440 results match your criteria: "Melanotic Neuroectodermal Tumor of Infancy"
Clinicopathological study of a rare neuroectodermal neoplasm of the cranium.
Childs Nerv Syst
December 2024
Department of Neuropathology, National Institute of Mental Health and Neurosciences, Hosur Road, Bengaluru, 560029, India.
Purpose: Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, rapidly growing pigmented neoplasm originating from the neural crest. Predominantly affecting infants, it commonly occurs in the head and neck region. MNTI is often locally aggressive with a high recurrence rate.
View Article and Find Full Text PDFMelanotic neuroectodermal tumor of infancy (MNTI) is a rare distinctive neoplasm of infants with rapid expansile growth and a high rate of recurrence. Most commonly, the lesion affects the maxilla followed by the skull and orbit. One such case was diagnosed in a 5-month-old boy who presented with rapidly enlarged swelling over the back of the skull.
View Article and Find Full Text PDFMelanotic neuroectodermal tumor of infancy: A case report.
Asian J Surg
October 2024
Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. Electronic address:
Operative Technique for Extirpation of Large Melanotic Neuroectodermal Tumor of Infancy Involving Alveolus and Anterior Maxilla in the Region of the Premaxilla.
J Craniofac Surg
October 2024
Department of Surgery, Division of Plastic Surgery, Nemours Children's Hospital, Wilmington, DE.
Article Synopsis
- * A case study of a 10-week-old boy presented an aggressively growing tumor, leading to a carefully planned surgical resection involving innovative techniques such as a piezoelectric saw to ensure precise removal without damaging surrounding structures.
- * The complete excision of the tumor was successful with negative margins, emphasizing that thorough removal is crucial to prevent recurrence, and demonstrating the advantages of advanced surgical tools for better patient outcomes.
Melanotic neuroectodermal tumor of infancy: a case report.
J Med Case Rep
May 2024
Department of Pediatrics, Medical Faculty, Tikur Anbesa Specialized Hospital, Addis Ababa University, Addis Ababa, Ethiopia.
Article Synopsis
- Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, benign, pigmented tumor originating from neural crest cells, often found in the maxilla, and can be mistaken for other malignant tumors.
- A 5-month-old Ethiopian infant was diagnosed with MNTI after a mass on the forehead was surgically removed and analyzed, confirming the diagnosis through histology and immunohistochemistry.
- Ongoing monitoring is essential for infants like this patient, as MNTI can recur, and it should be included in differential diagnoses for head region tumors in infants.
Melanotic Neuroectodermal Tumor of Infancy of Jaws: A Case Report and Review of Literature.
Cureus
March 2024
Department of Oral and Maxillofacial Surgery, King George's Medical University, Lucknow, IND.
Article Synopsis
- - Melanotic neuroectodermal tumor of infancy (MNTI) is a rare tumor primarily affecting infants, and a case report details successful surgical treatment of an 11-month-old girl.
- - A review of 250 MNTI cases found that the tumor mainly occurs in the anterior maxilla of infants under six months, and recurrence rates are influenced by age and treatment choices.
- - The study noted a 2.4% mortality rate, a 2% rate of malignancy, and a 15.2% recurrence rate, with recommendations for follow-up monitoring lasting between four months to two years to track potential recurrences.
Melanotic neuroectodermal tumor of infancy arising in the skull: a case report.
Pan Afr Med J
April 2024
Department of Neurosurgery, Ibn Tofail Hospital, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy in Marrakech, Cadi Ayyad University, Marrakech, Morocco.
Article Synopsis
- Melanotic neuroectodermal tumor of infancy is a rare, usually benign growth found in young children, primarily in the head and neck region.
- A case study highlights a 3-month-old girl with a growing mass on her forehead, which was found to be pressing on nearby structures during an MRI.
- After partial removal of the tumor confirmed the diagnosis, the patient experienced a recurrence, emphasizing the need for early diagnosis and surgical intervention to reduce risks of progression and reappearance.
A Rare Melanotic Neuroectodermal Tumor of Infancy in a 3-month-old Child: A Case Report.
Int J Clin Pediatr Dent
January 2024
Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Dental College and Hospital, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra, India.
Article Synopsis
- * A CT scan revealed a benign lesion that was successfully surgically removed.
- * Histopathological analysis confirmed the tumor type, and follow-up after six months showed no signs of recurrence.
Melanotic Neuroectodermal Tumor of Infancy: A Case Image.
Head Neck Pathol
March 2024
Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro, R. Rodolpho Paulo Rocco, n. 325, 1st floor, Cidade Universitária, Rio de Janeiro, RJ, CEP: 21.941-902, Brazil.
Article Synopsis
- Melanotic neuroectodermal tumor of infancy (MNTI) is a rare benign tumor that can mimic malignant conditions, often causing confusion among healthcare providers.
- A case involving a 2-month-old infant with an extensive 10 cm tumor protruding from the anterior maxilla and cheek is reported, which caused displacement of the nose.
- After surgical removal of the tumor, the patient showed no signs of recurrence during a 6-month follow-up, highlighting the need for early diagnosis and treatment for better outcomes.
Article Synopsis
- Neonatal alveolar lymphangioma (NAL) is a rare benign growth typically found in the mouths of newborns, especially those of African descent.
- A case study discusses bilateral NAL with imaging follow-ups at 6 and 17 months, highlighting differential diagnoses like dental lamina cyst and hemangioma.
- Accurate clinical identification of NAL is crucial, as biopsies are generally not needed, with follow-up recommended for one year or until the condition resolves.
Melanotic Neuroectodermal Tumor of Infancy in the Epididymis: A Case Report.
Int J Surg Pathol
April 2024
Department of Pathology, The First Bethune Hospital of Jilin University, Changchun, China.
Article Synopsis
- Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, non-cancerous tumor that primarily affects the head and face, with only a few cases reported in the epididymis.
- A notable case involved a 5-month-old boy diagnosed with MNTI in his epididymis, who then underwent surgery (orchiectomy) and has shown no signs of tumor recurrence after six months.
- It is important for healthcare providers to consider MNTI in the differential diagnosis when infants have rapidly enlarging lumps in the scrotal area, as it can be mistaken for a malignant condition.
Long term follow-up results of enucleation as the definitive treatment for melanocytic neuroectodermal tumour of infancy and a review on its treatment.
J Oral Biol Craniofac Res
March 2023
Division of Oral and Maxillofacial Pathology, CDER, All India Institute of Medical Sciences, India.
Article Synopsis
- * Five cases of MNTI in young infants presented as painless, large bluish-brown swellings, with imaging showing well-defined lesions affecting the orbit and nasal area; all tumors were removed surgically without recurrence in follow-ups of up to 5 years.
- * Diagnosis involves histopathological and immunohistochemical analysis to confirm MNTI and distinguish it from other malignant tumors, and while enucleation is the primary treatment, long-term
Melanotic Neuroectodermal Tumour of Infancy.
Head Neck Pathol
June 2023
Department of Oral & Maxillofacial Surgery, Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, AIMS Campus, Kochi, India.
Article Synopsis
- Melanotic neuroectodermal tumour of infancy (MNTI) is a mostly benign, locally aggressive tumor that primarily affects infants under one year old, particularly in the head and neck region, with the anterior maxilla being the most common site.
- The tumor consists of two types of cells: neuroblastic and pigmented epithelial cells, and while it appears benign, it can invade surrounding tissues like muscle and bone, complicating diagnosis.
- Treatment typically involves surgical excision, which is usually effective, but early diagnosis is crucial to avoid complications related to growth and reconstruction in infants.
Melanotic neuroectodermal tumor of infancy: A narrative review of dental aspects.
Saudi Dent J
January 2023
Department of Pediatric Dentistry, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Article Synopsis
- * Despite being benign, MNTIs can grow quickly, pose a risk of recurrence, and disrupt essential functions like feeding and breathing, while also damaging nearby tissues.
- * The study focuses on the pathology, clinical presentation, treatment strategies for MNTIs, and highlights the important role dentists play in managing these cases.
Melanotic neuroectodermal tumor of infancy. Clinical case of large fontanel tumor and literature review.
Zh Vopr Neirokhir Im N N Burdenko
December 2022
Blokhin National Medical Research Center of Oncology, Moscow, Russia.
Article Synopsis
- Melanotic neuroectodermal tumor of infancy (MNTI) is a type of tumor common in newborns, known for its rapid growth and tendency to come back after treatment.
- In this case, a 6-month-old boy had surgery to remove the tumor located on his skull, but it recurred just 3 weeks later, leading to a second surgery and radiation therapy.
- After 6 months of follow-up, there was no tumor growth, but overall, the best treatment approach for MNTI remains uncertain based on limited information.
Maxillary Melanotic Neuroectodermal Tumour of Infancy Managed by Local Excision.
Indian J Otolaryngol Head Neck Surg
October 2022
Departments of Pediatric Surgery, Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry, 605006 India.
Article Synopsis
A case report of melanotic neuroectodermal tumor of infancy complicated with congenital heart disease and hypothyroidism.
Front Cardiovasc Med
November 2022
Department of Pathology, Tianjin Children's Hospital (Tianjin University Children's Hospital), Tianjin, China.
Article Synopsis
- The case report presents a unique instance of melanotic neuroectodermal tumor of infancy (MNTI) in a 9-month-old girl, who also has tetralogy of Fallot (TOF) and congenital hypothyroidism (CH).
- It was found that a lower dosage of levothyroxine (L-T4) for CH slowed MNTI growth, while the standardized dosage improved thyroid function but led to rapid MNTI progression.
- The study highlights the significant impact of thyroid hormone on MNTI growth and emphasizes the need for careful management of co-existing health issues in pediatric MNTI cases.
Computed tomographic imaging features of maxillary and mandibular melanotic neuroectodermal tumor of infancy: Report of 2 cases and systematic review.
Oral Surg Oral Med Oral Pathol Oral Radiol
October 2022
Section of Hospital Dentistry, Division of Oral and Maxillofacial Radiology, Columbia University Irving Medical Center, New York, New York, USA. Electronic address:
Article Synopsis
- This systematic review aimed to identify the CT imaging features of melanotic neuroectodermal tumor of infancy (MNTI) in the maxilla and mandible, including two cases from the researchers' institution.
- The review analyzed 52 studies consisting of 53 MNTI cases using various reputable databases, focusing on the diagnostic quality of CT imaging.
- Key findings showed that common CT features include bone expansion, a well-defined periphery, tooth displacement, and a bilocular radiolucent internal pattern; notably, the bilocular pattern was previously unrecognized and can aid in diagnosing MNTI when linked with an expansile mass in infants.
Melanotic neuroectodermal tumor of infancy (MNTI) - A rare entity.
J Cancer Res Ther
August 2022
Department of Peadriatic Surgery, KGMU, Lucknow, Uttar Pradesh, India.
Article Synopsis
- Melanotic neuroectodermal tumor of infancy is a rare and aggressive pigmented tumor primarily found in the maxilla of infants, distinguished by its neural crest origin and diverse cellular markers.
- The tumor grows rapidly and destructively, leading to a high likelihood of recurrence and malignant transformation if left untreated.
- In a case study, a 2-month-old boy underwent successful wide local excision and chemotherapy, showing promising recovery without signs of recurrence or metastasis during follow-up.
Clinical and imaging features of melanotic neuro-ectodermal tumor of infancy of the maxillary bone: report of four cases and review of the literature.
Oral Radiol
October 2022
Department of Stomatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Article Synopsis
- Melanotic neuro-ectodermal tumor of infancy (MNTI) is a rare tumor that typically occurs in infants under 6 months old, characterized by a rapidly-growing, non-ulcerated soft tissue swelling with pigmented mucosa.
- A study of four patients revealed distinctive imaging features using ultrasound, CT, and MRI, including osteolytic maxillary bone destruction and specific signal intensities on MRI scans.
- Recognizing the imaging characteristics along with clinical history is essential for diagnosing MNTI, as there are no signs of metastasis in affected patients.
Melanotic Neuroectodermal Tumor of Infancy: A Rare Case Report.
Asian J Neurosurg
March 2022
Department of Neurosurgery, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Article Synopsis
- * It primarily develops in craniofacial regions, particularly in the maxilla, but can also be found in the epididymis, testis, ovaries, and bones of the limbs.
- * MNTI typically affects infants under 1 year old, with a slight predominance in males, and the report details an unusual case of a child with a midline frontal MNTI.
Melanotic Neuroectodermal Tumor of Infancy: the Use of Immunohistochemical Analysis.
Acta Stomatol Croat
June 2022
Morphofunctional Sciences, Institute of Higher Education of Vale do Parnaiba, Brazil, ORCID: https://orcid.org/0000-0002-6577-2816.
Article Synopsis
- MNTI is a fast-growing, pigmented tumor found in infants that often doesn't show symptoms but can be aggressive and cause local tissue damage.
- Imaging exams can indicate malignant potential by showing signs of bone remodeling and destruction, helping in early diagnosis.
- This study emphasizes the importance of histopathological analysis and immunohistochemistry for accurately diagnosing MNTI and identifying potential aggressive growth.
Melanotic neuroectodermal tumor of infancy: Case report and literature review.
Ear Nose Throat J
July 2022
State Key Laboratory of Military Stomatology, Department of Oral and Maxillofacial Surgery, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Fourth Military Medical University, Xi'an, China.
Article Synopsis
- Melanotic neuroectodermal tumor of infancy (MNTI) is a rare and benign tumor primarily affecting infants, often located in the maxilla (upper jaw).
- The report details one specific case, covering the diagnosis, treatment, and various features of the tumor, including clinical, pathological, and imaging characteristics.
- The discussion also addresses the treatment options and overall prognosis for patients with MNTI.
Mandibular Melanotic Neuroectodermal Tumor of Infancy: Interdisciplinary Treatment from 2 Months to 19 Years of Age.
J Maxillofac Oral Surg
March 2022
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Article Synopsis
- Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, benign tumor that usually arises in the anterior maxilla, but in this case, it developed in the mandible of a 2-month-old patient with rapid growth.
- The diagnosis was confirmed through MRI and elevated urine vanillylmandelic acid (VMA) levels, leading to a comprehensive treatment plan involving four interventions.
- The treatment entailed initial surgery, orthodontic care from ages 7 to 15, pre-prosthetic surgery to prepare the mandible, and finally, the placement of permanent prosthetic restorations supported by implants.