11,671 results match your criteria: "Medical University of Lublin . Lublin. Poland; aldonkapietrzak3@o2.pl.[Affiliation]"
Proteins
November 2024
Department of Biopharmacy, Medical University of Lublin, Lublin, Poland.
Biased agonism in G protein-coupled receptors is a phenomenon resulting in the selective activation of distinct intracellular signaling pathways by different agonists, which may exhibit bias toward either Gs, Gi, or arrestin-mediated pathways. This study investigates the structural basis of ligand-induced biased agonism within the context of the β-adrenergic receptor (β-AR). Atomistic molecular dynamics simulations were conducted for β-AR complexes with two stereoisomers of methoxynaphtyl fenoterol (MNFen), that is, compounds eliciting qualitatively different cellular responses.
View Article and Find Full Text PDFSci Rep
November 2024
Department of Tissue Engineering and Regenerative Medicine, Medical University of Lublin, Chodzki 1, 20-093, Lublin, Poland.
Hydroxyapatite (HA) granules are frequently used in orthopedics and maxillofacial surgeries to fill bone defects and stimulate the regeneration process. Optimal HA granules should have high biocompatibility, high microporosity and/or mesoporosity, and high specific surface area (SSA), which are essential for their bioabsorbability, high bioactivity (ability to form apatite layer on their surfaces) and good osseointegration with the host tissue. Commercially available HA granules that are sintered at high temperatures (≥ 900 °C) are biocompatible but show low porosity and SSA (2-5 m/g), reduced bioactivity, poor solubility and thereby, low bioabsorbability.
View Article and Find Full Text PDFSci Rep
November 2024
Department of Laboratory Diagnostics, Medical University of Lublin, Doktora Witolda Chodźki 1 Str, Lublin, 20-093, Poland.
Head and neck cancer (HNC) is the seventh most common cancer globally, with 20-60% of patients experiencing nutritional deficiencies. Recent studies indicate that microRNAs (miRNAs) may serve as molecular markers for malnutrition. This study evaluated miR-22-3p as a potential predictor of nutritional deficiencies and a prognostic factor in HNC patients undergoing intensity-modulated radiation therapy (IMRT).
View Article and Find Full Text PDFScand J Trauma Resusc Emerg Med
November 2024
Department of Anaesthesiology and Intensive Care, Medical University of Silesia, Katowice, Poland.
Objective: To indicate factors predicting return of spontaneous circulation in patients with hypothermic cardiac arrest in the pre-rewarming period.
Methods: A multicenter retrospective study was conducted. We included patients who had suffered cardiac arrest caused by severe accidental hypothermia with a core body temperature of ≤ 28 °C.
Hum Immunol
November 2024
Department of Experimental Hematooncology, Medical University of Lublin, Lublin, Poland. Electronic address:
In chronic lymphocytic leukemia (CLL) immune escape mechanism allows leukemia cells to proliferate and expand and it might also be responsible for disease progression. Some molecules involved in the regulation of an immune system might represent prognostic value for CLL patients. Among numerous immune escape mechanisms it was shown that the expression of human leukocyte antigen G (HLA-G) might represent one of the agents damaging cellular immune response.
View Article and Find Full Text PDFCancer Genet
November 2024
Department of Experimental Haematooncology, Medical University of Lublin, Lublin, Poland.
The study aimed to elucidate the mutational profile of patients with newly diagnosed multiple myeloma to understand correlations of alterations with clinical outcomes. A cohort of 20 patients was enrolled, and mutational analysis was conducted using the TruSight Oncology 500 DNA Kit. Identified genetic alterations were related to clinicopathologic features and treatment outcomes.
View Article and Find Full Text PDFPLoS One
November 2024
DOCENTMED Individual Specialist Medical Practice in Lublin, Lublin, Poland.
Background: Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder, whose clinical picture is dominated by visible body changes as well as numerous somatic and behavioural abnormalities.
Aim: The aim of the study was to explore the ways in which the individual experiences NF1 in everyday life, with particular emphasis on the impact of the altered body on family interactions, in addition to the personal and social identity of individuals with NF1.
Methods: A qualitative study was performed using individual in-depth interviews with 93 individuals with NF1 (median age: 36.
BMC Genomics
November 2024
Department of Experimental Hematooncology, Medical University of Lublin, Chodzki 1, Lublin, 20-093, Poland.
Alterations in splicing patterns of leukemic cells have a functional impact and influence most cellular processes since aberrantly spliced isoforms can provide a proliferative advantage, enable to evade apoptosis, induce metabolic reprogramming, change cell signaling and antitumor immune response, or develop drug resistance. In this Review, we first characterize the general mechanism of mRNA processing regulation with a focus on the role of splicing factors, which are commonly mutated in blood neoplasms. Next, we provide a comprehensive summary on the current understanding of alternative splicing events, which confer resistance to targeted treatment strategies and immunotherapy.
View Article and Find Full Text PDFFront Psychiatry
October 2024
Laboratory of Genetics, Academy of Zamość, Zamość, Poland.
Abstract: The study replicates a preliminary report from 2019 on therelationship between body image and persistence.
Purpose: The aim of our study was to analyze the associations between body image, persistence, and body weight stereotypes.
Patients And Methods: A total of 750 individuals were recruited for the study.
RSC Adv
November 2024
Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology Żeromskiego 116 Lodz 90-924 Poland
Two compounds, benzyl-2-(amino(pyrazin-2-yl)methylene)-1-methylhydrazine-1-carbodithioate (L) and its copper(ii) complex Cu(L) were synthesized and studied in terms of their physicochemical properties, including single crystal, spectroscopic and magnetic properties; simulations, including DFT calculations and pharmacokinetic profile analysis; and biological activity. The Cu(L) compound was found to exhibit good anticancer activity against A375, PANC-1, MKN-74, T-47D, HeLa, and NCI-H1563 cells, with the IC value against the HeLa cell line reaching 17.50 μM, significantly surpassing the activity of the organic ligand.
View Article and Find Full Text PDFAdv Clin Exp Med
November 2024
Department of Family and Geriatric Nursing, Faculty of Health Sciences, Medical University of Lublin, Poland.
Background: Insulin resistance (IR) is considered a risk factor for cardiovascular diseases (CVD). Therefore, early diagnosis of IR is clinically significant for primary and secondary CVD prevention initiatives. In addition, non-insulin metabolic indices may be useful for diagnosing IR.
View Article and Find Full Text PDFNeurol Neurochir Pol
November 2024
Department of Neurology, Medical University of Lublin, Lublin, Poland.
Aim Of The Study: The aims of this study were to translate and culturally adapt the Polish version (PL) of the Neuropathic Pain Questionnaire-Short Form (NPQ-SF), as well as to compare this questionnaire to other diagnostic tools in terms of reliability and psychometric validity.
Clinical Rationale For The Study: Neuropathic pain (NP) affects up to 10% of the general population. Despite a large number of studies, almost 50% of patients have a poor therapeutic outcome.
Sci Rep
November 2024
Department of Nursing Fundamentals, Institute of Nursing and Midwifery, Faculty of Health Sciences, Jagiellonian University Medical College, 31-501, Krakow, Poland.
A family with a disabled child has major changes and challenges. The difficulties experienced by the whole family are of various natures and relate to emotional, psychological, caring, and financial problems. The aim of the study is to learn about the challenges and involvement of Polish families in caring for a disabled child in the home environment.
View Article and Find Full Text PDFChest
November 2024
Department of Cardiac and Vascular Diseases, John Paul II Hospital, Krakow, Poland; Pulmonary Circulation Centre, Department of Cardiac and Vascular Diseases, Krakow, Poland. Electronic address:
Background: Current guidelines do not recommend β-blockers in pulmonary arterial hypertension (PAH) unless indicated by comorbidities. However, the evidence regarding the role of β-blockers in PAH is contradictory.
Research Question: What are the effects of β-blockers on clinical outcomes in patients newly diagnosed with PAH, and how do these outcomes differ based on the presence of cardiovascular comorbidities that are standard indications for β-blocker use?
Study Design And Methods: We analyzed data from 806 patients newly diagnosed with PAH enrolled prospectively in the Database of Pulmonary Hypertension in the Polish Population (BNP-PL).
J Neurooncol
January 2025
Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Purpose: Treatment response assessment for gliomas currently uses changes in tumour size as measured with T- and T-weighted MRI. However, changes in tumour size may occur many weeks after therapy completion and are confounded by radiation treatment effects. Advanced MRI techniques sensitive to tumour physiology may provide complementary information to evaluate tumour response at early timepoints during therapy.
View Article and Find Full Text PDFJ Adv Nurs
November 2024
Institute of Sociological Sciences, John Paul II Catholic University of Lublin, Lublin, Poland.
Aim: The study aimed to analyse selected clinical data affecting the quality of life of women with endometriosis.
Design: A cross-sectional study.
Method: The study was conducted in 2020-2022 among 425 women with endometriosis receiving health care.
J Peripher Nerv Syst
December 2024
Takeda Development Center Americas, Inc., Cambridge, Massachusetts, USA.
Background And Aims: Hyaluronidase-facilitated subcutaneous immunoglobulin (fSCIG) consists of subcutaneous human immunoglobulin G (IgG) 10% with recombinant human hyaluronidase (rHuPH20) and can be administered at the same dose and interval as intravenous IgG (IVIG). fSCIG recently received US approval as maintenance therapy for adults with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and European approval for adults and children with CIDP after stabilization with IVIG.
Methods: ADVANCE-CIDP 3 (NCT02955355) was an open-label long-term extension of the Phase 3 double-blind randomized placebo-controlled ADVANCE-CIDP 1 study (NCT02549170) that examined fSCIG safety and efficacy as maintenance CIDP therapy.
Neuropharmacology
January 2025
Department of Functional Anatomy and Cytobiology, Institute of Biological Sciences, Maria Curie-Skłodowska University, Akademicka 19, 20-033, Lublin, Poland. Electronic address:
The most aggressive tumors of human central nervous system are anaplastic astrocytoma (AA, III grade) and glioblastoma multiforme (GBM, IV grade) with an extremely bad prognosis. Their malignant character and resistance to standard therapy are correlated to the over-expression of survival pathways such as Ras/Raf/MEK/ERK and PLCγ1/PKC regulated by TrkB receptor. Therefore, the aim of this study was to investigate the engagement of those pathways in human glioma cells resistance for apoptosis induction by Temozolomide treatment.
View Article and Find Full Text PDFForensic Sci Int Genet
January 2025
Department of Forensic Medicine, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Biogeographical ancestry analysis is valuable in forensic investigations, especially in missing person cases or crimes without eyewitnesses, as it helps to infer geographic origins from genetic markers. This approach enhances forensic efforts by providing essential clues for identifying individuals with limited direct evidence. Slavic-speaking populations are poorly distinguishable based on human genome variability.
View Article and Find Full Text PDFClin Neurol Neurosurg
December 2024
Department of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Poland.
Background: Spinal cord injury caused by stab wounds (SCISW) represents one of the rarest causes of traumatic spinal cord injury. Because of their rarity, management of such cases may be challenging due to the lack of specific guidelines.
Methods: The systematic review was performed on 30th June 2024 according to the PRISMA 2020 guidelines.
Molecules
October 2024
Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), Department of Chemical Sciences, Laboratory of Applied Chemistry, Faculty of Pharmacy, University of Porto, 50-313 Porto, Portugal.
Background: Hypothyroidism (HT) affects millions worldwide and can lead to various lipid disorders. The metabolic complexity and the influence of toxic elements in autoimmune and non-autoimmune HT subtypes are not fully understood. This study aimed to investigate the relationships between plasma lipidome, toxic elements, and clinical classifications of HT in unexposed individuals.
View Article and Find Full Text PDFMolecules
October 2024
Department of Thermal Technology and Food Process Engineering, University of Life Sciences in Lublin, 31 Głęboka St., 20-612 Lublin, Poland.
Studies were conducted focusing on the drying of chili pepper fruits ( L.), cultivar Cyklon, using convective (AD), convective-microwave (AMD), vacuum (VD), and freeze-drying (FD) methods. The influence of the drying method and temperature on the kinetics of the process and selected quality attributes of the dried product were evaluated.
View Article and Find Full Text PDFMolecules
October 2024
Faculty of Medicine, Institute of Medical Sciences, The John Paul II Catholic University of Lublin, 1H Konstantynów Str., 20-708 Lublin, Poland.
One of the challenges of the pharmaceutical and cosmetic industries is to deliver biochemical compounds that can be advantageous for the skin. Research on Boraginaceae taxa has confirmed their use in traditional medicine and proved the potential biological importance of various molecules in cosmetology. The main classes of valuable compounds associated with Boraginaceae taxa are fatty acids, including γ-linolenic acid, essential oils, phenolic acids (e.
View Article and Find Full Text PDFMolecules
October 2024
Department of Analytical Chemistry, Medical University of Lublin, 20-093 Lublin, Poland.
is a valuable plant widely consumed worldwide and considered a rich source of polyphenols. This study examined the impact of the polyphenolic fraction isolated from basil (ObF) on human normal colon epithelial cells and human colorectal adenocarcinoma cells, evaluating its anti-inflammatory and protective activity against oxidative stress. The phytochemical characterization of the fraction was performed using ultra-performance liquid chromatography (UPLC) with a photodiode detector (DAD) and mass spectrometry (MS).
View Article and Find Full Text PDFMolecules
October 2024
Department of Analytical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.
L. is one of the most widely utilized medicinal plants commonly applied in the form of tea, juice, and dietary supplements. This study aimed to assess the effect of the ethanol-water extract (UdE) and polyphenolic fraction isolated from the extract (UdF) on normal human colon epithelial cells and to evaluate their protective activity against induced oxidative stress.
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