A Pilot Study of Gene Expression Analysis in Peripheral Blood Mononuclear Cells in Response to a Hypocaloric Mediterranean Diet.

Background: Few studies have examined gene expression in peripheral blood mononuclear cells (PBMCs) after a dietary intervention.

Objective: Our study is aimed at evaluating in a pilot study the peripheral blood gene expression in obese patients after weight loss secondary to a hypocaloric Mediterranean diet.

Design: A sample of 11 obese subjects without metabolic syndrome was enrolled.

Brain derived neurotrophic factor (BDNF) polymorphism rs 10767664 affects metabolic parameters after weight loss secondary to high fat hypocaloric diet with Mediterranean pattern.

Objective: We evaluated the effect of the genetic variant rs10767664 of BDNF gene on anthropometric and biochemical changes after weight loss secondary to a high-fat hypocaloric diet with a Mediterranean dietary pattern.

Patients And Methods: A sample of 277 obese subjects was recruited. After subjects met the inclusion criteria, they received a nutritional intervention with a high-fat hypocaloric diet [36% of carbohydrates, 40% of fats (60.

Histopathological differences in patients with biopsy-proven non-alcoholic fatty liver disease with and without type 2 diabetes.

Background And Aims: Prevalence of non-alcoholic fatty liver disease (NAFLD) in developed countries is 30% in the general population and 50% in patients with type 2 diabetes mellitus (T2DM). The aim of this study was to compare the severity of NAFLD, as assessed by liver biopsy and using the non-invasive index NAFLD Fibrosis Score (NFS), in subjects with and without T2DM.

Patients And Methods: The study sample consisted of 217 patients with biopsy-proven NAFLD.

RS 10767664 gene variant in Brain Derived Neurotrophic Factor (BDNF) affect metabolic changes and insulin resistance after a standard hypocaloric diet.

Background: Role of BDNF variants on change in body weight and cardiovascular risk factors after weight loss remains unclear in obese patients.

Objective: Our aim was to analyze the effects of rs10767664 BDNF gene polymorphism on body weight, cardiovascular risk factors and serum adipokine levels after a standard hypocaloric diet in obese subjects.

Design: A Caucasian population of 80 obese patients was analyzed before and after 3months on a standard hypocaloric diet.

Predictive factors of non-alcoholic steatohepatitis: relationship with metabolic syndrome.

Unlabelled: Non-alcoholic fatty liver disease (NAFLD) has been proposed as the hepatic manifestation of the metabolic syndrom (Ms), with insulin resistance (IR) as the common pathophysiological mechanism.

Methods: We included 145 patients with NAFLD proven liver biopsy. NAS-score was employed to grading NAFLD.