The first assessment of Angiotensin-Converting Enzyme 1 (ACE1) D/I polymorphism and demographic factors in association with COVID-19 outcomes in the Moroccan Population.

Background: SARS-CoV-2 responsible for the COVID-19 pandemic, infiltrates the human body by binding to the ACE2 receptor in the respiratory system cell membranes, leading to severe lung tissue damage. An analog of ACE2, ACE1, has gained attention due to its well-known Deletion/Insertion (D/I) polymorphism, which seems to be associated with COVID-19 outcomes. This study aims to reveal the allelic and genotypic frequencies of the rs4646994 polymorphism in the Moroccan population and investigate the association between COVID-19 outcomes and both genotypic and demographic data.

Chemical Composition and Assessment of the Anti-Inflammatory, Antioxidant, Cytotoxic and Skin Enzyme Inhibitory Activities of (L.) Osbeck Essential Oil and Its Major Compound Limonene.

Essential oils (EOs) from species have attracted attention for their diverse properties, including anti-inflammatory, antioxidant and cytotoxic effects, which address critical health challenges such as chronic diseases and skin disorders. (L.) Osbeck, which is a widely cultivated citrus fruit, is attracting increasing attention in the field of medicinal research due to its richness of limonene (comprising approximately 85-90% of the oil).

Computational insights into spin-polarized density functional theory applied to actinide-based perovskites XBkO₃ (X = Sr, Ra, Pb).

The exploration of perovskite compounds incorporating actinide and divalent elements reveals remarkable characteristics. Focusing on PbBkO, RaBkO, and SrBkO, these materials were studied using density functional theory (DFT) via the CASTEP code to analyze their electronic, optical, and mechanical properties. The results show semiconductor behavior, with respective band gaps of 1.

Challenges in Diagnosis and Treatment of Mandibular Florid Osseous Dysplasia: A Case Report.

Florid osseous dysplasia (FOD) is a rare, benign fibro-osseous lesion primarily involving the mandible and maxilla, with a higher prevalence in middle-aged women of African or Asian descent. This article presents a case of mandibular FOD complicated by secondary infection, emphasizing clinical presentation, diagnostic challenges, and treatment strategies. The unique radiographic features of FOD necessitate careful differential diagnosis to prevent misdiagnosis with other jaw lesions.

Chronic Kidney Disease of Unknown Etiology: A Global Health Threat in Rural Agricultural Communities-Prevalence, Suspected Causes, Mechanisms, and Prevention Strategies.

Chronic Kidney Disease of Unknown Etiology (CKDu) is a worldwide hidden health threat that is associated with progressive loss of kidney functions without showing any initial symptoms until reaching end-stage renal failure, eventually leading to death. It is a growing health problem in Asia, Central America, Africa, and the Middle East, with identified hotspots. CKDu disease mainly affects young men in rural farming communities, while its etiology is not related to hypertension, kidney stones, diabetes, or other known causes.

Newborn Screening for Six Primary Conditions in a Clinical Setting in Morocco.

Unlabelled: Newborn screening (NBS) represents an important public health measure for the early detection of specified disorders; such screening can prevent disability and death, not only from metabolic disorders but also from endocrine, hematologic, immune, and cardiac disorders. Screening for critical congenital conditions affecting newborns' health is a great challenge, especially in developing countries such as Morocco, where NBS program infrastructure is lacking. In addition, the consanguinity rate is high in Morocco.

Multimodal Machine Learning for Predicting Post-Surgery Quality of Life in Colorectal Cancer Patients.

Colorectal cancer is a major public health issue, causing significant morbidity and mortality worldwide. Treatment for colorectal cancer often has a significant impact on patients' quality of life, which can vary over time and across individuals. The application of artificial intelligence and machine learning techniques has great potential for optimizing patient outcomes by providing valuable insights.

Chemical Composition, Free Radicals and Pathogenic Microbes in the Extract Derived from : In Silico and In Vitro Approaches.

Marine algae are renowned for their health benefits due to the presence of functional bioactive compounds. In this context, this study aims to valorize the extract of a seaweed, (), through phytochemical characterization using liquid chromatography-mass spectrometry (HPLC-MS), as well as in vitro and in silico evaluation of its biological activities (antioxidant and antimicrobial). Phytochemical characterization revealed that the ethanolic extract of (DdEx) is rich in phenolic compounds, with a total of 22 phycocompounds identified.

Contribution of Hospital-Based Continuous Positive Airway Pressure (CPAP) Titration to the Treatment of Sleep Apnea Syndrome (SAS) Patients.

Objectives: This retrospective study aims to evaluate the efficacy of continuous positive airway pressure (CPAP) therapy in treating severe obstructive sleep apnea (OSA), based on polysomnographic parameters, and to highlight the importance of hospital-based titration in optimizing treatment and guiding choices of alternative ventilation modes.

Methods: Sixty-nine patients (n=69, 100%), predominantly female (n=49, 71%), were included in the study. Polysomnographic data were collected during hospital-based CPAP titration.

Crystal structure and Hirshfeld surface analyses, crystal voids, inter-molecular inter-action energies and energy frameworks of 3-benzyl-1-(3-bromoprop-yl)-5,5-di-phenyl-imidazolidine-2,4-dione.

The title mol-ecule, CHBrNO, adopts a cup shaped conformation with the distinctly ruffled imidazolidine ring as the base. In the crystal, weak C-H⋯O hydrogen bonds and C-H⋯π(ring) inter-actions form helical chains of mol-ecules extending along the -axis direction that are linked by additional weak C-H⋯π(ring) inter-actions across inversion centres. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from H⋯H (51.

Inhibitory potency of active metabolites from different polarities of Datura Stramonium seed extracts: GC-MS analysis, biological evaluations, and molecular docking studies.

Datura Stramonium is a well-known and important medicinal plant that is widely used in various medical systems to treat conditions such as asthma, diabetes, and inflammatory diseases. The aim of this study was to prepare extracts of D. stramonium seeds in different solvent polarities for assessing phytochemical potential, in vitro biological activities, and molecular docking studies.

Sub-chronic and acute toxicity of aqueous extracts subsp. (Maire) Figuerola to rodents.

Background: subsp. (Maire) Figuerola (SBm) is a plant endemic to Morocco and is one of the less studied species of Salvia. Herbal therapy is becoming more and more popular, especially in underdeveloped nations where access to medicinal herbs is affordable.

High-Performing Direct X-Ray Detection Made of One-Dimensional Perovskite-Like (TMHD)SbBr Single Crystal With Anisotropic Response.

3D and 2D organic hybrid perovskites, as well as double perovskites, have demonstrated their suitability for direct X-ray detection. However, the sensitivity and stability of 3D perovskite X-ray detectors are currently being hindered by the existing constraints on ion movement. Therefore, there is an immediate need to develop X-ray detectors that are both highly sensitive and stable while also being environmentally friendly.

Soil health in Moroccan olive agroecosystems: The bioindication role of terrestrial nematode dynamics.

Terrestrial nematodes are important soil microorganisms that modulate biological processes in soil ecosystems. Thus, these microorganisms have strong potential as soil health bioindicators. This study aimed to investigate their distribution patterns in Moroccan olive agroecosystems and to evaluate their structural and functional dynamics shaping soil disturbance status.

Food safety knowledge, attitudes, and practices among food handlers in collective catering in central Morocco.

Food safety is a significant challenge for countries worldwide due to the growing number of food poisoning outbreaks, particularly in the catering sector, which impacts consumer health and imposes additional economic costs on countries. The role of food handlers in restaurants is crucial for guaranteeing this safety and protecting the health of citizens. This pioneering study in central Morocco aimed to assess food safety knowledge, attitudes, and practices (KAPs) among food handlers and to identify key factors influencing adequate knowledge, positive attitudes, and effective practices.

Lignin-Furanic Rigid Foams: Enhanced Methylene Blue Removal Capacity, Recyclability, and Flame Retardancy.

Worldwide, populations face issues related to water and energy consumption. Water scarcity has intensified globally, particularly in arid and semiarid regions. Projections indicate that by 2030, global water demand will rise by 50%, leading to critical shortages, further intensified by the impacts of climate change.

Green Synthesis of Zinc Oxide Nanoparticles for Tetracycline Adsorption: Experimental Insights and DFT Study.

An eco-friendly approach was used to fabricate zinc oxide nanoparticles (ZnO NPs) using thyme, L., leaf extract. The produced ZnO nanoparticles were characterized by XRD and SEM analysis.

Therapeutic patient education: Impact on lung function in Moroccan adult asthma patients?

Background: Despite the availability of effective asthma medications, the condition remains poorly controlled, making it one of the most common emergency room and physician visits each year. Appropriate asthma education programs are needed to maintain or improve optimal lung function in asthmatics. This study aimed to evaluate changes in lung function parameters in adult asthmatics before and after a structured educational intervention.

Crystal structure and piezoelectric properties of 0.79(NaBi)TiO-0.05BaTiO-0.16(KBi)TiO ceramics prepared by solid-state method.

The solid-state reaction technique was employed to synthesize lead-free ceramics, specifically (1-x-y)(NaBi)TiO-xBaTiO-y(KBi)TiO. For attaining a pure perovskite phase, it was found that the optimal calcination temperature is 1000 °C, maintained for a duration of 4 h. Through X-ray diffraction (XRD) analysis, the morphotropic phase boundary (MPB) was detected in (1-x-y)NBT-xBT-yKBT ceramics for certain molar compositions, specifically in 0.

Antioxidant potential, antimicrobial activity, polyphenol profile analysis, and cytotoxicity against breast cancer cell lines of hydro-ethanolic extracts of leaves of ( L.) from Eastern Morocco.

Introduction: Many beneficial compounds found in fig leaves can be used in tea and medicine. These compounds aid with digestion, reduce inflammation, and treat diabetes and bronchitis. Chetoui, Malha, Ghoudane, and Onk Hmam fig leaf hydro-ethanol extracts from Eastern Morocco were analyzed for metabolites and biological activities.

Turning trash into treasure: Exploring the potential of AI in municipal waste management - An in-depth review and future prospects.

Rapid urbanization, economic expansion, and population growth have increased waste generation in many nations worldwide. Research on municipal waste management (MWM) is moving towards new frontiers in efficiency and applicability due to the growing amount of data being collected in these systems and the convergence of various technological applications; artificial intelligence (AI) techniques present novel and creative alternatives for MWM. Even though much research has been conducted in this field, relatively few review studies assess how advancements in AI techniques can contribute to the sustainable advancement of MWM systems.

Assessment and mapping of water erosion by the integration of Gavrilovic's "EPM" model in the MENA region: case study of the Admer-Ezem sub-watershed, upper Oum-Rbaa basin, Morocco.

The main goal of the research is to assess soil erosion while analyzing the spatial distribution of its evolution using the EPM (erosion potential model). Situated northwest of the upper Oum-Rbaa watershed in Morocco, the Admer-Ezem watershed is part of the research area. Its climate is Mediterranean, ranging from semi-arid to subhumid bioclimate, which favors fairly scattered vegetation and poor soil.

A comprehensive review of β-cyclodextrin polymer nanocomposites exploration for heavy metal removal from wastewater.

This review focuses on the application of β-cyclodextrin (β-CD) polymer nanocomposites (NCs) in the heavy metals (HMs) removal from contaminated water sources. This manuscript's originality consists of an in-depth analysis of recent advances in using β-cyclodextrin nanocomposites (β-CD-NCs) to remove HMs from wastewater, highlighting literature gaps, innovations, and challenges in this field, suggesting perspectives on existing theories, and outlining implications for future research directions. Combining nanoparticles with the β-CD polymer yields stable, reusable β-CD-NCs that are effective and efficient in HM adsorption.

Description of Mesophylax isly sp. nov. (Trichoptera, Limnephilidae) from Morocco, and new genus records from the Balkans.

The male and female genitalia of Mesophylax isly Ibrahimi, Taybi & Mabrouki sp. nov. (Limnephilidae) are described based on material collected from the Isly River in Morocco.