1,468 results match your criteria: "Melanoma Ciliary Body"
Sympathetic ophthalmia in a patient with ciliary body melanoma and extraocular extension.
Can J Ophthalmol
December 2024
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address:
Diffuse iris melanoma leading to secondary glaucoma in a lion (Panthera leo)-A case report.
Vet Ophthalmol
December 2024
Departamento de Medicina Veterinária, Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Article Synopsis
- - A 12-year-old male African lion was diagnosed with eye issues, including discharge and swelling, leading to the discovery of an intraocular mass via ocular ultrasonography.
- - The lion underwent enucleation (removal of the eye), and histopathological analysis confirmed the presence of diffuse iris melanoma, a type of cancer affecting the iris and ciliary body.
- - While diffuse iris melanoma is common in domestic cats, it's rarely seen in larger felids like lions, and more research is needed to understand its impact and prognosis in these animals.
Clinical features of midzonal iris pigment epithelial cysts: surprising findings revealed by ultrasound biomicroscopy.
Graefes Arch Clin Exp Ophthalmol
November 2024
Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267-0527, USA.
Article Synopsis
- The study examined midzonal iris pigment epithelial (IPE) cysts, which are usually harmless but can be confused with ciliary body melanoma, to better understand their characteristics using ultrasound biomicroscopy (UBM).
- Researchers reviewed 69 patient charts, finding that cysts were most common in older adults (median age 66), with a slight female majority and various cyst sizes, often located inferotemporally in the eye.
- UBM revealed that many cases thought to have multiple cysts were actually single cysts with distinct shapes, and associated peripheral IPE cysts were found in a majority of the evaluated eyes.
Impact of COVID-19 on uveal melanoma in France.
J Fr Ophtalmol
November 2024
Ophthalmology Department, Centre Hospitalier Universitaire de Nice, Université Côte d'Azur, Nice, France; Department of Biology and Pathologies of Melanocytes, Team1, Équipe Labellisée Ligue 2020 and Équipe Labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Inserm, Nice, France. Electronic address:
Purpose: Treatment delays due to the COVID-19 pandemic in uveal melanoma (UM) patients have led to an increased rate of enucleations in Europe. The impact of multiple COVID-19 lockdowns on UM management has not been assessed in France. The goal of this study was to assess whether delayed diagnosis could have led to more advanced stages and thus a higher rate of enucleations.
View Article and Find Full Text PDFPlaque Radiotherapy for Ocular Melanoma.
Cancers (Basel)
October 2024
Department of Ophthalmology, National University Health System, Singapore 119228, Singapore.
Article Synopsis
- Plaque radiotherapy is a targeted treatment for medium-sized ocular tumors like uveal melanoma, using customized plaques to deliver precise radiation while minimizing damage to surrounding healthy tissue.
- The choice of radioisotope, such as Ruthenium-106 or Iodine-125, is based on factors like tumor characteristics and desired treatment duration, with high dose rate (HDR) options facilitating quicker treatment.
- Efficacy of Ruthenium-106 varies significantly, and outcomes can be influenced by tumor size, thickness, and location; however, plaque brachytherapy can offer similar survival rates to more invasive treatments like enucleation for suitable cases.
Impact of Metastatic Pattern on Survival in Patients with Posterior Uveal Melanoma: A Retrospective Cohort Study.
Cancers (Basel)
September 2024
Department of Ophthalmology, Copenhagen University Hospital-Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark.
Article Synopsis
- Metastatic posterior uveal melanoma (PUM) has a short median survival, but some patients live longer, prompting this study to explore if the location of metastases affects survival rates.
- The study analyzed 178 patients divided into three groups: those with only liver metastases (hepatic), those with both liver and other metastases (hepatic-extrahepatic), and those with only non-liver metastases (extrahepatic).
- Results showed that patients with extrahepatic metastases had a significantly longer median survival (17 months) compared to those with liver-only (11 months) or combined liver and other (7 months) metastases, highlighting the importance of anatomical location in prognosis.
Gain of chromosome 8q and high expression of EZH2 may predict poor prognosis in Chinese patients with uveal melanoma.
Asia Pac J Ophthalmol (Phila)
October 2024
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PR China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200011, PR China. Electronic address:
Article Synopsis
- The study aimed to identify risk factors for poor prognosis in uveal melanoma among a Chinese population, focusing on the genetic markers monosomy 3, 8q gain, and EZH2 staining.
- Examining 89 patient cases from 2012 to 2021, researchers conducted immunohistochemical analysis and evaluated survival rates using statistical methods like Kaplan-Meier and Cox regression.
- Key findings indicated that factors such as age, tumor size, stage, and the presence of 8q gain and high EZH2 expression were linked to higher rates of distant metastasis, while monosomy 3 showed no significant association in this study.
[Uveal Melanoma: Molecular and Genetic Mechanisms of Development and Therapeutic Approaches].
Mol Biol (Mosk)
October 2024
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, 630090 Russia.
Article Synopsis
- * The cancer's molecular mechanisms are not well understood, but mutations in the GNAQ and GNA11 genes are prevalent, and a specific signaling pathway is crucial for tumor development.
- * Current therapies for metastatic uveal melanoma (MUM) are limited, though research is focused on targeted drugs and immunotherapies, with an emphasis on identifying genetic mutations for predicting metastasis risk and guiding treatment decisions.
Ciliary body myxoid epithelioid sarcoma in a cat: a case report.
BMC Vet Res
October 2024
Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Article Synopsis
- A rare myxoid intraocular neoplasm originating from the ciliary body was discovered in a 14-year-old female cat, characterized by a bubble-shaped mass that led to secondary glaucoma and necessitated enucleation.
- Histological and immunohistochemical analysis revealed a multinodular hypocellular neoplasm with strong cytokeratin and vimentin reactivity, suggesting an epithelioid myxosarcoma diagnosis.
- The case highlights the need to consider epithelioid myxosarcoma in differential diagnoses for feline intraocular tumors and stresses the importance of early surgical intervention to prevent further complications.
Impact of Tumor Pigmentation in 6934 Patients with Uveal Melanoma at a Single Center.
Ophthalmol Sci
July 2024
Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, 14th Floor, Philadelphia, Pennsylvania, 19107.
Article Synopsis
- The study aimed to assess how the degree of pigmentation in uveal melanoma (UM) tumors affects clinical features and outcomes in 6,934 patients from an ocular oncology center between 1971 and 2007.
- Results showed that pigmented tumors were linked to higher rates of extraocular extension, faster recurrence, and a greater 10-year metastasis rate (26%) compared to partially pigmented (19%) and nonpigmented (16%) tumors.
- The analysis utilized various statistical methods, including survival analysis and regression, indicating significant differences in outcomes related to tumor pigmentation, impacting prognosis for patients.
Pathological findings in enucleated eyes of patients with neurofibromatosis type 1: report of a case with 15-year follow-up and review of 14 patients in the literature.
BMC Ophthalmol
August 2024
Department of Neurological Surgery, General Medical Center, Kawasaki Medical School, Okayama City, 700-8505, Japan.
Article Synopsis
- Iris nodules are common in neurofibromatosis type 1, but other eye issues are rare; this study highlights a patient with a phthisic eye who had it removed for cosmetic reasons after 15 years.
- The case focuses on a 17-year-old male who underwent multiple surgeries due to complications, including total retinal detachment, with the enucleated eye showing signs of massive retinal gliosis and no apparent neurofibromas in some areas.
- A review of 14 similar cases revealed a pattern of eye conditions like glaucoma and neurofibromas in certain structures, indicating various ocular manifestations of neurofibromatosis type 1.
15-Gene Expression Profile and as Integrated Prognostic Test for Uveal Melanoma: First Report of Collaborative Ocular Oncology Group Study No. 2 (COOG2.1).
J Clin Oncol
October 2024
Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX.
PURPOSEValidated and accurate prognostic testing is critical for precision medicine in uveal melanoma (UM). Our aims were to (1) prospectively validate an integrated prognostic classifier combining a 15-gene expression profile (15-GEP) and RNA expression and (2) identify clinical variables that enhance the prognostic accuracy of the 15-GEP/ classifier.MATERIALS AND METHODSThis study included 1,577 patients with UM of the choroid and/or ciliary body who were enrolled in the Collaborative Ocular Oncology Group Study Number 2 (COOG2) and prospectively monitored across 26 North American centers.
View Article and Find Full Text PDFCiliary body melanoma: multimodal composition.
Arch Soc Esp Oftalmol (Engl Ed)
November 2024
Servicio de Oftalmología, Hospital General Universitario de Valencia, Valencia, Spain.
Aim: To demonstrate a rare case of ciliary body leiomyoma in our patient Case report: A 72-year-old female reported to our clinic for a preventive examination, upon which we found a dome-shaped grey-brownish mass on the retinal periphery. After completing gonioscopic and ultrasound examinations, we referred the patient to a specialist facility. Due to a finding of suspicious malignant melanoma, we completed the MRI scan and recommended enucleation of the eyeball.
View Article and Find Full Text PDFHigh-Dose-Rate Yttrium-90 (Y) Episcleral Plaque Brachytherapy for Iris and Iridociliary Melanoma.
Ophthalmol Sci
March 2024
The Department of Ocular Tumor, Orbital Disease, and Ophthalmic Radiation Therapy, The New York Eye Cancer Center, New York, New York.
Article Synopsis
- - This pilot study explored the use of high-dose-rate yttrium-90 (Y) plaque brachytherapy as a treatment for iris and iridociliary melanoma in six patients diagnosed through clinical examination or biopsy.
- - The procedure involved staging tumors and conducting the treatment with a focus on various factors such as tumor size and patient demographics, while also monitoring for complications like inflammation or cataract progression.
- - Results showed effective tumor control with fast treatment times (average 8.8 minutes) and minimal side effects, indicating that high-dose-rate brachytherapy could be a promising option for managing small melanomas without extensive surgical procedures.
Anterior segment swept-source optical coherence tomography and ultrasound biomicroscopy in iris and ciliary body lesions.
Expert Rev Med Devices
May 2024
Department of Pathology, Ankara University Faculty of Medicine, Ankara, Turkey.
Article Synopsis
- The study aimed to differentiate between benign and malignant eye lesions in the iris and ciliary body by comparing two imaging techniques: anterior segment swept-source optical coherence tomography (AS SS-OCT) and ultrasound biomicroscopy (UBM).
- A retrospective evaluation of 42 eyes revealed various tumor types, with both imaging methods providing 100% visualization of the anterior tumor margin, but UBM being better for posterior margin visualization in certain types of tumors.
- The findings suggest that while UBM is the preferred method for imaging these tumors, AS SS-OCT is a viable alternative, especially for less prominent iris lesions.
Extensive intraocular melanoma with secondary glaucoma in a 15-month-old Thoroughbred filly.
Vet Med Sci
May 2024
Department of Rossdales Laboratories, Rossdales Equine Hospital and Diagnositc Centre, Newmarket, UK.
Article Synopsis
- A 15-month-old Thoroughbred filly was diagnosed with glaucoma in the right eye, which was linked to a mass in the anterior chamber causing corneal edema and blepharospasm.
- Following treatment for the secondary glaucoma, the mass was identified as a likely intraocular melanoma, leading to an enucleation procedure.
- Histopathological analysis confirmed it as a unique case of invasive uveal melanoma, highlighting the importance of considering this diagnosis in glaucoma cases in young horses.
A Choroidal Melanoma With Ciliary Body Involvement in a Young Female.
Cureus
March 2024
Department of Ophthalmology, Hospital Raja Permaisuri Bainun, Ipoh, MYS.
Choroidal melanoma with ciliary body involvement is rare, especially in young adults and Asians. Here, we report the case of a young, healthy Chinese woman who complained of decreased vision in the left eye for one week. Her ocular examination and imaging were suggestive of choroidal melanoma involving the ciliary body.
View Article and Find Full Text PDFUveal melanoma incidence and survival analysis in Portugal between 2013 and 2022.
Cancer Epidemiol
June 2024
Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, Portugal; Clinical Academic Centre of Coimbra (CACC), Coimbra, Portugal.
Purpose: This study aims to provide a comprehensive overview of the clinical characteristics and epidemiology of uveal melanoma (UM) in the Portuguese population, evaluated at the National Reference Centre (NRC).
Methods: A prospective observational study was conducted, involving patients consecutively diagnosed with UM at the Portuguese NRC between July 2013 and December 2022. The study collected data on demographic and tumour characteristics, clinical staging according to the American Joint Committee on Cancer (AJCC), treatment approaches, local disease control, patient survival, and the occurrence of distant metastases.
Predictive model for iris melanoma.
Br J Ophthalmol
October 2024
Department of Quantitative Health Sciences & Taussig Cancer Institute, Cleveland Clinic Main Campus Hospital, Cleveland, Ohio, USA.
Article Synopsis
- A study aimed to create a predictive model for diagnosing iris melanoma by analyzing data from 100 confirmed cases of melanoma and 112 cases of iris naevus.
- Researchers collected patient demographics, clinical features, and tumor characteristics and used Lasso logistic regression for analysis.
- The model identified key indicators of melanoma, achieving an optimism-corrected AUC of 0.865, and suggested that a prediction calculator app could improve diagnosis and patient communication, with potential for further improvement using more data.
Massive ciliochoroidal melanoma masquerading as conjunctival melanoma.
Can J Ophthalmol
October 2024
Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 840 Walnut Street, 14th Floor, Philadelphia, PA.. Electronic address:
The Pediatric and Young Adult Choroidal and Ciliary Body Melanoma Genetic Study, A Survey by the European Ophthalmic Oncology Group.
Invest Ophthalmol Vis Sci
April 2024
Ocular Oncology Service, Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Purpose: To explore the genetic background of choroidal and ciliary body melanoma among children and young adults, with special focus on BAP1 germline variants in this age group.
Methods: Patients under the age of 25 and with confirmed choroidal or ciliary body melanoma were included in this retrospective, multicenter observational study. Nuclear BAP1 immunopositivity was used to evaluate the presence of functional BAP1 in the tumor.
Uveal melanoma in the Iranian population: two decades of patient management in a tertiary eye center.
Int J Retina Vitreous
March 2024
Ocular Oncology Service, Farabi Eye Hospital, Tehran University of Medical Sciences, South Kargar Street, Qazvin Square, Tehran, Iran.
Article Synopsis
- A study was conducted on 164 patients with uveal melanoma at a tertiary center in the Middle East to evaluate their characteristics and treatment outcomes.
- The majority of patients were treated using brachytherapy, with a 94% overall survival rate at five and eight years.
- The presence of distant metastasis was the only significant factor affecting overall survival, with most deaths occurring due to metastasis to the liver.