The Human "Cochlear Battery" - Claudin-11 Barrier and Ion Transport Proteins in the Lateral Wall of the Cochlea.

The cochlea produces an electric field potential essential for hair cell transduction and hearing. This biological "battery" is situated in the lateral wall of the cochlea and contains molecular machinery that secretes and recycles K ions. Its functioning depends on junctional proteins that restrict the para-cellular escape of ions.

Associations between the Application of Signature Character Strengths, Health and Well-being of Health Professionals.

Previous research has shown a positive relation between character strengths, well-being and health. The aim of this analysis was to identify relations between the application of signature character strengths (ASCS) at work, and well-being and health, among medical students (Study 1) and resident physicians (Study 2). We expected positive direct links between the constructs and indirect effects through emotional exhaustion.

The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential.

Temporal lobe epilepsy is considered to be one of the most common and severe forms of focal epilepsies. Patients often develop cognitive deficits and emotional blunting along the progression of the disease. The high incidence of resistance to antiepileptic drugs and a frequent lack of admissibility to surgery poses an unmet medical challenge.

Patterns of Change in Collaboration Are Associated with Baseline Characteristics and Predict Outcome and Dropout Rates in Treatment of Multi-Problem Families. A Validation Study.

The present study validates the Multi-Problem Family (MPF)-Collaboration Scale), which measures the progress of goal directed collaboration of patients in the treatment of families with MPF and its relation to drop-out rates and treatment outcome. Naturalistic study of symptom and competence-related changes in children of ages 4-18 and their caregivers. Integrative, structural outreach family therapy.

Distinguishing Relational Aspects of Character Strengths with Subjective and Psychological Well-being.

Research has shown that character strengths are positively linked with well-being in general. However, there has not been a fine-grained analysis up to date. This study examines the individual relational aspects between the 24 character strengths, subjective well-being (SWB), and different aspects of psychological well-being (PWB) at two times of measurement ( = 117).

The German Version of the Strengths Use Scale: The Relation of Using Individual Strengths and Well-being.

Theoretical perspectives in positive psychology have considered the possession and use of strengths equally but in applied research more studies focused on having them, probably due to the absence of psychometrically adequate scales. Therefore, the aim of this study was to assess the psychometric characteristics of the German language version of the Strengths Use Scale (SUS) and to explore relationships between strengths use and several indicator measures of well-being: the presence of positive and the absence of negative affect, self-esteem as identity aspect, vitality as self-regulatory resource, and stress for capturing the evaluation of difficulties and obstacles impinging on well-being. The original English version of the SUS was translated following recommended independent forward-backward translation techniques.

Effects of Working Memory Capacity and Tasks in Processing L2 Complex Sentence: Evidence from Chinese-English Bilinguals.

Two experiments aimed at investigating how working memory capacity (WMC) related to processing wh-extractions in both a grammatical judgment and a translation task by using the Operation Span task. A self-paced paradigm was used to collect response times and accuracy rates. In Experiment 1, results showed that high WMC was related to faster grammatical judgment of the critical region in subject- and object-extractions.

Genetic and Dietary Iron Overload Differentially Affect the Course of Typhimurium Infection.

Genetic and dietary forms of iron overload have distinctive clinical and pathophysiological features. HFE-associated hereditary hemochromatosis is characterized by overwhelming intestinal iron absorption, parenchymal iron deposition, and macrophage iron depletion. In contrast, excessive dietary iron intake results in iron deposition in macrophages.

Mapping and Identification of Antifungal Peptides in the Putative Antifungal Protein AfpB from the Filamentous Fungus .

Antifungal proteins (AFPs) from Ascomycetes are small cysteine-rich proteins that are abundantly secreted and show antifungal activity against non-producer fungi. A gene coding for a class B AFP (AfpB) was previously identified in the genome of the plant pathogen . However, previous attempts to detect the AfpB protein were not successful despite the high expression of the corresponding gene.

Neurosensory Differentiation and Innervation Patterning in the Human Fetal Vestibular End Organs between the Gestational Weeks 8-12.

Balance orientation depends on the precise operation of the vestibular end organs and the vestibular ganglion neurons. Previous research on the assemblage of the neuronal network in the developing fetal vestibular organ has been limited to data from animal models. Insights into the molecular expression profiles and signaling moieties involved in embryological development of the human fetal inner ear have been limited.