715 results match your criteria: "Medicine and Research Center[Affiliation]"
Cancer Res Treat
January 2025
Heart-Immune-Brain Network Research Center, Department of Life Sciences, Ewha Womans University, Seoul, Korea.
Purpose: Ninjury-induced protein 1 (Ninj1) is associated with inflammation and tumor progression and shows increased expression in various cancers. This study aimed to investigate the role of Ninj1 in colitis-associated colorectal cancer (CRC) by focusing on its interaction with 17β-estradiol (E2).
Materials And Methods: Using an azoxymethane (AOM)/dextran sodium sulfate (DSS) mouse model of colitis-associated CRC, wild-type (WT) and Ninj1 knockout (KO) male mice were treated with or without E2.
J Clin Med
December 2024
Department of Otolaryngology-Head & Neck Surgery, King Saud University, Riyadh 11411, Saudi Arabia.
Traditional imaging techniques have limited efficacy in detecting occult cervical lymph node (LN) metastases in head and neck squamous cell carcinoma (HNSCC). Positron emission tomography/computed tomography (PET-CT) has demonstrated potential for assessing HNSCC, but the literature on its efficacy for detecting cervical LN metastases is scarce and exhibits varied outcomes, hindering comparisons. To compare the efficacy of CT, MRI, PET-CT, and US for detecting LN metastasis in HNSCC with clinically negative neck lymph nodes.
View Article and Find Full Text PDFPharmacol Res
January 2025
Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, Würzburg 97078, Germany; Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Bunsen-Kirchhoff-Str. 11, Dortmund 44139, Germany; Comprehensive Heart Failure Center, University Hospital of Würzburg, Am Schwarzenberg 15, Würzburg 97078, Germany. Electronic address:
Cancer Res Treat
December 2024
College of Pharmacy, Seoul National University, Seoul, Korea.
Purpose: This study examined the roles of nuclear factor erythroid 2-related factor 2 (NRF2) and programmed death ligand 1 (PD-L1) in colon carcinogenesis, underscoring on sex and differences in tumor location.
Materials And Methods: A total of 378 participants were enrolled from Seoul National University Bundang Hospital: 88 healthy controls (HC), 139 patients with colorectal adenoma (AD), and 151 patients with colorectal cancer (CRC). Quantitative real-time polymerase chain reaction (PCR), methylation-specific PCR, and immunohistochemistry (IHC) were performed utilizing tumor samples from patients and normal mucosa in the HC group.
Eur Heart J Cardiovasc Pharmacother
December 2024
Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Vorarlberg, Austria.
Objectives: This review aims to examine the evidence on the benefits and risks of lipid lowering drugs in patients with liver disease. Elevated liver enzyme levels often lead to cautious discontinuation of these drugs, potentially withholding from patients their benefit in reducing cardiovascular disease morbidity and mortality.
Methods And Results: Using a literature search of PubMed, we examine the efficacy and safety profiles of various lipid lowering agents, including statins, ezetimibe, bempedoic acid, PCSK9 inhibitors, fibrates, and icosapent ethyl, focusing particularly on their potential side effects related to liver health.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Duisburg, Germany.
Surg Open Sci
December 2024
Department of Surgery, Stanford University; 300 Pasteur Drive, Stanford, CA 94305, USA.
Objective: We aimed to determine the most important perceived barriers to the implementation of self-administered training and assessment in surgical education according to subject matter experts. With these findings, design thinking was used to explore possible interventions and develop a theory of change for overcoming identified barriers. Specifically, implementation was focused on expanding the surgical skills of associate clinicians (ACs) in low-to-middle-income countries (LMICs).
View Article and Find Full Text PDFUirusu
December 2024
Department of Microbiology, Faculty of Medicine and Research Center for Global and Local Infectious Diseases, Oita University, Oita, Japan.
Medicine (Baltimore)
November 2024
Sleep Medicine Research Group, Sleep Medicine and Research Center, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Ann Thorac Med
October 2024
Department of Internal Medicine, Sleep Medicine and Research Center, Sleep Medicine Research Group, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Nucl Med Biol
December 2024
Department of Medicine and Research Center on Aging, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Background: Ketone metabolism has been studied using positron emission tomography (PET) with the radiotracers [C]acetoacetate and [C]β-hydroxybutyrate. However, whether these two radiotracers actually yield equivalent estimates of cerebral and myocardial ketone metabolism has not yet been investigated. This study aimed to investigate and compare the kinetics of both tracers in the brain and heart of healthy rats under varying levels of circulating ketones at baseline and after a single-dose exogenous ketone ester (KE) supplement.
View Article and Find Full Text PDFKorean J Gastroenterol
October 2024
Department of Internal Medicine and Research Center for Sex-Gender-Specific Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Background/aims: Irritable bowel syndrome (IBS) is a chronic, intractable functional disease. It is inferred that fecal microbiota transplantation (FMT) may have favorable efficacy on IBS by gut microbial modification. The aim of this study was to investigate the efficacy of FMT for improving severity in patients with IBS.
View Article and Find Full Text PDFInt J Cancer
February 2025
Department of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul, South Korea.
This study investigated the role of Ninjurin1 (Ninj1), encoding a small transmembrane protein, in colitis-associated colon tumorigenesis in relation to sex hormones. Male and female wild-type (WT) and Ninj1 knockout (KO) mice were treated with azoxymethane (AOM) and dextran sulfate sodium (DSS), with or without testosterone propionate (TP). At week 2 (acute colitis stage), Ninj1 KO exhibited an alleviation in the colitis symptoms in both male and female mice.
View Article and Find Full Text PDFInt J Cardiol Heart Vasc
August 2024
Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Germany.
Int J Cardiol Heart Vasc
December 2024
Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany.
Neurology
November 2024
From the Department of Neurology (G.S.), Dayanand Medical College & Hospital, Ludhiana, India; Center for Global Health and School of Sciences (H.H.G.), Universidad Peruana Cayetano Heredia; Cysticercosis Unit (H.H.G.), Instituto Nacional de Ciencaia Neurologicas, Lima, Peru; School of Medicine and Research Center (O.H.D.B.), Universidad Espiritu Santo-Ecuador, Samborondón; Albert Einstein College of Medicine (C.C.), Bronx, NY; Department of Clinical & Experimental Epilepsy (J.W.S.), UCL Queen Square Institute of Neurology, London; and Chalfont Centre for Epilepsy (J.W.S.), Chalfont St Peter, United Kingdom.
Am J Trop Med Hyg
December 2024
Department of Neurosurgery, INTERHOSPITAL S.A., Guayaquil, Ecuador.
Lancet Diabetes Endocrinol
November 2024
Univ Rouen Normandie, Inserm, NorDiC UMR 1239, Rouen, France; Department of Endocrinology, Diabetes and Metabolic Diseases, Rouen, France.
Aberrant G-protein coupled receptor (GPCR) expression is highly prevalent in cortisol-secreting primary bilateral macronodular adrenal hyperplasia (PBMAH) and unilateral adenomas. The aberrant expression of diverse GPCRs and their ligands play an important role in the over-function of various endocrine tumours. Examples include aberrant expression of MC2R, 5-HT4R, AVPR1A, LHCGR, and GnRHR in primary aldosteronism; GCGR, LHCGR, and 5-HT4R in phaeochromocytomas and paragangliomas; TRHR, GnRHR, GIPR, and GRP101 in pituitary somatotroph tumours; AVPR2, D2DR, and SSTR5 in pituitary corticotroph tumours; GLP1R, GIPR, and somatostatin receptors in medullary thyroid carcinoma; and SSTRs, GLP1R, and GIPR in other neuroendocrine tumours.
View Article and Find Full Text PDFExpert Rev Anti Infect Ther
December 2024
School of Medicine and Research Center, Universidad Espíritu Santo - Ecuador, Samborondón, Ecuador.
Introduction: Calcifications are the end stage of many parenchymal brain cysticerci and may occur either spontaneously or as the result of treatment with cysticidal drugs. These lesions, traditionally considered inert and asymptomatic, have been associated with several complications that seem to be mostly related to brain damage and inflammation ensuing as the result of the exposure of the host's immune system to parasitic antigens trapped within calcifications.
Areas Covered: This review, based on the search of different electronic databases up to May 2024, focuses on the reported correlates and complications of calcified cysticerci (chronic headaches, seizures/epilepsy, hippocampal atrophy/sclerosis, gliomas), and the different interventions developed for their prevention and treatment.
J Endocr Soc
August 2024
Division of Endocrinology, Department of Medicine and Research Center, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada, H2X 0A9.
Objective: To assess the usefulness of the upright posture stimulation test (UPT) in the confirmation of primary aldosteronism (PA) in patients in whom saline tests (ST) were inconclusive.
Methods: One hundred eighty-seven adult patients with possible PA were retrospectively included and compared to 25 control subjects. Blood samples were obtained after a 1-hour supine posture and during 2 hours of ambulation.
Naunyn Schmiedebergs Arch Pharmacol
September 2024
Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Duisburg, Germany.
Thrombin supports coagulation-independent inflammation via protease-activated receptors (PAR). PAR4 is specifically increased in obese human atria, correlating with NLRP3 inflammasome activation. PAR4-mediated NLRP3 inflammasome activation in atrial cardiomyocytes is not known, nor have signaling partners been identified.
View Article and Find Full Text PDFJ Affect Disord
January 2025
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address:
Background: Anxiety disorders, major psychiatric disorders (e.g., schizophrenia and major affective disorders), and neurodevelopmental disorders (e.
View Article and Find Full Text PDFClin Neurol Neurosurg
November 2024
School of Medicine and Research Center, Universidad Espíritu Santo - Ecuador, Samborondón, Ecuador. Electronic address:
Objective: It has been suggested that choroid plexus calcifications (CPC) may be associated with glymphatic system dysfunction and with disturbed slow-wave (N3) sleep. If this is the case, volumetric analysis of CPC could be used to estimate the functional ability of the glymphatic system. However, data on this association is limited.
View Article and Find Full Text PDFInt J Cardiol Heart Vasc
October 2024
Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen, University of Essen Medical School, University Duisburg-Essen, Essen, Germany.