The Influence of GBA and LRRK2 on Mood Disorders in Parkinson's Disease.

Background: Mood disorders have emerged as major non-motor comorbidities in Parkinson's disease (PD) even at the prodromal stage of the disease. Mutations in the and genes are common among Ashkenazi Jews, with more severe phenotype reported for -PD.

Objective: To explore the association between genetic status and mood related disorders before and after diagnosis of PD and the association between mood-related medications, phenotype, and genetic status.

Early Use of Echocardiography in Patients With Acute Pulmonary Embolism: Findings From the RIETE Registry.

Background Transthoracic echocardiography ( TTE ) is often considered for risk stratification of patients with acute pulmonary embolism ( PE ). We sought to determine the contemporary utilization of early TTE (within 72 hours of PE diagnosis) and explored the association between TTE findings and PE -related mortality. Methods and Results Data from the RIETE (Registro Informatizado Enfermedad TromboEmbolica) registry, a multicenter registry of consecutive patients with acute PE , were used (2001-July 2017).

Long-Term Safety of In Utero Exposure to Anti-TNFα Drugs for the Treatment of Inflammatory Bowel Disease: Results from the Multicenter European TEDDY Study.

Objectives: The long-term safety of exposure to anti-tumor necrosis factor (anti-TNFα) drugs during pregnancy has received little attention. We aimed to compare the relative risk of severe infections in children of mothers with inflammatory bowel disease (IBD) who were exposed to anti-TNFα drugs in utero with that of children who were not exposed to the drugs.

Methods: Retrospective multicenter cohort study.

A phase 1/2a, dose-escalation, safety, pharmacokinetic, and preliminary efficacy study of intraperitoneal administration of BC-819 (H19-DTA) in subjects with recurrent ovarian/peritoneal cancer.

Background: H19 is a paternally imprinted, oncofetal gene expressed in various embryonic tissues and in 85% of the ovarian tumors. H19-DTA (BC-819) is a DNA plasmid that drives the expression of the diphtheria toxin gene under the regulation of the H19 promoter sequence and therefore is a potential treatment for various tumors that overexpress the H19 gene, among them-ovarian cancer.

Objective: To assess the safety and efficacy of intra-peritoneal (IP) instillations of H19-DTA (BC-819) plasmid in treating ovarian/peritoneal cancer patients with advanced recurrent disease.

A prospective, randomized, three arm, open label study comparing the safety and efficacy of PP110, a novel treatment for hemorrhoids to preparation-H® maximum strength cream in the treatment of grade 2-3 hemorrhoids.

Background: Hemorrhoids are a common disorder that affects the quality of life of millions of people worldwide. The effectiveness of OTC medication is limited and they mainly provide symptomatic relief. In order to treat this ailment, we formulated PP110 Gel and Wipes, as a novel treatment for hemorrhoids.

[Perspectives in future asthma therapy].

Five to ten percent of all asthmatics, many dozens of millions of patients all over the world, do not respond to maximal medical therapy, including systemic steroids, and the toll of treating them constitutes about eighty percent of the total cost of managing all asthmatics. Other asthmatics who do respond to medical therapy either are not compliant with their medications or suffer from disabling adverse effects. The future therapy of asthma will concentrate on finding medical solutions to these sub-groups of patients but the entire asthmatic population will enjoy its achievements.

Patients with occupational contact dermatitis in Israel: quality of life and social implications.

One of the most common occupational diseases is skin disease caused as a result of contact with work-related materials or exacerbated by them. Although occupational-related skin disease is a common condition, it is not considered to be a serious one and, therefore, has not received satisfactory attention in the psycho-social literature or in the social work profession. In our study, 70 occupational contact dermatitis (OCD) patients were interviewed by telephone regarding psychological, social, economic, and subjective issues related to the disease.

Postoperative chylous ascites--the urologist's view.

Postoperative chylous ascites is a rare complication of retroperitoneal surgery caused by incidental disruption of major retroperitoneal lymphatics and is associated with serious mechanical, nutritional and immunological consequences due to the constant loss of protein and lymphocytes. Different management schemes may be used successfully to treat chylous ascites. Treatment should be adjusted to the severity of the lymphatic leak and its consequences.

[Cognitive assessment in geriatric rehabilitation].

Geriatric rehabilitation is a prolonged and expensive process. There is a need to evaluate the rehabilitation potential because of the increasing number of elderly in the population and limited resources. Cognition is one of the components of occupational performance and its evaluation is a crucial part of comprehensive geriatric assessment.

Comparative genomic hybridization in polycythemia vera and essential thrombocytosis patients.

Polycythemia vera (PV) and essential thrombocytosis (ET) are clonal chronic myeloproliferative disorders originating from a multipotent stem cell. Bone marrow examinations reveal chromosomal abnormalities in 15-43% of PV patients and 5% of ET patients, but no specific recurring abnormality has been found to date. We aimed to find cytogenetic aberrations in PV and ET by comparative genomic hybridization (CGH), a relatively new molecular cytogenetic technique.

Association between alopecia and response to aggressive chemotherapy in patients with Hodgkin's disease.

The clinical significance and implications of absence of alopecia and/or neutropenia in patients treated with chemotherapy for malignant disease is unknown. We hypothesized that there is a common mechanism of resistance to the effects and the adverse effects of anticancer treatment, which may have clinical implications. To evaluate this hypothesis, we conducted a retrospective analysis of the charts of 17 consecutive patients with Hodgkin's disease who received at least 4 courses of combination chemotherapy (ABVD or MOPP/ABV).

Interleukin-6 and interleukin-6 receptor secretion by chronic lymphatic leukaemia and normal B lymphocytes: effect of PMA and PWM.

Interleukin-6 (IL-6) and soluble interleukin-6 receptor (sIL-6R) were detected in supernatants of cultures of B chronic lymphatic leukaemia (CLL) lymphocytes. Phorbol-12-myristate 13 acetate (PMA) caused a decrease in the levels of IL-6 in 14 out of 16 cultures and an increase in levels of sIL6R in all 15 cases. The effect of pokeweed mitogen (PWM) was variable and not significant.

Transforming growth factor-beta prevents stem cell factor-mediated rescue of mast cells from apoptosis after IL-3 deprivation.

IL-3-dependent mast cells undergo apoptosis upon removal of IL-3, an event that is prevented by the addition of stem cell factor (SCF) acting through its receptor c-kit, suggesting that SCF provides a mechanism to allow mast cells to survive and to differentiate in tissues in the relative absence of IL-3. This observation is consistent with the thesis that the microenvironment, in part, controls mast cell number and viability by modulating SCF production and release. The purpose of the present study was to determine whether a second factor, TGF-beta 1, was capable of modifying the SCF-mediated survival pathway.

Non-Hodgkin's lymphoma and pregnancy.

Non-Hodgkin's lymphoma (NHL) is infrequently diagnosed during pregnancy. Most NHL's complicating pregnancy are aggressive and disseminated. This presentation together with the possible teratogenecity of diagnostic methods dictate a limited staging workup during pregnancy.

Detection of bcl rearrangements in B-CLL by fluorescence in situ hybridization.

Data concerning oncogene activation in CLL are very limited. When studied by Southern blot, rearrangements of bcl-1, bcl-2, and bcl-3 have been only infrequently reported. We evaluated the role of fluorescence in situ hybridization (FISH) in the detection of gene rearrangements in two CLL patients.

The response of diffuse large cell and other intermediate grade non-Hodgkin's lymphomas to adriamycin containing combination chemotherapy.

Adriamycin containing combination chemotherapy (ACCC) is usually delivered to patients with stages III, IV diffuse large cell (DLCL) non-Hodgkin's lymphoma (NHL). Although this mode of therapy is also commonly used in other intermediate grade lymphomas, it's role in the latter subset of patients is not well defined. In a retrospective analysis we evaluated and compared the outcome of previously untreated DLCL and non-DLCL intermediate grade lymphoma patients who received as initial therapy, "first generation" ACCC.

A new liver and soft tissue biopsy instrument.

A new liver biopsy instrument taking the form of a suction biopsy syringe with two pistons and a Menghini needle, is described. A vacuum is first created, and the whole procedure is effected by a continuous uninterrupted movement into the liver and instantaneous withdrawal. The syringe is held in one hand.

Intrathecal vancomycin in the treatment of Ommaya reservoir infection by Staphylococcus epidermidis.

Ommaya reservoirs are frequently used in the treatment of patients with meningeal involvement by malignant diseases. The reported infectious complications range between 5-50%. We describe a 35-year-old male patient with Staphylococcus epidermidis infection of an Ommaya reservoir in whom intravenous antibiotics and removal of the reservoir failed to eradicate the organism.

Ofloxacin and the gastrointestinal tract: a potential role in the treatment of bacterial enteritis.

Ofloxacin is highly active against most pathogens causing bacterial enteritis. High faecal levels are achieved readily following a single oral dose and may persist for up to five days despite partial binding by faeces. In addition, adequate ofloxacin levels persist in pancreatic secretions and bile for 12 to 14 h following oral administration.

The AR-8800--a new impedance pneumograph (plethysmograph) respiratory monitor.

The Atlas AR-8800, an impedance pneumograph respiratory monitor, is claimed to detect both apnea and hypoventilation. The authors tested the monitor on eight anesthetized patients and found the apnea alarm to be effective and efficient. In addition, the ventilation alarm index, a system specific to this monitor, detected hypoventilation and also differentiated between irrelevant body movements and apnea.