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Role of education and differentiation in determining the potential of natural killer cells to respond to antibody-dependent stimulation.
AIDS
November 2014
aDepartment of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne bBurnet Institute, Melbourne cMelbourne Sexual Health Centre, Carlton, Victoria, Australia.
Antibody-dependent activation of natural killer (NK) cells might facilitate protective outcomes in the context of HIV exposure or infection. Antibody-dependent activation is heightened in NK cells educated by interactions between killer immunoglobulin-like receptors (KIRs) and their major histocompatibility complex class I ligands during ontogeny. Differentiated NK cells, defined as CD57, also exhibit enhanced antibody-dependent responsiveness.
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