Genetic Associations of () and () with Prediabetes in the Ethnic Kazakh Population.

Background: This study aims to investigate the genetic contribution of polymorphic variants of the () and () genes to the risk of developing prediabetes in individuals of Kazakh ethnicity.

Materials And Methods: This was a case-control study involving 200 cases with prediabetes and 200 prediabetes-free controls, aged 16-60 years ( = 400). Real-time polymerase chain reaction on a StepOnePlus instrument (Applied Biosystems, USA), employing the TaqMan method for site-specific amplification and genotyping of the () and () genes was used.

ApoE Gene Polymorphism and Clinical, Biochemical, and Sociodemographic Characteristics of Alzheimer's Disease Patients From Northern and Southern Regions of Kazakhstan.

Background: Alzheimer's disease (AD) is the most frequent cause of dementia in seniors and is also one of the critical social issues of modern healthcare. Since AD is considered a multifactorial disease, the significance of particular risk factors in different ethnic populations is constantly reevaluated.

Method: The study group consisted of 181 patients with AD, and the control group included 244 healthy seniors comparable in sex and age to the dementia group.

The surgical management of penile oleogranuloma: case series.

Oleogranuloma of the penis is a complex set of pathological processes caused by the injection of a foreign substance (gel, balls, rods, etc.) into the penis with the purpose of penile augmentation. In this case series, we investigated a variety of clinical presentations of oleogranuloma and described our experience in managing the complications.

Comparative clinical and placental pathologic characteristics in pregnancies with and without SARS-CoV-2 infection.

Objectives: To compare the clinical and morphological characteristics of the "mother-placenta-fetus" system in high risk pregnant women of three groups: no SARS-CoV-2 infection, mild SARS-CoV-2 infection, and severe SARS-CoV-2 infection.

Methods: A case-control study was performed for all deliveries, at 28 weeks' gestation or greater, who had standard indications for placental pathologic examination. Three groups were formed: (1) control group (no SARS-CoV-2 infection), (2) mild SARS-CoV-2 infection, (3) severe SARS-CoV-2 infection.

Synthesis, Structure and Biological Activity of (1,9)-1н-1,2,3-Triazol-1-yl) Methyl) Octahydro-1-Quinolizine Derivatives of Lupinine.

Lupinine is an elementary representative of a large quinolizidine alkaloid group. Referring to a pharmacological action, lupinin has the bactericidal and low sedative effects. It also possesses the short-term anthelmintic and hypotensive properties.

Genetic markers of the risk of coronary heart disease and coronary artery thrombosis developing in the Kazakh population.

Background: Surgical methods such as coronary artery bypass grafting and percutaneous coronary interventions (PCI) are widely used along with traditional conservative therapy in the treatment of coronary artery disease. The disease outcome directly depends on timely diagnosis and treatment. A significant role in predicting the effectiveness of treatment is given to personification of treatment and management of the patient.

Biological (microfloral) factors of influence on cytogenetic stability during chemical mutagenesis.

The article presents the results of a study of chromosomal mutations in residents living in the Aral Sea disaster zone. The present study was designed to evaluate the impact of the combined effect of a chemical mutagen (nickel) and bacterial microflora on the level of chromosomal aberrations (CA) in peripheral blood lymphocytes. This study used classical methods of cell cultivation, methods for determining chromosomal aberrations, a cytomorphological method for assessing epithelial cells, and an atomic absorption method for determining trace elements in the blood.

[Craniometric aspects in forensic medical identification of the Kazakhstan population].

The aim of this study is to estimate the variability limits of craniometric skull parameters, revealed in Kazakhstan, and find out significant criteria for forensic medical identification of the local population. The investigation included 25 standard craniometric skull parameters, revealed in Kazakhstan. Standard antropometric tests and tools were used.

Inhibition of Acetylcholinesterase by Novel Lupinine Derivatives.

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive memory loss and cognitive impairment due in part to a severe loss of cholinergic neurons in specific brain areas. AD is the most common type of dementia in the aging population. Although several acetylcholinesterase (AChE) inhibitors are currently available, their performance sometimes yields unexpected results.

Synthesis, Properties and Spatial Structure of 4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine.

This article has studied the synthesis of a new derivative of the known alkaloid cytisine contained in the seeds of plants of Cytisus laburnum L. and Thermopsis lanceolata R.Br.

A new approach to designing easily recyclable printed circuit boards.

Due to the ever-increasing amount of electronic waste (e-waste) worldwide, the problem of the effective disposal of printed circuit board waste (WPCB), which are environmentally hazardous, difficult to recycle and economically valuable products, has become a major environmental challenge. Conventional WPCB recycling techniques have low efficiency and require tough processing, such as heat treatment and high pressure. This paper presents a new composite material for the manufacture of printed circuit boards (PCB) that can be easily recycled into their original components and reused.

[Assessment of nutritive status and its correction in oncological patients after operations in the hepatopancreatoduodenal zone].

Surgical interventions in the hepatopancreatoduodenal zone in cancer patients are associated with high risk of nutritional deficiency in the postoperative period. This feature is due to both the volume of the operation itself (pancreatoduodenectomy), and the predominance of catabolic processes in the early postoperative period. In this regard, the monitoring of the main indicators of carbohydrate, protein and fat metabolism in the early postoperative period becomes fundamental for choosing the correct tactics of nutritional support for this patients.

CLINICAL AND GENETIC FACTORS OF CARDIOVASCULAR EVENTS DEVELOPMENT AFTER PERCUTANEOUS CORONARY INTERVENTION.

The new cardiovascular events development remains the main factors limiting its long-term effectiveness despite technological progress and the widespread use of percutaneous coronary intervention (PCI). Objective - to assess the effect of clinical and genetic factors on the development of complication after percutaneous coronary intervention with double antiplatelet therapy (DAT). Case-control.

[The role of the inflammatory process in the development of post-stroke cognitive impairment].

Post-stroke cognitive impairment (PCI) is a common complication of stroke. PCI in most cases is associated with an increased risk of progression to dementia, with a progression rate of 8-15% per year. When post-stroke cognitive impairment reaches dementia, patients lose independence, professional and social maladjustment occurs, which, in turn, significantly worsen the quality of life and reduce the rehabilitation potential.

Bloodstream Infection Etiology among Children and Adults.

Every year in the world, sepsis occurs in 31.5 million people, and the number of deaths reaches 5.3 million per year.

Component Composition and Antimicrobial Activity of CO Extract of , Growing in the Territory of Kazakhstan.

In the medicine of many countries, the use of herbal healing agents included a significant contribution to improving human health and well-being. Many antibiotics have been widely used to treat infectious diseases caused by various pathogenic bacteria. However, increased multidrug resistance has led to increased severity of diseases caused by bacterial pathogens.

[COMPARISON OF DYNAMICS OF LEVEL OF PROCALCITONIN, LIPOPOLYSACCHARIDE BINDING PROTEIN AND INTERLEUKIN-6 IN BLOOD SERUM OF EXPERIMENTAL ANIMALS AT STRANGULATED AND OBTURATIVE INTESTINAL OBSTRUCTION].

The aim of research - to study the level of biomarkers of bacterial translocation in the dynamics of the development of two types of intestinal obstruction. In the experiment, 60 white male rats (2 groups with a model of obstructive (OIO) and strangulated (SIO) intestinal obstruction and the Sham control group) determined the level of biomarkers PCT, LBP, IL-6 in blood serum by ELISA. Statistically significant differences in the levels of PCT and LBP were detected in the subgroups of OIO 1 day and SIO 1h/6h, the maximum values were found in the subgroup of OIO 1 day, with SIO the levels of PCT and LBP gradually increased in the post-reperfusion period.

[METHODS OF VERIFICATION OF THE PHENOMENON OF MICROBIAL TRANSLOCATION IN ACUTE MESENTERIAL ISCHEMIA (REVIEW)].

This article highlights the current problems of studying and diagnosing the phenomenon of bacterial translocation in acute mesenteric ischemia. The urgency of problem is due to high mortality, reaching 60-70% against the background of development of systemic complications. A key element in the development of complications is the phenomenon of microbial translocation.