20,172 results match your criteria: "Medical University School[Affiliation]"

Article Synopsis
  • - This research investigates the role of metabolites in Childhood and Juvenile Absence Epilepsy (CAE and JAE) using bidirectional Mendelian randomization to determine causality and mechanisms involved.
  • - A comprehensive analysis of 1,091 blood metabolites revealed significant associations with certain metabolites for CAE (5 identified) and JAE (1 identified), suggesting potential metabolic influences on these epileptic conditions.
  • - The study confirms causal links between specific metabolites and absence epilepsy types while showing no reverse causal relationships, highlighting the integration of genomic and metabolic approaches in understanding epilepsy mechanisms.
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A 71-year-old man with silicosis was treated for infection. Antimycobacterial treatment for was terminated 1 year after a negative test result for the bacteria on sputum examination. One year following the treatment, the patient developed pneumonitis.

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In September 2023, the Japan Society of Pain Clinicians (JSPC) issued this consensus statement on chronic pain treatment in cancer survivors. With recent advances in the early diagnosis and treatment of cancer, its prognosis has improved, so prolonged pain in cancer survivors is considered to represent chronic pain and should be addressed. In this statement, we emphasize that not all cancer survivor pain is cancer pain.

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Objectives: Salivary gland cancer is a rare disease composed of more than 20 histological types with different grades of malignancy. The aim of this multicenter, retrospective study was to identify the most important predictors affecting recurrence and survival after surgery.

Material And Methods: A total of 543 patients with salivary gland cancers that underwent curative surgery between 2012 and 2022 in 13 institutions in northern Japan were evaluated in this study.

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Myxofibrosarcoma (MFS) is one of the most common soft-tissue sarcomas in elderly patients. Owing to the limited efficacy of chemotherapy and radiotherapy, complete resection is the only available curative treatment. Therefore, developing novel therapies for MFS is important to improve clinical outcomes.

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Article Synopsis
  • * The research included 707 adults and found that the 5-year progression-free survival (PFS) rate was 18.8%, with overall survival at 22.0%, and identified key factors affecting outcomes, such as male sex, poor performance status, karyotype risk, and blasts in the blood.
  • * These findings provide valuable insights into the prognosis and treatment strategies for R/R AML, influencing future
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Article Synopsis
  • Peutz-Jeghers syndrome (PJS) and juvenile polyposis syndrome (JPS) are hereditary conditions linked to a high risk of cancer, but their prevalence and incidence in Japan were previously unknown.
  • A nationwide survey in 2022 revealed that there are an estimated 701 patients with PJS and 188 with JPS in Japan, with low prevalence and incidence rates highlighted.
  • Results also showed a higher male representation in both conditions and indicated a need for further research on clinical details and outcomes associated with these syndromes.
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  • - The study evaluated the effectiveness of positron emission tomography feature tracking (PETFT) for measuring endocardial wall strain and compared it with cardiac magnetic resonance-derived feature tracking (CMRFT) in patients with coronary artery disease.
  • - Involving 83 patients, the results showed that PETFT and CMRFT had significant correlations for both resting and stress conditions, indicating reliability in measuring global longitudinal and circumferential strain.
  • - The research concluded that PETFT is a feasible alternative to CMRFT, suggesting its potential use in clinical practice for assessing heart wall strain.
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Spatial Heterogeneity and Risk Factors of Dental Caries in 12-Year-Old Children in Shanxi Province, China.

Biomed Environ Sci

October 2024

Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, Shanxi, China;Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, Shanxi, China.

Article Synopsis
  • The study explored dental caries risk factors in 12-year-old children in Shanxi province, China, focusing on spatial differences and various influencing factors.
  • Data from 3,721 participants across 16 districts were analyzed, considering socioeconomic status, medical resources, and environmental factors using the Geo-detector model.
  • Results showed that socioeconomic factors had the greatest impact on caries prevalence, with urban population percentage being the most influential, while environmental factors like SO2 concentration and water fluoride levels also played significant roles.
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Remineralization and bacterial inhibition of early enamel caries surfaces by carboxymethyl chitosan lysozyme nanogels loaded with antibacterial drugs.

J Dent

January 2025

Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, No.12 Qixiangtai Road, Heping District, Tianjin 300070, PR China; Tianjin Medical University Institute of Stomatology, No.12 Qixiangtai Road, Heping District, Tianjin 300070, PR China. Electronic address:

Objective: This study aimed to develop dual-functional CMC-LYZ-ACP nanogels. Three different antibacterial substances, tea polyphenols (TPs), silver nitrate (AgNO), and chlorhexidine (CHX) are then combined to form three dual-functional CMC-LYZ-ACP nanogels for remineralization and antibacterial purposes.

Methods: An in vitro model of Streptococcus mutans biofilm was established to analyze the inhibitory effect of the antibacterial-remineralizing dual-functional nanogels on the biofilm.

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Article Synopsis
  • - The study investigates psychological birth trauma (PBT) in women during labor, highlighting its common occurrence and significant impact on both maternal and infant health while noting a lack of synthesized data for effective screening and intervention.
  • - A systematic search across several medical databases revealed a pooled prevalence of 19% for PBT, with notable variations based on age, previous birth experience, geographic region, and assessment methods.
  • - Key risk factors identified include fear of childbirth, modes of delivery (like cesarean and operative vaginal births), labor pain, and lack of adequate support from midwives, underscoring the need for tailored healthcare approaches.
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  • The study examines how the preoperative Spine Instability Neoplastic Score (SINS) relates to surgical decisions and patient outcomes in spinal metastases patients.
  • The research involved 317 patients and assessed various factors like surgery type, existing conditions, and postoperative health indicators over 6 months.
  • Findings revealed that SINS did not correlate with life expectancy, all patient-reported outcomes improved post-surgery, and surgical approach (especially fusion vs. non-fusion) didn't significantly impact these outcomes.
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Background: In recent years, the relationship between periodontal disease (PD) and atherosclerosis (AS) has garnered significant scholarly attention. Chronic inflammation induced by PD may promote the onset and progression of AS through multiple mechanisms. Given the increasing global incidence of both PD and AS, which adversely affects patients' quality of life and longevity, further investigation into the interplay between PD and AS is of substantial clinical importance.

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Hypertension increases the risk of cerebrovascular disease and death. In addition to aerobic exercise, which is currently recommended for its antihypertensive effects, recent studies have suggested that dynamic and isometric resistance exercises also have antihypertensive effects. However, the magnitude of the antihypertensive effect of such resistance exercises is not well known.

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Article Synopsis
  • Laparoscopic liver resection (LLR) is challenging and requires skilled scopists, with this study being the first to evaluate their impact on surgical outcomes during the procedure.
  • The study included patients who underwent LLR over five years and categorized scopists into experts (10+ surgeries) and beginners (<10 surgeries) to analyze the effects of their skills on perioperative outcomes.
  • Results showed no baseline differences, but beginner scopists caused significantly longer interruptions during surgery due to errors, suggesting that their lack of experience can increase stress for surgeons and extend operation times.
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Anti-integrin αvβ6 antibody as a biomarker for diagnosing ulcerative colitis: a nationwide multicenter validation study.

J Gastroenterol

November 2024

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: A serum biomarker for diagnosing ulcerative colitis (UC) remains to be established. Although we recently reported an anti-integrin αvβ6 antibody (V6 Ab) for diagnosing UC with high sensitivity and specificity, no large-scale validation study exists. This study aimed to validate the diagnostic value of V6 Ab for UC using a nationwide multicenter cohort study.

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Increased use of electronic devices such as smartphones has led to an increase in neck and shoulder stiffness to the forefront of the public people. It is said that prolonged posture with the head tilted forward causes excessive muscle activity in the head and neck region, resulting in muscle fatigue symptoms such as stiff shoulders. Various bathing methods have been proposed as a means of recovering from muscle stiffness, and in particular, contrast water therapy (CWT) is said to be highly effective in recovering from muscle fatigue.

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has issued eighty papers on Chinese stomatology history in seventy years. According to three stages of the journal,statistics of the quantity and themes of the issued papers are compiled: the number of issued papers increased while the theme shifted from Chinese stomatology history before 1912 to Chinese contemporary stomatology history. Research methods shifted from the comparatively scanty summary or induction on literature and cultural relics materials to multidisciplinary approaches.

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The treatment of the underlying cause of liver disease may potentially reverse hepatic fibrosis. However, it remains uncertain whether improvement in fibrosis can be observed in decompensated liver cirrhosis (LC). Here, we present a case of autoimmune hepatitis (AIH)-related LC in which histological improvement of fibrosis was achieved despite the presence of decompensated LC.

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It is difficult to distinguish idiopathic multicentric Castleman disease (iMCD) from immunoglobulin G4-related disease (IgG4-RD). A 47-year-old man was diagnosed with venous thrombosis in the right lower extremity. Multiple lymphadenopathies and splenomegaly were incidentally detected.

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Comparison of Nonrelapse Mortality After Haploidentical Hematopoietic Stem Cell Transplantation With Post-transplant Cyclophosphamide Versus Single Umbilical Cord Blood Transplantation in Hematologic Disease.

Transplant Cell Ther

November 2024

Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan; Division of Emerging Medicine for Integrated Therapeutics (EMIT), Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan.

Article Synopsis
  • The study compares outcomes of unrelated cord blood transplantation (UCBT) and haploidentical transplantation with posttransplant cyclophosphamide (PTCy-haplo) in patients without a matched donor, focusing on the impact of CD34 cell counts in cord blood.
  • Data from 2014 to 2020 was analyzed, categorizing UCBT cases into those with high (≥0.84 × 10/kg) and low (<0.84 × 10/kg) CD34 cell counts, revealing better neutrophil engraftment in PTCy-haplo compared to both UCB groups.
  • While UCB-H showed similar nonrelapse mortality (NRM) and overall survival
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Article Synopsis
  • Staphylococcus argenteus, a newly identified species, was studied to understand its epidemiology and antibiotic resistance from 2020 to 2023 in northern Japan.
  • The study found 210 S. argenteus isolates, with a slight decrease in their prevalence compared to previous years and identified three genotypes, with ST2250 being the most common.
  • Most isolates were susceptible to tested antibiotics, but one genotype showed higher resistance rates and some non-hemolytic isolates were found to have intact hemolysin genes despite not exhibiting hemolysis.
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Background: Nocturnal home blood pressure monitoring (HBPM) may identify people at higher cardiovascular disease (CVD) risk than expected.

Objectives: The aim of this study was to examine the association between office-masked nocturnal hypertension, defined by HBPM, and CVD risk in a clinical practice-based population.

Methods: Prospective observational study including Japanese high cardiovascular-risk participants.

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