Diversity and Surgical Management of Intracranial Fungal Infections.

Intracranial fungal infection is a rare entity. This disease is mainly concentrated in dry and hot climates, such as India, Africa, California, and usually occurs in patients with immune deficiency. Now, we retrospectively analyzed the clinical manifestations, pathologic manifestations, imaging features, surgical methods, and prognosis of 4 patients with fungal infection who were confirmed by postoperative pathology.

Bilateral Transient Dilated and Fixed Pupils After Microvascular Decompression: Rare Clinical Experience.

Microvascular decompression (MVD) has a satisfactory safety, and it is the only surgical treatment for neurovascular compression diseases, such as hemifacial spasm, trigeminal neuralgia, and glossopharyngeal neuralgia, from the perspective of etiology. Bilateral dilated and fixed pupils have long been regarded as a sign of life threatening, which is common in patients with cerebral herniation due to cranial hypertension. However, transient dilated pupils after MVD have not been previously reported.

A prospective, multicenter, real-world observational study evaluating the impact of tibial runoff on clinical outcomes after endovascular therapy for femoropopliteal lesions: Research protocol.

Introduction: Current evidence indicates endovascular intervention is a safe and effective treatment for peripheral artery disease of the lower extremity. However, the clinical outcome of endovascular intervention for femoropopliteal lesions has been shown to be affected by the status of tibial runoff. It remains unclear whether endovascular intervention for tibial runoff is associated with additional benefits.

OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.

The transcriptional regulators YAP and TAZ play important roles in development, physiology, and tumorigenesis and are negatively controlled by the Hippo pathway. It is yet unknown why the YAP/ TAZ proteins are frequently activated in human malignancies in which the Hippo pathway is still active. Here, by a gain-of-function cancer metastasis screen, we discovered OTUB2 as a cancer stemness and metastasis-promoting factor that deubiquitinates and activates YAP/TAZ.

Spontaneous dissection in the left main coronary artery.

We present two cases of spontaneous left main stem coronary artery dissection. One was underdiagnosed with suboptimal percutaneous coronary artery intervention followed by acute vessel occlusion again during the hospitalization. The other one was identified and confirmed by intravascular ultrasound, followed by conservative medical treatment, with completed healing of SCAD during two-month follow up.

[Clinical characteristics and treatment of AO/OTA A2.3 intertrochanteric fractures with posterior coronal plane fractures].

Objective: To explore the characteristics, the operative techniques and effect of AO/OTA A2.3 intertrochanteric fractures with posterior coronal fractures.

Methods: From January 2011 to January 2014, 33 patients suffered from AO/OTA A2.

Health-related quality of life of postmenopausal Chinese women with hormone receptor-positive early breast cancer during treatment with adjuvant aromatase inhibitors: a prospective, multicenter, non-interventional study.

Background: Estimating quality of life (QoL) in patients with breast cancer is of importance in assessing treatment outcomes. Adjuvant endocrine therapy is widely used for hormone receptor-positive (HR+) early-stage breast cancer (EBC), and evidence suggests that aromatase inhibitors (AIs) may improve QoL for these patients. This study evaluated QoL in postmenopausal Chinese patients with HR+ EBC taking AIs.

Can posterior dynamic stabilization reduce the risk of adjacent segment deterioration?

Aim: The aim of this study was to systematically review the relevant literature to develop a benchmark for the incidence of adjacent segment degeneration (ASDeg) and adjacent segment disease (ASDis) following the posterior dynamic stabilization (PDS) procedure and to investigate whether conclusions can be made with regard to the isolated PDS procedure in reducing the risk of ASDeg and ASDis compared with fusion, and with regard to the role of additional PDS devices implanted adjacent to fusion in protecting from ASDeg and ASDis caused by the neighboring fusion.

Material And Methods: We retrieved electronic databases of Medline, Ovid and Cochrane Central Registry of Controlled Trials, combined with a supplemental hand search. Thirty-one articles met our inclusion criteria.

SPECT imaging of dopamine transporters with (99m)Tc-TRODAT-1 in major depression and Parkinson's disease.

To investigate dopamine transporter in major depressive disorder and Parkinson's disease, the authors obtained single photon emission computed tomography (SPECT) brain images from 13 patients with major depression, 17 Parkinson's disease patients, and 10 healthy volunteers by using 99mTc-TRODAT-1. The authors found the 99mTc-TRODAT-1 radio signal in the striatum was reduced in the majority of patients with major depressive disorder, and this decrease was even more severe in patients with Parkinson's disease. The results support the hypothesis of dopamine hypofunction in major depressive disorder and suggest that deficient dopamine transporter may be involved in the etiology of severe major depressive disorder.

[Comparison of the relativity of MRI appearance of cartilage injuries and postoperative effect of arthroscope on articular cartilage disease of knee].

Objective: To analyze the indication of arthroscope by examining the correlations between cartilage injury degree confirmed by MRI and postoperative effect.

Methods: From Aug. 2005 to April 2008, 87 cases with knee osteoarthritis were treated by arthroscopes including 44 males and 43 females,aged from 16 to 67 years (means 46.

[Regulation of integrin beta1 mRNA expression by mechanical stress in human periodontal ligament fibroblasts].

Objective: To investigate the effect of different kinds of mechanical stress on the mRNA expression of integrin beta1 subunit in cultured human periodontal ligament fibroblasts (hPDLF).

Methods: To scalp and remove the periodontal ligament attached to the mid-third part of the fresh root of young premolars extracted for the cause of orthodontics. Cultured hPDLF by the method of digesting by I-type collagenase combining with tissue adhering.

[The management of fungal maxillary sinusitis under endoscopic surgery by dual approaches].

Objective: To investigate the effects of management for fungal maxillary sinusitis under endoscopic surgery by dual approaches (canine fossa and natural ostium of maxillary sinus).

Method: Forty cases of fungal maxillary sinusitis were operated under endoscope by dual approaches. The patients were hospitalized in the department of Otolaryngology, Second Affiliated Hospital, School of Medicine Zhejiang University during the period of 1998 to 2004.