Muscle stiffness of the rectus femoris and vastus lateralis in children with Osgood-Schlatter disease.

Background: The relevance of the mechanical properties of muscles in relation to Osgood-Schlatter disease (OSD) remains unclear. The present study aimed to examine rectus femoris (RF) and vastus lateralis (VL) muscle stiffness in children with OSD.

Methods: A total of 28 legs affected by OSD and 26 legs without OSD were assessed.

Small business under the COVID-19 crisis: Expected short- and medium-run effects of anti-contagion and economic policies.

This study makes a causal inference on the effects of anti-contagion and economic policies on small business by conducting a survey on Japanese small business managers' expectations about the pandemic, policies, and firm performance. We first find the business suspension request decreased targeted firms' sales by 10 percentage points on top of the baseline 9 percentage points decline due to COVID-19, even though the Japanese anti-contagion policy was in a form of the government's request that is not legally enforceable. Second, using a discontinuity in the eligibility criteria, we find lump-sum and prompt subsidies improved firms' prospects of survival by 19 percentage points.

Cooperative interactions among females can lead to even more extraordinary sex ratios.

Hamilton's local mate competition theory provided an explanation for extraordinary female-biased sex ratios in a range of organisms. When mating takes place locally, in structured populations, a female-biased sex ratio is favored to reduce competition between related males, and to provide more mates for males. However, there are a number of wasp species in which the sex ratios appear to more female biased than predicted by Hamilton's theory.

Eccentric exercise causes delayed sensory nerve conduction velocity but no repeated bout effect in the flexor pollicis brevis muscles.

Purpose: This study was aimed at investigating the effect of eccentric contractions (ECCs) of flexor pollicis brevis muscles (FPBMs) on motor and sensory nerve functions as well as the ipsilateral repeated bout effect (IL-RBE) and contralateral (CL)-RBE of motor and sensory nerve conduction velocities following ECCs.

Methods: Thirty-two young healthy men (age: 19.6 ± 0.

[Factors associated with behaviors to prevent COVID-19 infection during the declaration of emergency: A study among Tokyo residents].

Objectives　The COVID-19 pandemic spread rapidly across the globe during the first half of 2020. In Japan, a state of emergency was declared on April 7, 2020, which had a significant impact on the life of citizens. This study focused on behaviors like avoiding going out or coming in contact with others and frequent hand-washing to prevent the infection and the spread of COVID-19 among people living in Tokyo.

Force-velocity relationship profile of elbow flexors in male gymnasts.

Background: The theoretical maximum force (F), velocity (V), and power (P) of athletes calculated from the relationship between force and velocity (F-V relationship) and the slope of the F-V relationship, reflect their competitive and training activity profiles. Evaluating the F-V relationship of athletes facilitates categorizing the profiles of dynamic muscle functions in relation to long-term sport-specific training. For gymnastics, however, no studies have tried to examine the profiles of F-V relation and power output for upper limb muscles in relation to the muscularity, while the use of the upper extremities in this sport is very unique as described earlier.

Fucoidan Ameliorates Renal Injury-Related Calcium-Phosphorus Metabolic Disorder and Bone Abnormality in the CKD-MBD Model Rats by Targeting FGF23-Klotho Signaling Axis.

Recently, chronic kidney disease (CKD)-mineral and bone disorder (MBD) has become one of common complications occurring in CKD patients. Therefore, development of a new treatment for CKD-MBD is very important in the clinic. In China, Fucoidan (FPS), a natural compound of has been frequently used to improve renal dysfunction in CKD.

4-week eicosapentaenoic acid-rich fish oil supplementation partially protects muscular damage following eccentric contractions.

Background: We previously showed 8-week of fish oil supplementation attenuated muscle damage. However, the effect of a shorter period of fish oil supplementation is unclear. The present study investigated the effect of fish oil, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), for 4 weeks on muscular damage caused by eccentric contractions (ECCs) of the elbow flexors.

Plasma Eicosapentaenoic Acid Is Associated with Muscle Strength and Muscle Damage after Strenuous Exercise.

Background: Although the ingestion of total omega-3 fatty acids (omega-3) is positively related with muscular strength in older persons, little is known about the effect of omega-3 plasma levels on muscular function before and after exercise in young men. Moreover, omega-3 supplementation has a positive role in exercise-induced acute muscle damage. This study investigated the relationship between plasma omega-3 in the blood and promotion and preservation of muscle strength after eccentric contractions (ECCs) in young men.

Fast-Velocity Eccentric Cycling Exercise Causes Greater Muscle Damage Than Slow Eccentric Cycling.

This study aims to investigate muscle damage occurring in the early and recovery phases after fast-velocity and slow-velocity eccentric cycling. Eleven untrained men (age, 20.0 ± 1.

Reliability and validity of a short Japanese version of the UPPS-P Impulsive Behavior Scale.

Objective: This study aimed to verify the reliability and validity of a Japanese version of the S-UPPS-P Impulsive Behavior Scale. This is expected to facilitate comparisons of findings between international and Japanese samples in studies of impulsivity.

Methods: Two surveys were conducted.

Greater thermoregulatory strain in the morning than late afternoon during judo training in the heat of summer.

Purpose: The time-of-day variations in environmental heat stress have been known to affect thermoregulatory responses and the risk of exertional heat-related illness during outdoor exercise in the heat. However, such effect and risk are still needed to be examined during indoor sports/exercises. The current study investigated the diurnal relationships between thermoregulatory strain and environmental heat stress during regular judo training in a judo training facility without air conditioning on a clear day in the heat of summer.

Total Flavones of Remodels Gut Microbiota and Inhibits Microinflammation in Chronic Renal Failure Progression by Targeting Autophagy-Mediated Macrophage Polarization.

Background: Recently, progression of chronic renal failure (CRF) has been closely associated with gut microbiota dysbiosis and intestinal metabolite-derived microinflammation. In China, total flavones of (TFA), a component of , has been widely used to delay CRF progression in clinics for the past two decades. However, the overall therapeutic mechanisms remain obscure.

Antecedents and Outcomes of Enrichment Among Working Family Caregivers of People With Dementia: A Longitudinal Analysis.

Objectives: Despite evidence of negative aspects of the work-caregiving interface (e.g., work-family conflict) among family caregivers of people with dementia (PWD), little is known about the positive aspects (e.

Do eye movements enhance visual memory retrieval?

When remembering an object at a given location, participants tend to return their gaze to that location even after the object has disappeared, known as Looking-at-Nothing (LAN). However, it is unclear whether LAN is associated with better memory performance. Previous studies reporting beneficial effects of LAN have often not systematically manipulated or assessed eye movements.

Muscular endurance and muscle metabolic responses to 8 weeks of omega-3 polyunsaturated fatty acids supplementation.

Background: It has been well known that exercise training improves muscular endurance; however, whether nutritional strategies can be used to enhance muscular endurance remains unclear. Herein, we tested the hypothesis that 8 weeks of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation, known to promote oxygen availability and lipid metabolism, would attenuate muscular fatigue caused by numerous muscle contractions.

Methods: Nineteen healthy men were randomly assigned to a placebo group (n = 9) and fish oil group (n = 10) in a double-blind fashion.

Maintenance of endothelial function following acute resistance exercise in females is associated with a tempered blood pressure response.

Acute resistance exercise-induced hypertensive stimulus impairs endothelial function in males. Because prior work indicates that female subjects have a tempered blood pressure response to acute resistance exercise, we hypothesized that, compared with males, females would better maintain endothelial function following resistance exercise and that this preservation would be associated with a lower hypertensive stimulus. Twenty-nine young healthy males ( = 16) and females ( = 13) participated in this study.

Innovative approach to adolescent mental health in Japan: School-based education about mental health literacy.

Aims: Improving mental health literacy through school-based education may encourage mental health promotion, prevention and care and reduce stigma in adolescents. In Japan, instruction about mental illness has been formulated in a Course of Study that reflects governmental curriculum guidelines, which will be enforced from 2022 to promote an understanding of current issues of adolescent health. Educational resources available to schoolteachers have been developed.

[Triptolide inhibits NLRP3 inflammasome activation and ameliorates podocyte epithelial-mesenchymal transition induced by high glucose].

The aim of this paper was to explore the effects of triptolide( TP),the effective component of Tripterygium wilfordii on improving podocyte epithelial-mesenchymal transition( EMT) induced by high glucose( HG),based on the regulative mechanisms of Nod-like receptor protein 3( NLRP 3) inflammasome in the kidney of diabetic kidney disease( DKD). The immortalized podocytes of mice in vitro were divided into the normal( N) group,the HG( HG) group,the low dose of TP( L-TP) group,the high dose of TP( HTP) group and the mannitol( MNT) group,and treated by the different measures,respectively. More specifically,the podocytes in each group were separately treated by D-glucose( DG,5 mmol·L~(-1)) or HG( 30 mmol·L~(-1)) or HG( 30 mmol·L~(-1)) + TP( 5 μg·L~(-1))or HG( 30 mmol·L~(-1)) + TP( 10 μg·L~(-1)) or DG( 5 mmol·L~(-1)) + MNT( 24.

Pilot study of a basic individualized cognitive behavioral therapy program for chronic pain in Japan.

Background: Chronic pain is a major health problem, and cognitive behavioral therapy (CBT) is its recommended treatment; however, efforts to develop CBT programs for chronic pain and assess their feasibility are remarkably delayed in Asia. Therefore, we conducted this pilot study to develop a basic individualized CBT for chronic pain (CBT-CP) and assessed its feasibility for use in Japan.

Methods: Our study was an open-labeled before-after trial without a control group conducted cooperatively in five Japanese tertiary care hospitals.

[Molecular mechanisms of non-coding RNA regulating autophagy and interventional effects of Chinese herbal medicine].

Long non-coding RNAs(lncRNAs) and microRNAs(miRNAs),as members of the non-coding RNA family,play important roles in upstream processes that regulate autophagy in mammalian cells. LncRNA and miRNA participate in various phases of the process of autophagy,including initiation,vesicle nucleation,autophagosome maturation and autophagosome fusion. Some non-coding RNAs exert bidirectional regulatory functions in the process of autophagy,include the maternally expressed gene 3(MEG3),H19 and miR-21,whereas others either inhibit autophagy(including GAS5,miR-34 a and miR-30 a) or promote autophagy(including MALAT1,miR-152 and miR-24).

Selective Sugar Recognition by Anthracene-Type Boronic Acid Fluorophore/Cyclodextrin Supramolecular Complex Under Physiological pH Condition.

We synthesized novel PET (photoinduced electron transfer)-type fluorescence glucose probe [(4-(anthracen-2-yl-carbamoyl)-3-fluorophenyl)boronic acid], which has a phenylboronic acid (PBA) moiety as the recognition site and anthracene as the fluorescent part. Although the PBA derivatives dissociate and bind with sugar in the basic condition, our new fluorescent probe can recognize sugars in the physiological pH by introducing an electron-withdrawing fluorine group into the PBA moiety. As a result, the p value of this fluorescent probe was lowered and the probe was able to recognize sugars at the physiological pH of 7.