria, viruses, pollution) throughout life. As such, an inherent relationship exists between the effect of these exposures with age. The impact of these environmental stressors can manifest through DNA methylation (DNAm).

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Diffusion capacity and static hyperinflation as markers of disease progression predict 3-year mortality in COPD: Results from COSYCONET.

Respirology

October 2024

Department of Medicine, Pulmonary and Critical Care Medicine, Clinic for Airway Infections, University Medical Centre Marburg, Philipps-University Marburg, Marburg, Germany.

Background And Objective: Chronic obstructive pulmonary disease (COPD) exhibits diverse patterns of disease progression, due to underlying disease activity. We hypothesized that changes in static hyperinflation or KCO % predicted would reveal subgroups with disease progression unidentified by preestablished markers (FEV, SGRQ, exacerbation history) and associated with unique baseline biomarker profiles. We explored 18-month measures of disease progression associated with 18-54-month mortality, including changes in hyperinflation parameters and transfer factor, in a large German COPD cohort.

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[Radiology of bronchiectasis].

Radiologie (Heidelb)

November 2024

Hannover Medical School, Institute for Diagnostic and Interventional Radiology, Carl-Neuberg-Str. 1, 30629, Hannover, Deutschland.

Bronchiectasis is an irreversible bronchial dilatation. It is chronically progressive through a vicious circle of secretion retention, infection, inflammation and structural damage. The underlying causes are diverse and the severity of the disease is variable, which makes both the diagnostics and treatment challenging.

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Article Synopsis
  • The study investigates how sex influences the outcomes of patients undergoing prolonged weaning from invasive ventilation, utilizing a retrospective analysis at a hospital in Germany.
  • Out of 785 patients, both men and women showed relatively high rates of successful weaning (77.9% for women and 75.4% for men), with sex not identified as a significant risk factor for weaning failure.
  • Key risk factors differed between sexes: for men, age and duration of ventilation were critical, while for women, previous non-invasive ventilation, critical illness polyneuropathy, and delirium played significant roles.
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Article Synopsis
  • STAT3 gain-of-function syndrome is an immune disorder that results in various immune system issues, often requiring immunomodulatory treatments like blocking interleukin-6 receptors or using JAK inhibitors (JAKi).
  • A study at Hannover University involved seven patients with STAT3-GOF, where five were treated with JAK inhibitors, leading to positive outcomes for many autoimmune and inflammatory symptoms.
  • Overall, JAKi treatment showed significant improvement for the majority of patients, but more long-term studies are necessary to understand the risks associated with extended use.
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Introduction: The primary analysis (median follow-up 34.9 mo across all arms) of the phase 3 POSEIDON study revealed a statistically significant overall survival (OS) improvement with first-line tremelimumab plus durvalumab and chemotherapy (T+D+CT) versus CT in patients with EGFR and ALK wild-type metastatic NSCLC (mNSCLC). D+CT had a trend for OS improvement versus CT that did not reach statistical significance.

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Association between right heart size and right ventricular output reserve in patients with pulmonary arterial hypertension.

Int J Cardiol

December 2024

Centre for Pulmonary Hypertension, Thoraxklinik Heidelberg GmbH at Heidelberg University Hospital, Heidelberg, Germany; Translational Lung Research Centre Heidelberg (TLRC), Member of the German Centre for Lung Research (DZL), Heidelberg, Germany; Department of Pneumology and Critical Care Medicine, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Germany. Electronic address:

Objectives: Right ventricular (RV) output reserve, defined as increase of cardiac output during exercise, is reduced in patients with pulmonary arterial hypertension (PAH). Aim of this study was to evaluate the association of right heart size measured by echocardiography and invasively measured RV function at rest and during exercise in PAH patients.

Methods: Adult PAH-patients who received routine haemodynamic assessment at rest and during exercise by right heart catheterisation and echocardiographic measurement of right heart size (right atrial (RA) and RV area) were included in this study.

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Objectives: In patients with non-tuberculous mycobacterial pulmonary disease (NTM-PD), the response to treatment is evaluated based on microbiological, clinical, and radiological data. However, little is known about the dynamics of CT findings. The aim of this study was to evaluate CT changes in NTM-PD in order to define radiological criteria for treatment success.

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Sex-Differences in Alpha-1 Antitrypsin Deficiency: Data From the EARCO Registry.

Arch Bronconeumol

January 2025

Department of Pneumology and Critical Care Medicine, Thoraxklinik University of Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany. Electronic address:

Article Synopsis
  • The study investigated the differences in chronic obstructive pulmonary disease (COPD) between genders in patients with alpha-1 antitrypsin deficiency (AATD) using data from the EARCO registry.
  • It analyzed 1283 AATD patients and found that while women reported less smoking and alcohol consumption, they had a higher prevalence of bronchiectasis despite better lung function.
  • Results indicated that women experienced a similar symptom burden as men but had higher rates of exacerbations, suggesting that treatment approaches may need to be adjusted for female patients.
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Objectives: 3D phase-resolved functional lung (PREFUL) MRI offers evaluation of pulmonary ventilation without inhalation of contrast agent. This study seeks to compare ventilation maps obtained from 3D PREFUL MRI with a direct ventilation measurement derived from Xe MRI in both patients with chronic obstructive pulmonary disease (COPD) and healthy volunteers.

Methods: Thirty-one patients with COPD and 12 healthy controls underwent free-breathing 3D PREFUL MRI and breath-hold Xe MRI at 1.

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Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging.

J Vis Exp

June 2024

Institute of Diagnostic and Interventional Radiology, Hannover Medical School; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Centre for Lung Research (DZL).

Pulmonary magnetic resonance imaging (MRI) offers a variety of radiation-free techniques tailored to assess regional lung ventilation or its surrogates. These techniques encompass direct measurements, exemplified by hyperpolarized gas MRI and fluorinated gas MRI, as well as indirect measurements facilitated by oxygen-enhanced MRI and proton-based Fourier decomposition (FD) MRI. In recent times, there has been substantial progress in the field of FD MRI, which involved improving spatial/temporal resolution, refining sequence design and postprocessing, and developing a comprehensive whole-lung approach.

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Eosinopenia as Predictor of Disease Severity in Patients With Community-Acquired Pneumonia: An Observational Study.

Chest

December 2024

Department of Medicine, Pulmonary and Critical Care Medicine, Clinic for Airway Infections, University Medical Centre Marburg, Philipps-University Marburg, Marburg, Germany; CALM-QE network; Institute for Lung Research, Universities of Giessen and Marburg Lung Centre, Marburg, Germany; German Centre for Lung Research (DZL) and Member of the German Centre of Infectious Disease Research, Marburg, Germany; Centre for Synthetic Microbiology (Synmikro), Philipps-University Marburg, Marburg, Germany. Electronic address:

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Background: Pulmonary perfusion defects have been observed in patients with coronavirus disease 2019 (COVID-19). Currently, there is a need for further data on non-contrast-enhanced MRI in COVID patients. The early identification of heterogeneity in pulmonary perfusion defects among COVID-19 patients is beneficial for their timely clinical intervention and management.

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Endothelin and the tumor microenvironment: a finger in every pie.

Clin Sci (Lond)

June 2024

Lung Microenvironmental Niche in Cancerogenesis, Institute for Lung Health (ILH), Justus Liebig University, Giessen, Germany.

The tumor microenvironment (TME) plays a central role in the development of cancer. Within this complex milieu, the endothelin (ET) system plays a key role by triggering epithelial-to-mesenchymal transition, causing degradation of the extracellular matrix and modulating hypoxia response, cell proliferation, composition, and activation. These multiple effects of the ET system on cancer progression have prompted numerous preclinical studies targeting the ET system with promising results, leading to considerable optimism for subsequent clinical trials.

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Estimation of Cerebral Blood Flow Using the Pulse Wave Amplitude in Brain MRI.

Acad Radiol

July 2024

Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany; Biomedical Research in End-stage and Obstructive Lung Disease Hannover (BREATH), Member of the German Centre for Lung Research (DZL), Hannover, Germany.

Rationale And Objectives: First, to test the feasibility of cerebral blood flow (CBF) estimation using the pulse wave amplitude in flow-related enhancement (FREE) brain MRI in comparison to pseudo-continuous arterial spin labeling (pCASL-MRI). Second, the potential for acceleration was evaluated retrospectively.

Materials And Methods: 24 healthy study participants between 20 and 61 years had cerebral MRI.

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Background: Dyspnoea is a common symptom of respiratory disease. However, data on its prevalence in general populations and its association with lung function are limited and are mainly from high-income countries. The aims of this study were to estimate the prevalence of dyspnoea across several world regions, and to investigate the association of dyspnoea with lung function.

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Three-dimensional (3D) echocardiography-derived right ventricular (RV) ejection fraction (EF) and global longitudinal strain (GLS) are valuable RV functional markers; nevertheless, they are substantially load-dependent. Global myocardial work index (GMWI) is a novel parameter calculated by the area of the RV pressure-strain loop. By adjusting myocardial deformation to instantaneous pressure, it may reflect contractility.

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BACKGROUND: Chronic obstructive pulmonary disease (COPD) in adults is a result of environmental risk factors and genetic factors. Polygenic COPD risk scores are highly predictive for lung function in adults. We hypothesized that a polygenic COPD risk score is also predictive for lung function in children who are born preterm.

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Article Synopsis
  • Combining ICS (a type of medicine) with long-acting bronchodilators (LABD) helps people with COPD have fewer flare-ups than just using LABD alone.
  • The study compared the risk of getting pneumonia between patients using ICS with a special medicine called ef-BDP and those only using LABD.
  • Results showed that using ef-BDP/LABD didn't increase the chance of getting pneumonia compared to LABD alone, which is a good sign for people with COPD.
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Background: Chronic cough is a common respiratory symptom with an impact on daily activities and quality of life. Global prevalence data are scarce and derive mainly from European and Asian countries and studies with outcomes other than chronic cough. In this study, we aimed to estimate the prevalence of chronic cough across a large number of study sites as well as to identify its main risk factors using a standardised protocol and definition.

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Background: Non-contrast-enhanced H magnetic resonance imaging (MRI) with full lung coverage shows promise for assessment of regional lung ventilation but a comparison with direct ventilation measurement using F MRI is lacking.

Purpose: To compare ventilation parameters calculated using 3D phase-resolved functional lung (PREFUL) MRI with F MRI.

Study Type: Prospective.

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To analyze cerebral arteriovenous pulse propagation and to generate phase-resolved pulse amplitude maps from a fast gradient-echo sequence offering flow-related enhancement (FREE). Brain MRI was performed using a balanced steady-state free precession sequence at 3T followed by retrospective k-space gating. The time interval of the pulse wave between anterior-, middle- and posterior cerebral artery territories and the superior sagittal sinus were calculated and compared between and older and younger groups within 24 healthy volunteers.

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