Treatment of pemphigus vulgaris with mycophenolate mofetil as a steroid-sparing agent.

Pemphigus vulgaris is a rare autoimmune blistering disease. Estimation of the incidence in Iran is one patient per 100,000 of the population per year. Mycophenolate mofetil is an immunosuppressive drug and successful treatment of pemphigus vulgaris and bullous pemphigoid has been reported with it, in combination with high dose prednisone, or as monotherapy.

Flapless implant surgery: review of the literature and report of 2 cases with computer-guided surgical approach.

Purpose: Modern implantology uses techniques that can provide function, esthetics, and comfort with a minimally invasive surgical approach. Flapless implant surgery has been proposed to fulfill these requirements. Traditionally, flapless implant surgery was carried out by using a tissue punch technique, which may be potentially harmful because of the inherent blindness of the technique.

Correction of oral contrast artifacts in CT-based attenuation correction of PET images using an automated segmentation algorithm.

Purpose: Oral contrast is usually administered in most X-ray computed tomography (CT) examinations of the abdomen and the pelvis as it allows more accurate identification of the bowel and facilitates the interpretation of abdominal and pelvic CT studies. However, the misclassification of contrast medium with high-density bone in CT-based attenuation correction (CTAC) is known to generate artifacts in the attenuation map (mumap), thus resulting in overcorrection for attenuation of positron emission tomography (PET) images. In this study, we developed an automated algorithm for segmentation and classification of regions containing oral contrast medium to correct for artifacts in CT-attenuation-corrected PET images using the segmented contrast correction (SCC) algorithm.

Relationship between uterine and ovarian arterial blood flow measured by Doppler sonography at different stages of puberty.

Objective: Measuring blood flow using a special form of color Doppler ultrasonography can help radiologists to identify the stages of development of organs, such as the uterus and ovary. The aim of this study was to determine the relationship between arterial blood flow to the uterus and ovaries at different stages of puberty.

Materials And Methods: Sixty girls referred to the Children's Medical Center in Tehran for the evaluation of pubertal stages were included in the study.

Suppression of telomerase activity by pyrimethamine: implication to cancer.

Background: Although pyrimethamine (Tindurin) appears to be effective in the prevention and treatment of some infectious diseases, very little information exists on its unpredictable properties. We design this study to evaluate its anti-tumoral effect on a model of cell line.

Methods: The cytotoxic influence of Pyrimethamine on prostate cell line was investigated using an in vitro colometric assay.

A theoretical study on interactions between mitoxantrone as an anticancer drug and DNA: application in drug design.

This research is an effort to further understand the physicochemical interaction between the novel drug, mitoxantrone (MTX) and its biologic receptor, DNA. The ultimate goal is to design drugs that interact more with DNA. Understanding the physicochemical properties of the drug as well as the mechanism by which it interacts with DNA, it should ultimately allow the rational design of novel anti-cancer or anti-viral drugs.

Developments in the Field of Conducting and Non-conducting Polymer Based Potentiometric Membrane Sensors for Ions Over the Past Decade.

Many research studies have been conducted on the use of conjugated polymers in the construction of chemical sensors including potentiometric, conductometric and amperometric sensors or biosensors over the last decade. The induction of conductivity on conjugated polymers by treating them with suitable oxidizing agents won Heeger, MacDiarmid and Shirakawa the 2000 Nobel Prize in Chemistry. Common conjugated polymers are poly(acetylene)s, poly(pyrrole)s, poly(thiophene)s, poly(terthiophene)s, poly(aniline)s, poly(fluorine)s, poly(3-alkylthiophene)s, polytetrathiafulvalenes, polynapthalenes, poly(p-phenylene sulfide), poly(p-phenylenevinylene)s, poly(3,4-ethylenedioxythiophene), polyparaphenylene, polyazulene, polyparaphenylene sulfide, polycarbazole and polydiaminonaphthalene.

The nonadrenergic noncholinergic-mediated relaxation of corpus cavernosum was impaired in chronic lithium-treated rats: improvement with l-arginine.

One-third of lithium-treated men complain from sexual dysfunction, although the exact mechanisms of which are not yet known. In this study we investigated the effect of chronic lithium (LiCl, 600 mg/l for 30 days) administration on the neurogenic relaxation of isolated rat corpus cavernosum. The corporal strips were precontracted with phenylephrine and electrical field stimulation (EFS) was applied to obtain relaxation.

Modulation by female sex hormones of the cannabinoid-induced catalepsy and analgesia in ovariectomized mice.

Cannabinoids are psychoactive compounds with many pharmacological properties such as analgesia, sedation and catalepsy most of which are mediated by cannabinoid CB1 receptors. In the present study, we evaluated whether the ovarian sex hormones are involved in the cannabinoid-induced catalepsy and analgesia in ovariectomized female mice. Female NMRI mice (weighing 25-30 g) were divided into 3 main groups: unoperated, sham-operated and ovariectomized.

Sterile water as an irrigating fluid for transurethral resection of the prostate: anesthetical view of the records of 1600 cases.

Objectives: Absorption of the fluid used for bladder irrigation during transurethral resection of prostate (TURP) may disturb the circulatory system and lead to clinical symptoms known as the transurethral resection syndrome. The purpose of this study was to evaluate the changes in electrolytes in patients who had undergone TURP.

Methods: For all the cases with benign prostatic hypertrophy enrolled in the present study, TURP was performed as recommended in Miller's Anesthesia, the sixth edition.

Overexpression of orphan receptor tyrosine kinase Ror1 as a putative tumor-associated antigen in Iranian patients with acute lymphoblastic leukemia.

Receptor tyrosine kinases (RTKs) are a group of enzymes involved in a variety of physiological and pathological processes. The human Ror1 is a member of the RTK family with unknown ligand and biological function. Overexpression of Ror1 has recently been reported in B-cell chronic lymphocytic leukemia.

Recurrent meningitis caused by cervico-medullary abscess, a rare presentation.

Background: Recurrent bacterial meningitis is usually a complication of cranial anatomical defect or the result of impaired humoral immunity, notably, defects of the complement system and agammaglobulinemia. It could present a diverse range of symptoms.

Discussion: Meningitis as a presentation of intramedullary abscess is not common.

Dose-dependent modulation of systemic lipid peroxidation and activity of anti-oxidant enzymes by vitamin E in the rat.

The objective of this work was to examine the time-dependent pro-oxidant versus antioxidant effect of various doses of vitamin E used commonly in experimental studies. Erythrocyte activity of superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT) and plasma lipid peroxidation levels were investigated following biweekly intramuscular administration of 100, 300 and 600 mg/kg of vitamin E at a baseline time point, and additionally at 2, 4 and 6 weeks after initiating treatment. Vitamin E had an antioxidant effect when administered at low doses over short time periods, and increased the activity of antioxidant enzymes.

Asthma in patients with atopic dermatitis.

Objective: This cross-sectional study was designed to estimate the frequency of asthma in patients with atopic dermatitis (AD), and its related factors.

Methods: The study population consisted of 236 patients with AD who were referred to Children Medical Center in 1997-2002 and their diagnosis was based on Hanifin & Rajka criteria. Severity of AD was categorized based on Severity Scoring of Atopic Dermatitis (SCORAD) index.

Schiff's Bases and Crown Ethers as Supramolecular Sensing Materials in the Construction of Potentiometric Membrane Sensors.

Ionophore incorporated PVC membrane sensors are well-established analyticaltools routinely used for the selective and direct measurement of a wide variety of differentions in complex biological and environmental samples. Potentiometric sensors have someoutstanding advantages including simple design and operation, wide linear dynamic range,relatively fast response and rational selectivity. The vital component of such plasticizedPVC members is the ionophore involved, defining the selectivity of the electrodes' complexformation.

Mesothelial/monocytic incidental cardiac excrescence.

Mesothelial/monocytic incidental cardiac excrescence (MICE) is a very uncommon lesion. Diagnosis is incidental and may simulate thrombotic lesions. One of the hypotheses with regard to the etiology of this lesion is a previous cardiac procedure especially mitral valve repair or commissurotomy.

Effects of vitamin D in lung, stomach, esophagus and testis tissues following administration of urethane in balb/c mice.

Objective: To elucidate the role of vitamin D in the histopathological alterations process and K-ras gene mutation exon 1 of tissues including lung, stomach, esophagus, and testis, by the administration of urethane.

Methods: An experimental study in inbred balb/c mice aged 9-11 weeks was designed. This investigation was performed from 2003 to 2005 in the Department of Medical Genetics, Medical Sciences/University of Tehran, Tehran, Iran.

Determination of HLA-B27 subtypes in Iranian patients with ankylosing spondylitis.

The human leukocyte antigen-B27 is one of the class I molecules of the major histocompatibility complex which is strongly associated with ankylosing spondylitis (AS). The strength of the disease association with B27 varies markedly among racial and ethnic populations. It is an allele family, which constitutes about 31 subtypes, with a considerable geographic and ethnic difference in distribution.

Therapeutic effect of sodium alginate in experimental chronic ulcerative colitis.

The aim of this study was to test the therapeutic efficacy of sodium alginate in a rat model of trinitrobenzene sulfonic acid (TNBS)-induced inflammatory bowel disease. This experiment was carried out using 77 Sprague-Dawley rats which were divided into six groups; normal, control, prophylactic, therapeutic and two experimental groups. Rats were sacrificed 1, 2, 3 and 6 weeks after colitis induction.

Bevacizumab-augmented retinal laser photocoagulation in proliferative diabetic retinopathy: a randomized double-masked clinical trial.

Purpose: To evaluate the additional therapeutic effect of single intravitreal bevacizumab injection on standard laser treatment in the management of proliferative diabetic retinopathy.

Methods: A prospective, fellow-eye sham controlled clinical trial was conducted on 80 eyes of 40 high-risk characteristic proliferative diabetic retinopathy type II diabetics. All cases received standard laser treatment according to Early Treatment Diabetic Retinopathy Study protocol.

Listeria monocytogenes activated dendritic cell based vaccine for prevention of experimental tumor in mice.

Background: The use of dendritic cells (DCs) as a cellular adjuvant provides a promising approach in immunotherapy of cancer. It has been demonstrated that Listeria monocytogenes activated DCs pulsed ex vivo with tumor antigens trigger a systemic Th1-biased specific immune response and a single dose of this vaccine will cause a considerable anti tumor immunity.

Objective: The present study was designed to evaluate the ability of multiple doses of tumor antigen-pulsed DCs, matured in the presence of Listeria monocytogenes components in induction of a potent anti-tumor response and the prevention of tumor formation in an experimental model.

Role of Mycobacterium vaccae in the protection induced by first generation Leishmania vaccine against murine model of leishmaniasis.

Various Leishmania antigens showed to induce protection when used with IL-12 as an adjuvant in an animal model of leishmaniasis. Limitations in using IL-12 justify searching for an appropriate adjuvant to accelerate induction of a Th1-type immune response and protection. In this study, the role of Mycobacterium vaccae as an adjuvant mixed with either autoclaved Leishmania major (ALM) or freeze-thawed-killed L.

Novel BTK mutation presenting with vaccine-associated paralytic poliomyelitis.

Oral polio vaccine (OPV) has been used safely and efficiently for more than 40 years in preventive medicine. Vaccine-associated paralytic poliomyelitis (VAPP) is a rare adverse event of OPV due to reversion of the vaccine strain virus to a neurovirulent strain. VAPP can occur in healthy recipients or their close contacts.

The patency rate and complications of polytetrafluoroethylene vascular access grafts in hemodialysis patients: a prospective study from Iran.

The objective of this study was to evaluate the patency rate as well as complications of polytetrafluoroethylene vascular grafts (ePTFE) in patients on hemodialysis (HD). In a prospective study, 84 patients who underwent implantation of vascular grafts for HD at the Sina Hospital, Tehran, Iran, between April 2001 and April 2004, were evaluated. The mean age of the patients was 55 + 12 years; and 42 patients were male.