Synergism of Specific Maca Phenotypes () in Combination with Saw Palmetto () Extract for Chemoprevention of Prostate Cancer as Determined in In Vitro Cytotoxicity Assays on Human Epithelial and Prostate Cancer Cells.

Selected phenotypes of dried maca () hypocotyls and supercritical CO extract (USPlus) of saw palmetto () were used to determine their targeted, cytotoxic action in prostate cancer cells. Fingerprinting by HPLC-MS and PCA analysis showed compositional differences in glucosinolates, amides, macamides, and other alkaloids, which varied based on the color and the size of hypocotyls. These phytochemical differences translated into a higher antioxidant potential of red maca than black maca samples.

Optimizing Green Extraction Methods for Maximizing the Biological Potential of Dandelion, Milk Thistle, and Chamomile Seed Extracts.

This study investigates the underutilized potential of agri-crops from the family by employing sustainable and green technologies (supercritical fluid, ultrasound, and Soxhlet extractions) to enhance the recovery of bioactive compounds. A total of 21 extracts from native and waste seeds of dandelion, milk thistle, and chamomile were systematically compared utilizing a combination of solvents (supercritical CO and absolute or aqueous ethanol). Supercritical CO extraction yielded up to 281 mg/g of oils from native seeds, while conventional techniques with ethanol recovered an additional 142 mg/g of extracts from waste seeds.

Biological Markers of Myeloproliferative Neoplasms in Children, Adolescents and Young Adults.

Myeloproliferative neoplasms (MPNs) are clonal hematopoietic cancers characterized by hyperproliferation of the myeloid lineages. These clonal marrow disorders are extremely rare in pediatric patients. MPN is reported to occur 100 times more frequently in adults, and thus research is primarily focused on this patient group.

A Global Regional Comparison of the Risk of Breast Cancer in Woman Using Oral Contraceptives-Systematic Review and Meta-Analysis.

: Incidence of breast cancer (BrCa) may be correlated with country development, with a rise in cases anticipated in regions of the world that are currently undergoing an economic transformation. Herein, differences with regard to the occurrence of breast cancer between individual countries may depend on the distribution of risk factors, the level of early detection, also ethnicity and race, as well as clinical characteristics. The aim of our study was to identify and then investigate observational studies in which the risk of breast cancer was associated with the use of oral hormonal contraceptives (OCs), with particular emphasis on geographic region, and to conduct a systematic review and meta-analysis of the obtained data.

Potential Use of Exosomal Non-Coding MicroRNAs in Leukemia Therapy: A Systematic Review.

Leukemia is a heterogeneous group of hematological malignancies. Despite the enormous progress that has been made in the field of hemato-oncology in recent years, there are still many problems related to, among others, disease recurrence and drug resistance, which is why the search for ideal biomarkers with high clinical utility continues. Research shows that exosomes play a critical role in the biology of leukemia and are associated with the drug resistance, metastasis, and immune status of leukemias.

Synthesis of spherical and rods-like titanium oxide nanoparticles (TiO NPs) and evaluation of their cytotoxicity towards colon cells in vitro.

Titanium oxide nanoparticles (TiO NPs) are currently used as ingredients in medicines and sunscreens. Unfortunately, recent information about TiO NPs indicates their undesirable biological effect on colon cells. Therefore, the aim of this work was to synthesize and evaluate the physicochemical characterization of spherical (TiO NSs) and rods-like (TiO NRs) NPs, followed by assessment their cytotoxicity.

Prime suspect or collective responsibility: Impact of specific lymph node station dissection on short- and long-term outcomes among locally advanced gastric cancer patients after neoadjuvant chemotherapy.

Background: Lymphatic route is the main pathway for gastric cancer (GC) spread, and lymph node (LN) involvement is a major prognostic factor after curative resection. The aim of this study was to assess the outcomes of specific LN station dissection.

Methods: Patients with locally advanced (cT2-4N0-3M0) GC who underwent multimodal treatment between 2013 and 2023 were included in the study.

Damsin and neoambrosin: Two sesquiterpene lactones with affinity and different activity for PPAR and TRPA1 receptors.

Ambrosia maritima L. (family Asteraceae) is an annual herb widely distributed throughout the Mediterranean region and Africa. The herb is employed in folk medicine for the treatment of many ailments.

Prevalence and associations of neurodevelopmental and mental health disorders with academic and well-being challenges among nursing and midwifery students: A cross-sectional study.

Introduction: This study highlights the significant stress faced by nursing and midwifery students stemming from the rigorous requirements of their curriculum, which includes both demanding theoretical and practical elements. This study aims to identify the causes and manifestations of learning environment stress among midwifery and nursing students.

Methods: A cross-sectional study in Lithuania, Poland and Latvia was employed to evaluate students' learning challenges and neurodiversity using 40 different questions assessed on a Likert scale.

The usefulness of botulinum toxin injections in oncology - Clinical and laboratory perspectives.

The use of botulinum toxins in various oncological conditions brings long-term results in the treatment of chronic pain without burdening internal organs, as is the case with the use of opioids. Numerous reports indicate a possible apoptotic effect achieved in vitro and in vivo. Most literature data suggest that using botulinum toxins to support oncological treatment gives positive results, and in most cases, it is free of side effects.

Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis.

Background And Objectives: The impact of viral infections on disease susceptibility and progression has predominantly been studied in patients with relapse-onset MS (RMS). Here, we determined immune responses to ubiquitous viruses in patients with primary progressive MS (PPMS).

Methods: Antibody responses to Epstein-Barr virus (EBV), specifically to the latent EBV nuclear antigen 1 and the lytic viral capsid antigen VCA, human herpesvirus 6 (HHV-6), human cytomegalovirus (HCMV), and measles virus were determined in a cohort of 68 PPMS patients with a mean follow-up of 8 years and compared with 66 healthy controls matched for sex and age.

Association between smoking status, toxicity and survival in the checkpoint inhibitor immunotherapy.

Introduction: Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy by enhancing T-cell-mediated immune responses against tumors. However, their use can lead to immune-related adverse events (irAEs), impacting patient outcomes.

Methods: This single-center, observational study investigates the relationship between immune-related adverse events (irAEs) and survival outcomes in 151 patients treated with ICIs, with or without chemotherapy, at the Department of Clinical Oncology and Chemotherapy in the Independent Public Hospital No.

Evaluating Lipiodol Efficacy in Proximal Tubal Occlusion Treatment: Single-Center Experience and Literature Review.

BACKGROUND Tubal infertility caused by proximal occlusion of fallopian tubes is a common cause of female infertility. Lipiodol (ethiodized oil) is an oil-based iodinated contrast medium, previously used in hysterosalpingography, and is now used as a therapeutic agent. This single-center study aimed to evaluate the experience of outcomes from the use of Lipiodol in 96 women with infertility due to fallopian tube occlusion.

Changes in macular ganglion cell and retinal nerve fiber layer thickness during recovery from infection with the B.1.1.7 variant of SARS-CoV-2 in previously hospitalized patients with COVID-19 bilateral pneumonia.

Coronavirus disease 2019 (COVID-19) has been associated with various systemic complications, including potential impacts on ocular health. Recent studies have suggested that COVID-19 may lead to changes in retinal structure, particularly in the neuroretinal and retinal nerve fiber layers (RNFL). This study aimed to examine changes in neuroretinal and RNFL of the optic dics based on optical coherence tomography (OCT) in patients hospitalized due to COVID-19 bilateral pneumonia at 2 time points after discharge.

Chemically synthesized CdSe quantum dots induce apoptosis in AGS gastric cancer cells ROS generation.

CdSe quantum dots (QDs) with size in the range of 3.5-5.8 nm and a zinc blende (ZB) crystal structure were synthesized by the wet chemical method.

Zanubrutinib Versus Bendamustine and Rituximab in Patients With Treatment-Naïve Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: Median 5-Year Follow-Up of SEQUOIA.

JCO SEQUOIA (ClinicalTrials.gov identifier: NCT03336333) is a phase III, randomized, open-label trial that compared the oral Bruton tyrosine kinase inhibitor zanubrutinib to bendamustine plus rituximab (BR) in treatment-naïve patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The initial prespecified analysis (median follow-up, 26.

Synthesis, structure and biological activity of new picolinohydrazonamide derivatives.

Three new thiosemicarbazide derivatives are described in terms of synthesis, structure and biological activity. N'-(Morpholine-4-carbonothioyl)-4-(4-phenylpiperazin-1-yl)picolinohydrazonamide 2-methyltetrahydrofuran hemisolvate, 2CHNOS·CHO, 1, determined at 100 K, has orthorhombic (Pca2) symmetry and exhibits disorder. 4-(4-Phenylpiperazin-1-yl)-N'-(piperidine-1-carbonothioyl)picolinohydrazonamide-dimethylformamide-water (1/1/0.

The effectiveness of acupuncture in cancer pain treatment.

Introduction: In recent years, pain has been recognized as a primary factor significantly diminishing the quality of life in cancer patients. Recent data have prompted the establishment and increased application of non-pharmacological interventions in pain management, such as acupuncture.

Objectives: This review assesses literature from 2018 to 2023 on the impact of acupuncture on pain management and quality of life in cancer patients, with a particular focus on reducing pain intensity.