Caffeine use in preterm neonates: national insights into Turkish NICU practices.

Objective: Caffeine is a proven medication used for the prevention and treatment of apnea in premature infants, offering both short- and long-term benefits. International guidelines provide a range of recommendations regarding the preterm population eligible for caffeine prophylaxis, including the timing, dosage, and duration of treatment. Our national guidelines, published prior to the most recent updates of the international guidelines, recommend the use of caffeine citrate starting from the first day after delivery for preterm infants with a gestational age of <28 weeks.

Determining the Psychometric Properties of the Turkish Version of the Positive Caregiving Experience Scale in Dementia.

Background: Caring for individuals with dementia presents significant challenges for caregivers. However, positive experiences such as personal growth and emotional satisfaction play a vital role in fostering resilience and improving caregiving outcomes. This study highlights the need for a culturally relevant tool to assess these positive feelings, focusing on the adaptation and validation of the Dementia Caregiver Positive Feeling Scale for Turkish caregivers.

Demographic variation in continuous glucose monitoring utilisation among patients with type 1 diabetes from a US regional academic medical centre: a retrospective cohort study, 2018-2021.

Objective: While continuous glucose monitoring (CGM) utilisation has been increasing among patients with type 1 diabetes (T1D), few studies have examined patterns of use across age, race/ethnicity and insurance status together. In this study, we examine CGM utilisation among patients with T1D from a regional academic medical centre across all insurance types.

Design And Setting: This is a retrospective cohort study including both paediatric and adult patients with T1D who visited a regional academic medical centre between 1 January 2018 and 31 December 2021.

The influence of Pitanguy ligament on the supra tip break point in open rhinoplasty.

Background: The supratip break point is paramount in nasal aesthetics. "Polly beak deformity" denotes a swollen supratip, posing aesthetic concerns. The Pitanguy ligament facilitates tissue attachment and aids in the control of fibrosis.

The Comparative Evaluation of Depression, Life Satisfaction, and Quality of Life Between Female Patients with Lipedema and Lymphedema.

Lymphedema and lipedema are chronic conditions significantly impacting psychosocial status and quality of life (QOL). However, comparative studies on depression, life satisfaction, functional status, and QoL in these conditions are lacking. This study aims to fill this gap by providing a comparative evaluation of functional status, depression, life satisfaction, and QoL in patients with lymphedema and lipedema.

An ex vivo experimental study comparing the effects of the holmium: yttrium-aluminum-garnet and thulium fiber lasers on testicular tissue.

The effects of lasers on testicular tissue have not yet been investigated in detail. In this experimental ex vivo study, we aimed to demonstrate and compare the effects of the holmium:yttrium-aluminum-garnet (Ho:YAG) and thulium fiber laser (TFL) lasers on testicular tissue. An ex vivo experiment was performed using calf testes.

Investigation of the Relationship Between Weaning Readiness and Maternal Depression: Cross-Sectional Online Survey.

: The initiation and continuation of breastfeeding are just as crucial as its conclusion. This study aimed to explore the connection between maternal depression and readiness for weaning. Although previous studies have examined maternal depression in the context of breastfeeding initiation and continuation, limited research has explored its role in weaning readiness.

Nutritional Status Is Associated with Mortality but Not Appropriate Discharge of Implantable Cardioverter Defibrillators in Patients with Heart Failure.

To investigate the predictive value of nutritional status in heart failure (HF) patients with an implantable cardioverter defibrillator (ICD), and to identify factors associated with ICD discharge and mortality. This retrospective study was conducted by analyzing data from 2017 to 2021. HF patients who underwent ICD implantation for primary prevention were included.

Atrial and ventricular strain changes after transcatheter pulmonary valve replacement in patients with repaired tetralogy of Fallot: a feature tracking cardiac MRI study.

Purpose: In patients with repaired tetralogy of Fallot, transcatheter or surgical pulmonary valve replacement is recommended. However, it is not clear whether pulmonary valve replacement preserves systolic and diastolic functions of both ventricles. The aim of the study is to investigate the impact of transcatheter pulmonary valve replacement on atrial and ventricular myocardial strain changes by feature-tracking cardiac magnetic resonance imaging.

Short- and Medium-Term effects of major Ozone therapy on disease parameters in fibromyalgia syndrome: A retrospective study.

Background: Fibromyalgia syndrome (FMS) is a chronic condition causing widespread pain, fatigue, and sleep disturbances. Conventional treatments often provide limited relief, leading to growing interest in complementary therapies like ozone therapy.

Objective: This study aims to retrospectively evaluate the short- and medium-term efficacy of ozone therapy in patients with FMS, focusing on changes in pain, functional status, sleep quality, fatigue, anxiety, and depression.

Impact of interactive ethics education program on nurses' moral sensitivity.

BackgroundNurses working in a clinic must be morally sensitive to identify unethical circumstances and act morally. Educational strategies that can effectively gain this sensitivity are a matter of curiosity.ObjectiveThis study aimed to examine if an interactive ethics training program would benefit (a) moral sensitivity and (b) knowledge.

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Identification of Nursing-Sensitive Indicators on Pressure Injuries/Ulcers: A Systematic Review.

This systematic review aims to develop a conceptual framework to identify nursing-sensitive indicators for preventing and managing pressure ulcers. The first step involves defining evidence-based indicators critical to effective prevention and management. The second step examines the relationships influencing the management of these indicators, using insights derived from scientific research findings.

Evaluation of the relationship of the sigmoid sinus with the facial nerve and semicircular canals in terms of mastoid surgery.

Purpose: The location of the sigmoid sinus may change according to the ventilation status of the mastoid bone, in which case the relationship of the sigmoid sinus to the facial nerve and semicircular canals is predicted to change. The purpose of this study was to evaluate the importance of sigmoid sinus distances to the facial nerve and semicircular canals concerning mastoid surgery.

Methods: The relationship of the sigmoid sinus and the facial nerve with the semicircular canals was analyzed from the cone beam computed tomography images of 75 male and 95 female subjects, aged 18-65 years.

Impact of Otoplasty on Speech Intelligibility and Auditory Function in Noise.

Prominent ear deformity, affecting up to 5% of the white population, is characterized by an absent antihelical fold and conchal cartilage hypertrophy. These anatomical changes can potentially alter auditory function, including speech intelligibility in noise. To evaluate changes in auditory function, particularly speech intelligibility in noise, following otoplasty for prominent ear deformities.

Evaluation of the effect of different diets applied to breastfeeding mothers on the composition and quantity of human milk.

Introduction: This study aimed to elucidate the relationship between maternal nutrition and the quantity and composition of breast milk.

Methods: All mothers were administered sequentially, with each lasting one week, a healthy nutrition diet, a carbohydrate-rich diet, and a protein-rich diet.

Results: Compared to the healthy nutrition diet, a statistically significant increase was observed in the levels of glutamic acid, serine, glycine, histidine, tyrosine, valine, isoleucine, leucine, and lysine in milk following the carbohydrate-rich diet (p < 0.

Predictive value of homocysteine levels in embryo culture media for embryo selection in infertile patients with endometriosis.

Objective: To investigate the possible ability of homocysteine (Hcy) levels in embryo culture media for estimating better invitro fertilization outcomes in endometriosis patients.

Materials And Methods: Nineteen women with endometriosis who were admitted to Cerrahpaşa Medical Faculty, Department of Obstetrics and Gynecology, Infertility Outpatient Clinic with the diagnosis of infertility were included in the study. The results of intracytoplasmic sperm injection treatments were recorded and Hcy levels in the embryo culture were evaluated.

Enhanced Bioaccessibility and Anticancer Activity of Brazilian Propolis Extracted with L-Lactic Acid.

This study aimed to investigate whether L-lactic acid (LA), as a better solvent than ethanol (EtOH), enhances the bioaccessibility of phenolic compounds in red and green Brazilian propolis and to evaluate their potential anticancer effects . gastrointestinal digestion was performed by sequentially subjecting propolis extracts to buccal, gastric, and intestinal digestion phases, and samples were collected at each stage for analysis. The total phenolic content (TPC) was determined using the Folin-Ciocalteu reagent with gallic acid as a standard.

Apicoectomy versus apical curettage in combination with or without L-PRF application: a randomized clinical trial.

This study compared the efficacy of apicoectomy and apical curettage with and without leukocyte- and platelet-rich fibrin (L-PRF) in treating large periapical lesions. Sixty-four adults (30 male, 34 female) with a previously endodontically treated tooth and a large periapical lesion were randomized into four groups (n = 16): retrograde obturation (RG), orthograde obturation (OG), RG + L-PRF, and OG + L-PRF. All participants underwent root canal retreatment in two sessions.

Enhanced In Vitro and In Vivo Autophagy Suppression via LC3 siRNA-Loaded "Smart" Nanoparticles and Doxorubicin Combination Therapy in Triple Negative Breast Cancer.

Autophagy plays a complex role in cancer progression, serving as both a tumor suppressor and a promoter, depending on the context. In triple-negative breast cancer (TNBC), a particularly aggressive subtype with limited therapeutic options, autophagy inhibition has emerged as a promising strategy to enhance the efficacy of chemotherapy. This study investigates the synergistic effects of autophagy suppression using LC3 siRNA-loaded "smart" nanoparticles (LC3siRNA-NPs) in combination with doxorubicin (DOX) to overcome chemoresistance in TNBC.

Investigation of the Potential Effect of Complement 5 on Transplantation Outcome by Bioinformatics Tools.

Introduction: Activation of the complement system following transplantation may result in allograft rejection. Our study aimed to evaluate the potential relationship between factors affecting kidney transplant success and complement 5 (C5) using bioinformatic tools.

Methods: GenCards and Genemania were used to provide the genetic functional information belonging to the C5 gene, and genomic browsers of STRING, UCSC, KEGG were used to reveal interactions with other genes and various pathways.

Computational insights into the allosteric behavior of mini proinsulin driven by C peptide mobility.

The production of recombinant insulin remains challenging, particularly in enhancing refolding efficiency and bioactivity. Mini-proinsulin analogs, which involve reducing the length of the C-peptide, offer potential improvements in insulin production. This study aims to evaluate mini-proinsulin analogs' design and receptor binding dynamics to optimize recombinant insulin production in E.

Effects of dietary gluten on body weight and gut microbiota in BALB-C mice using 16 S rRNA-Based analysis.

Despite the widespread adoption of gluten-free diets for weight management, the relationship between gluten intake and obesity remains unclear because of the limited number of controlled studies available in the literature. Furthermore, there is ongoing debate regarding the impact of gluten-containing diets on the gut microbiota. This study aimed to investigate the effects of gluten consumption on the body weight and intestinal microbiota of mice fed a high-fat diet.

Radiological outcomes of two non-surgical management methods for mid-shaft clavicle fractures in school-age children: No difference between figure-of-eight bandage and arm sling.

Background: Although non-surgical management is a commonly used treatment for pediatric clavicle fractures, there is limited data in the literature regarding the most effective method. This study aims to compare the radiological outcomes of the figure-of-eight bandage versus the arm sling in the treatment of mid-shaft clavicle fractures in school-age children.

Methods: Patients were divided into two groups based on the preferred conservative management method: Group 1 (arm sling) and Group 2 (figure-of-eight bandage).

A Wide QRS Complex Tachycardia with Variation of Ventriculoatrial Interval: What is the Mechanism?

The differential diagnosis for wide complex tachycardia includes all causes of narrow complex tachycardia with bundle branch block, all causes of narrow complex tachycardia with antegrade pre-excitation, ventricular tachycardia, and antidromic and other pre-excited reciprocating tachycardias. The variation in a specific intracardiac interval that causes a subsequent change in the tachycardia cycle length or another intracardiac interval can be diagnostic in these arrhythmias.