Macrophage immunomodulatory activity of nanoemulsion via activation of P65/JNK/ikkαsignaling pathway and regulation of Th1/Th2 Cytokines.

Nanoemulsions (NE) are used widely in pharmaceutical drug formulations and vaccine preparation, and (ASPS) is a natural bioactive compound with immunostimulatory activity. Therefore, NE-loaded ASPS is expected to provide immunological enhancement for effective treatment. In the present study, (ASPS was encapsulated into nanoemulsions, the resultant ASPS-NE were coated with a negative charge, and the immune enhancement mechanism of these ASPS-NE formulations was analyzed.

Ferulic acid isolated from propolis inhibits porcine parvovirus replication potentially through Bid-mediate apoptosis.

Propolis from honeybee hives, which is a traditional Chinese medicine, is widely used in veterinary clinics. Many compounds have been identified and isolated from propolis. Ferulic acid (FA), one of the propolis components, previous studies have proven that it has antiviral effects.

The Adjuvant Activity of Epimedium Polysaccharide-Propolis Flavone Liposome on Enhancing Immune Responses to Inactivated Porcine Circovirus Vaccine in Mice.

Objectives. The adjuvant activity of Epimedium polysaccharide-propolis flavone liposome (EPL) was investigated in vitro and in vivo. Methods.

The adjuvanticity of ophiopogon polysaccharide liposome against an inactivated porcine parvovirus vaccine in mice.

In this study, the adjuvant activity of ophiopogon polysaccharide liposome (OPL) was investigated. The effects of OPL on the splenic lymphocyte proliferation of mice were measured in vitro. The results showed that OPL could significantly promote lymphocyte proliferation singly or synergistically with PHA and LPS and that the effect was better than ophiopogon polysaccharide (OP) at most of concentrations.

Antioxidative and immunological activities of ophiopogon polysaccharide liposome from the root of Ophiopogon japonicus.

The antioxidative and immunoregulatory activities of ophiopogon polysaccharide liposome (OPL) were investigated. The results demonstrated that the radical-scavenging activity increased along with the increasing of OPL concentrations, and the scavenging capability of OPL was slightly stronger than ophiopogon polysaccharide (OP) in vitro. In vivo, OPL at high and medium doses could significantly improve the levels of SOD and GSH-Px, and decrease the levels of MPO, XOD and MDA compared with OP.

The anti-porcine parvovirus activity of nanometer propolis flavone and propolis flavone in vitro and in vivo.

Objectives. The present study was conducted to evaluate the activity of nanometer propolis flavone (NPF) on inhibiting porcine parvovirus (PPV) in vitro and in vivo. Methods.

Ophiopogon polysaccharide liposome can enhance the non-specific and specific immune response in chickens.

The purpose of this study is to investigate the immune-enhancing activity of ophiopogon polysaccharide liposome (OPL). In non-specific immune response experiment, the phagocytosis and cytokines secretion of peritoneal macrophages in vitro and in vivo were performed. In specific immune response experiment, the activity of OPL was measured on chickens which were vaccinated with Newcastle disease (ND) vaccine and then challenged with ND virus at 49-old-day.