4 results match your criteria: "Medical University Graz Austria.[Affiliation]"
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.
Nat Genet
November 2024
Brain and Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Article Synopsis
- Subcortical brain structures play a crucial role in various developmental and psychiatric disorders, and a study analyzed brain volumes in 74,898 individuals, identifying 254 genetic loci linked to these volumes, which accounted for up to 35% of variation.
- The research included exploring gene expression in specific neural cell types, focusing on genes involved in intracellular signaling and processes related to brain aging.
- The findings suggest that certain genetic variants not only influence brain volume but also have potential causal links to conditions like Parkinson’s disease and ADHD, highlighting the genetic basis for risks associated with neuropsychiatric disorders.
Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.
medRxiv
August 2024
Brain & Mental Health Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.
Article Synopsis
- Subcortical brain structures play a crucial role in various disorders, and a study analyzed the genetic basis of brain volumes in nearly 75,000 individuals of European ancestry, revealing 254 loci linked to these volumes.
- The research identified significant gene expression in neural cells, relating to brain aging and signaling, and found that polygenic scores could predict brain volumes across different ancestries.
- The study highlights genetic connections between brain volumes and conditions like Parkinson's disease and ADHD, suggesting specific gene expression patterns could be involved in neuropsychiatric disorders.
Molar incisor hypomineralization: proportion and severity in primary public school children in Graz, Austria.
Clin Oral Investig
March 2018
University Clinic of Dental Medicine and Oral Health, Division of Prosthodontics, Restorative Dentistry, Periodontology and Implantology, Medical University Graz Austria, Billrothgasse 4, 8010, Graz, Austria.
Objective: The aim of this study was to determine the proportion and severity of molar incisor hypomineralization (MIH) in primary school children in Graz (southeast of Austria).
Materials And Methods: In 1111 children aged 6 to 12 years (mean age 9.0 ± 1.
Reduction of treatment frequency and UVA dose does not substantially compromise the antipsoriatic effect of oral psoralen-UVA.
J Am Acad Dermatol
November 2004
Division of Photodermatology, Department of Dermatology, Medical University Graz Austria.
Background: The carcinogenic potential of 8-methoxypsoralen photochemotherapy (psoralen-UVA [PUVA]) is correlated with the total number of treatments and cumulative UVA dose applied during oral PUVA therapy.
Objective: We sought to determine whether reducing treatment frequency and UVA dose affects the therapeutic efficacy of oral PUVA for patients with chronic plaque psoriasis.
Methods: This was a prospective, randomized, half-side study performed in a photodermatology department in a dermatology hospital.