A 3D printed hydrostatic skeleton for an earthworm-inspired soft burrowing robot.

Moving through soil is challenging for robots, particularly for soft robots. Herein, we propose a support structure, based on the hydrostatic skeleton of earthworms, to overcome this problem. To create extremely flexible, thin-walled, worm-sized deformed segments, a specialized 3D printer for low-hardness rubber was utilized.

Genetically engineered pigs manifesting pancreatic agenesis with severe diabetes.

Introduction: Pancreatic duodenum homeobox 1 () expression is crucial for pancreatic organogenesis and is a key regulator of insulin gene expression. Hairy and enhancer of split 1 () controls tissue morphogenesis by maintaining undifferentiated cells. encodes a basic helix loop helix (bHLH) transcriptional repressor and functionally antagonizes positive bHLH genes, such as the endocrine determination gene neurogenin-3.