30 results match your criteria: "Medical school of Casablanca[Affiliation]"
Front Public Health
July 2022
Pfizer Inc., Tunis, Tunisia.
Naunyn Schmiedebergs Arch Pharmacol
June 2021
Laboratory of Cellular and Molecular Pathology, Faculty of Medicine and Pharmacy of Casablanca, University Hassan II, Casablanca, Morocco.
V-domain Ig suppressor of T cell activation (VISTA) is a transmembrane protein that plays a crucial role in the regulation of antitumor immunity. Therapeutic intervention that inhibits the VISTA pathway constitutes a new approach in the treatment of cancer. The aim of the present study was to provide a bibliometric literature review of VISTA research in the field of cancer.
View Article and Find Full Text PDFCurr Drug Targets
July 2021
Genetics and Molecular Pathology Laboratory, Medical school of Casablanca, Hassan II University, Casablanca, Morocco.
Triple-negative breast cancer (TNBC) can be distinguished from other breast malignancies by the lack of expression of estrogen receptors (ER), progesterone receptors (PR) as well as human epidermal growth factor receptor 2 (HER2). TNBC is associated with adverse clinical outcomes and high risk of metastasis. Currently, several clinical and translational reports are focusing on developing targeted therapies for this aggressive cancer.
View Article and Find Full Text PDFMol Biol Rep
January 2020
Faculty of Medicine and Odontostomatology, University of Sciences Techniques and Technologies of Bamako, Point G, BP. 1805, Bamako, Mali.
Glutathione S-transferase genes, known to be highly polymorphic, are implicated in the process of phase II metabolism of many substrates, including xenobiotics, anticancer and anti-infective drugs. The detoxification activity is linked to individual genetic makeup. Therefore, the identification of alleles and genotypes in these genes within a population may help to better design genetic susceptibility and pharmacogenetic studies.
View Article and Find Full Text PDFMol Genet Genomic Med
September 2019
INSERM UMR1141, Sorbonne Paris Cité, DHU PROTECT, Paris Diderot University, Robert Debré Hospital, Paris, France.
Introduction: RNA polymerase III (Pol III)-related leukodystrophies are a group of autosomal recessive neurodegenerative disorders caused by mutations in POLR3A and POLR3B. Recently a recessive mutation in POLR1C causative of Pol III-related leukodystrophies was identified.
Methods: We report the case of a Tunisian girl of 14 years of age who was referred to our department for evaluation of progressive ataxia that began at the age of 5.
TH Open
April 2019
Haemophilia Comprehensive Care Centre, Charlotte Maxeke Johannesburg Hospital, Department of Molecular Medicine and Haematology, National Health Laboratory Service and Faculty of the Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
Optimizing hemophilia care remains challenging in developing countries. Burden-of-disease studies are important to develop strategies for improving hemophilia care. The HAEMOcare study evaluated the factors contributing to hemophilia-related orthopedic disease burden in developing countries.
View Article and Find Full Text PDFPathobiology
November 2018
Laboratory of Genetics and Molecular Pathology, Medical School of Casablanca, Casablanca, Morocco.
Background: The purpose of our case control study is to explore the potential association of tumor protein 53 (TP53) c.215G>C, p. (Arg72Pro) polymorphism (rs1042522) with the risk of breast cancer (BC) development in the Moroccan population.
View Article and Find Full Text PDFGene
June 2018
Genetics and Molecular Pathology Laboratory, Medical School of Casablanca, University Hassan II, 19 Rue Tarik Ibnou Ziad, BP. 9154 Casablanca, Morocco.
Objective: The aim of the present study was to investigate the association of I/D polymorphisms of ACE gene is associated with resistant hypertension and essential controlled hypertension.
Results: Our results show that the homozygous mutant genotype DD was more represented among resistant than controlled (58.1% vs 41.
BMC Genet
September 2016
Genetics and Molecular Pathology Laboratory, Medical school of Casablanca, Casablanca Hassan II University, 19 Rue Tarik Ibnou Ziad, B.P. 9154, Casablanca, Morocco.
Background: Breast cancer is the most common cause of cancer death among women. Several studies have investigated the relationship between the C3435T polymorphism of ABCB1 gene and risk of breast cancer; but the results are conflicting. In the present study, we sought to assess the relationship between the C3435T polymorphism in ABCB1 gene and the risk of breast cancer in a sample of the Moroccan population.
View Article and Find Full Text PDFEur J Med Genet
June 2016
Institut Pasteur, laboratoire de génétique moléculaire humaine, 20360 Casablanca, Morocco. Electronic address:
Deafness is one of the most common genetic diseases in humans and is subject to important genetic heterogeneity. The most common cause of non syndromic hearing loss (NSHL) is mutations in the GJB2 gene. This study aims to update and evaluate the spectrum of GJB2 allele variants in 152 Moroccan multiplex families with non syndromic hearing loss.
View Article and Find Full Text PDFBMC Res Notes
April 2016
Mohammed VI Cancer Treatment Center, Ibn Rochd University Hospital, Casablanca, Morocco.
Background: BRCA1 and BRCA2 genes explain a large part of hereditary breast cancer. Several studies have shown that BRCA1 and BRCA2 tumors exhibit some specific morphological and immunohistochemical characteristics. The aim of our study is to compare the clinicopathological characteristics between Moroccan breast cancers associated or not with BRCA1 and BRCA2 mutations.
View Article and Find Full Text PDFBMC Cancer
February 2016
Department of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Background: Breast cancer (BC) is the most prevalent cancer in women and a major public health problem in Morocco. Several Moroccan studies have focused on studying this disease, but more are needed, especially at the genetic and molecular levels. Therefore, we investigated the potential association of several functional germline variants in the genes commonly mutated in sporadic breast cancer.
View Article and Find Full Text PDFBMC Res Notes
December 2015
Genetics and Molecular Pathology Laboratory, Medical School of Casablanca, University Hassan II, 19 Rue Tarik Ibnou Ziad, BP. 9154, Casablanca, Morocco.
BMC Neurol
November 2015
Genetics and Molecular Pathology Laboratory, Medical school of Casablanca, Hassan II University, Casablanca, Morocco.
Background: X-linked adrenoleukodystrophy (X-ALD; OMIM: 300100) is the most common peroxisomal disease caused by mutations in the ATP-binding cassette, sub-family D member 1 gene or ABCD1 (geneID: 215), the coding gene for the adrenoleukodystrophy protein (ALDP), which is an ATP-binding transport protein associated to an active transport of very long chain fatty acids (VLCFAs). Dysfunction of ALDP induces an accumulation of VLCFAs in all tissues leading to a neurodegenerative disorder that involves the nervous system white matter.
Case Presentation: In our case report, magnetic resonance imaging (MRI) as well as the high levels of VLCFAs prompted the diagnosis the X-ALD.
Springerplus
May 2015
Genetics and Molecular Pathology Laboratory, Medical School of Casablanca, 19 Rue Tarik Ibnou Ziad, Casablanca, BP 9154 Morocco.
Chronic myeloid leukemia (CML), as most of cancers results from a complex interaction between genetic or non genetic factors. Exposures to xenobiotics endogenous or exogenous associated with a reduced individual ability in detoxifying activity, constitutes a risk of developing cancer. It is known that polymorphism of glutathione S-transferases (GSTs) genes affects the detoxification of xenobiotics.
View Article and Find Full Text PDFTurk J Gastroenterol
December 2014
Laboratory of Medical Genetics, Medical School of Casablanca, Casablanca, Morocco; Center of Doctoral Sciences " in Health Sciences", University Ain Chock Hassan ii, Casablanca, Morocco.
Background/aims: IBD (Crohn's disease and Ulcerative Colitis) is chronic and multifactorial disease of the gastrointestinal tract. Till now, his pathogenesis remains unclear. It involves innate immunity, environmental component and genetic predisposition.
View Article and Find Full Text PDFBMC Cancer
February 2015
Genetics and Molecular Pathology Laboratory, Medical school of Casablanca, Casablanca, Morocco.
Background: Identification of specific mutations in cancer patients may lead to the discovery of genes, which can affect susceptibility and/or prognosis. It has previously been reported that mutations in BRCA1 and BRCA2 genes are linked to breast cancer. Here, we evaluated the use of the High Resolution Melting (HRM) approach to screen for mutations in exon 11 of BRCA1 gene in Moroccan patients.
View Article and Find Full Text PDFSpringerplus
February 2015
Laboratory of Genetics and Molecular Pathology-Medical School of Casablanca, 19 rue Tarik Ibn Ziad, P.C 9154 Casablanca, Morocco ; University Hassan II Ain Chock, Center Of Doctoral Sciences "In Health Sciences", Casablanca, Morocco.
Purpose: The cell-cycle checkpoint kinase 2 (CHEK2) is an important signal transducer of cellular responses to DNA damage, whose defects has been associated with increased risk for breast cancer. The CHEK2 1100delC mutation has been reported to confer a twofold increased risk of breast cancer among carriers. The frequency of the mutation varies among populations.
View Article and Find Full Text PDFTumour Biol
December 2014
Genetics and Molecular Pathology Laboratory, Medical School of Casablanca, University Hassan II, Casablanca, Morocco,
TP53 is a tumor suppressor gene involved in cell cycle progression control, DNA damage repair, genomic stability, and apoptosis. Some polymorphisms in this gene have been associated with the development of a number of cancers including breast carcinoma. PIN3 Ins16bp polymorphism has been widely studied in different populations for an association with breast cancer risk.
View Article and Find Full Text PDFBMC Res Notes
August 2014
Laboratory of Medical Genetics- Medical school of Casablanca, Faculté de Médecine et de Pharmacie de Casablanca, 19, rue Tarik ibn ziad, Casablanca, Morocco.
Background: Inflammatory bowel diseases (IBD) are chronic diseases of the gastrointestinal tract. Although their pathogenesis is unclear, the combination of genetic predisposition and environmental components are believed to be the main cause of these diseases. Recently, many variants in interleukin 23 receptor (IL23R) and autophagy-related 16-like 1 (ATG16L1) genes have been associated with the disease.
View Article and Find Full Text PDFTumour Biol
November 2014
Genetics and Molecular Pathology Laboratory, Medical school of Casablanca, University Hassan II, 19 Rue Tarik Ibnou Ziad, BP., 9154, Casablanca, Morocco,
Multidrug resistance gene 1 (MDR1) is known for its involvement in the detoxification through the active transport of toxic compounds from diverse origins outside the cells. These compounds could cause injury to cell DNA, which might lead in cancer like chronic myeloid leukemia (CML). Individual inherited genetic differences related to polymorphism in detoxification enzymes could be an important factor not only in carcinogen metabolism but also in susceptibility of cancer.
View Article and Find Full Text PDFMed Oncol
July 2014
Genetics and Molecular Pathology Laboratory, Medical School of Casablanca, University Hassan II, 19 Rue Tarik Ibnou Ziad, BP. 9154, Casablanca, Morocco,
The glutathione S-transferases (GSTs) are phase II xenobiotic metabolizing enzymes known to be involved in the detoxification of carcinogens and anticancer drugs. Individual genetic variation linked to inherited polymorphisms of GSTT1 and GSTM1 leading to a complete loss of enzyme activity could expose subjects to develop cancer or to induce drug resistance. Indeed, despite the impressive results obtained with the imatinib, some patients with chronic myeloid leukemia (CML) fail to achieve the expected results or develop resistance.
View Article and Find Full Text PDFMed Oncol
January 2014
Genetics and Molecular Pathology Laboratory, Medical School of Casablanca, University Hassan II, 19 Rue Tarik Ibnou Ziad, BP 9154, Casablanca, Morocco,
In the spite of the impressive results achieved with imatinib in chronic myeloid leukemia (CML) patients, differences in patient's response are observed, which may be explained by interindividual genetic variability. It is known that cytochrome P450 enzymes play a major role in the metabolism of imatinib. The present study aimed to understand the functional impact of CYP2B6 15631G>T polymorphism on the response of imatinib in CML patients and its relation to CML susceptibility.
View Article and Find Full Text PDFIndian J Hum Genet
April 2013
Genetics and Molecular Pathology Laboratory, Medical School of Casablanca, Morocco.
Ethiop J Health Sci
July 2013
Genetics and Molecular Pathology Laboratory, Medical School of Casablanca, Morocco.
Background: Breast cancer is the most common cancer affecting women all over the world. In addition to hormonal and environmental causes, family history is emerging as an important risk factor in the etiology of this disease. The aim of the present study is thus to compare the clinico-pathological features of familial and sporadic breast cancer in Moroccan patients.
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