Chemically synthesized CdSe quantum dots induce apoptosis in AGS gastric cancer cells ROS generation.

CdSe quantum dots (QDs) with size in the range of 3.5-5.8 nm and a zinc blende (ZB) crystal structure were synthesized by the wet chemical method.

Stress among Nursing Students in the Era of the COVID-19 Pandemic.

Introduction: The COVID-19 pandemic has significantly impacted stress levels across various professions, particularly in the medical field. This increase in stress has also affected medical students, including nursing students, who faced unprecedented and challenging circumstances. Nursing students, in particular, experienced added pressure due to observing the frontline experiences of nurses and the new demands placed upon them.

The Impact of Script Concordance Testing on Clinical Decision-Making in Paramedic Education.

This study investigates the effectiveness of the Script Concordance Test (SCT) in enhancing clinical reasoning skills within paramedic education. Focusing on the Medical University of Lublin, we evaluated the SCT's application across two cohorts of paramedic students, aiming to understand its potential to improve decision-making skills in emergency scenarios. Our approach, informed by Van der Vleuten's assessment framework, revealed that while the SCT's correlation with traditional methods like multiple-choice questions (MCQs) was limited, its formative nature significantly contributed to improved performance in summative assessments.

Post-Traumatic Stress Disorder among Polish Healthcare Staff in the Era of the COVID-19 Pandemic.

Introduction: The COVID-19 pandemic has brought many adverse phenomena, particularly in the area of health for both individuals and society as a whole. Healthcare staff also suffered dire consequences.

Aim: The aim of this study was to assess whether the COVID-19 pandemic increased the risk of post-traumatic stress disorder among healthcare professionals in Poland.

Tricuspid Valve Damage Related to Transvenous Lead Extraction.

Background: Damage to the tricuspid valve (TVD) is now considered either a major or minor complication of the transvenous lead extraction procedure (TLE). As yet, the risk factors and long-term survival after TLE in patients with TVD have not been analyzed in detail.

Methods: This post hoc analysis used clinical data of 2631 patients (mean age 66.

Diabetic Mastopathy. Review of Diagnostic Methods and Therapeutic Options.

Diabetic mastopathy is a rare breast condition that may occur in insulin-treated men and women of any age. The etiology is still unclear; however, the autoimmunological background of the disease is highly suspected. The changes in diabetic mastopathy may mimic breast cancer; therefore, its diagnostic process is demanding, and treatment options are not clear and limited.

The Influence of Lead-Related Venous Obstruction on the Complexity and Outcomes of Transvenous Lead Extraction.

Background: Little is known about lead-related venous stenosis/occlusion (LRVSO), and the influence of LRVSO on the complexity and outcomes of transvenous lead extraction (TLE) is debated in the literature.

Methods: We performed a retrospective analysis of venograms from 2909 patients who underwent TLE between 2008 and 2021 at a high-volume center.

Results: Advanced LRVSO was more common in elderly men with a high Charlson comorbidity index.

Evaluation of tourniquet application in a simulated tactical environment.

Background: Application of a tourniquet in a tactical environment is implemented in two ways: the so-called self-aid, which is the application of a tourniquet by the injured, and the so-called buddy aid, which is the application of a tourniquet by the person provide aid. This study aimed to test the quality of tourniquet use in a simulated situation, close quarter battle.

Methods: The study involved 24 injured operators and 72 operators in the whole simulation, implying 12 sections of six individuals.

Association between clinical stage of oral cancer and expression of immunohistochemical markers.

Aim: The aim of this study is to demonstrate the possible correlation between the expression of examined protein markers - p53, EGFR, PCNA, p44/42 in the mass of the tumor and the clinical stage of disease.

Material: 48 patients of the Department and Clinic of Oral and Maxillofacial Surgery, Lublin diagnosed with oral cancer. The control group consisted of 10 patients diagnosed with leukoplakia lesions in the oral cavity.

Psychosocial determinants of disease acceptance in selected mental disorders.

Introduction And Objective: Every mental disorder may cause a number of negative consequences in the personal lives of the patients and their families as well as in their social relations. Acceptance of the disease is a crucial factor in the process of coping with the problems resulting from it. Acceptance of the disease may significantly influence the reduction of negative emotional reactions it causes.

Isobolographic analysis demonstrates additive effect of cisplatin and HDIs combined treatment augmenting their anti-cancer activity in lung cancer cell lines.

Histone deacetylase inhibitors (HDIs) are a new class of drugs which affect the activity of HDACs resulting in changed of acetylation in many proteins. HDIs can induce differentiation, cell growth arrest, apoptosis, inhibit proliferation and angiogenesis in cancer, whereas normal cells are comparatively resistant to the action of HDIs. The aim of this study was to investigate the combined effect of a well-known cytostatic agent-cisplatin (CDDP) and a histone deacetylase inhibitors-either suberoylanilide hydroxamic acid (SAHA, vorinostat) or valproic acid (VPA), on the proliferation of lung cancer cells, as well as induction of apoptosis and inhibition of the cell cycle progression.

Level and conditioning of knowledge about breast cancer displayed by women in perimenopausal age.

Introduction: Women aged 50-69 are the most likely to develop breast cancer. Knowledge about breast tumours as well as regular examination are two of the key factors which reduce the risk of the disease, and increase both the success of treatment and chances of survival.

Objective: The aim of the paper was to assess knowledge about risk factors, symptoms, screening, early diagnosis and breast cancer treatment among women in perimenopausal age.