Efficacy of megestrol acetate (megace) in the treatment of patients with early endometrial adenocarcinoma: our experiences with 21 patients.

Background: There are therapeutic dilemmas regarding fertility-preserving treatment among young women with well-differentiated endometrial carcinoma.

Materials And Methods: Twenty-one patients with stage IA well-differentiated endometrial adenocarcinoma were enrolled in a prospective study. The treatment initiated with 160 mg/d of megestrol acetate.

Correlation between endothelial dysfunction in normal coronary patients with slow flow and aortic ectasia: the first report.

Background: Slow coronary flow (SCF) is slow dye progression in the coronary arteries during selective angiography, but there is no such study about greater visceral vessels. Studies have suggested that flow-mediated dilation (FMD) is impaired in SCF. Endothelial function can be assessed by FMD in the brachial artery as ischemia-induced vasodilation.

Quality of life in opium-addicted patients with coronary artery disease as measured with WHOQOL-BREF.

Objective: Several factors can influence the quality of life in patients with coronary artery disease (CAD). The goal of this research was to measure quality of life in opium-addicted patients with CAD in order to assess the effect of CAD risk factors on their quality of life.

Method: The WHOQOL-BREF questionnaire was completed through interviews with 275 patients who underwent isolated coronary artery bypass surgery in Tehran Heart Centre between May and September 2006.

Diagnostic accuracy of CT scan in abdominal blunt trauma.

Objective: To evaluate the sensitivity and specificity of CT scan findings in patients with blunt abdominal trauma admitted to the university hospital.

Methods: All the patients with blunt abdominal trauma admitted at a tertiary teaching trauma center in Iran between 2005 and 2007 were enrolled in this study. In the absence of any clinical manifestations, the patients underwent a diagnostic CT scan.

Effects of diclofenac epolamine patch on postoperative sore throat in parturients after cesarean delivery under endotracheal general anesthesia.

Background: Postoperative sore throat is a common problem. The efficacy of topical application of non-steroidal anti-inflammatory drugs in alleviating postoperative sore throat has not been established. Our aim was to evaluate the analgesic effects of diclofenac epolamine patch on postoperative sore throat.

Augmentation of bone healing by specific frequency and amplitude compressive strains.

A considerable proportion of bone fractures show signs of delayed or impaired healing. A novel device that applies interfragmentary compressive forces to the fracture site was developed and evaluated for its effect on fracture healing. The midshafts of the right tibias of 16 rabbits were osteotomized, leaving a 2-mm gap.

The prevalence of cagA and cagE genes in Helicobacter pylori strains isolated from different patient groups by polymerase chain reaction.

The aim of this study was to investigate the prevalence of cagA and cagE genes in H. pylori strains isolated from different patient groups with Non-Ulcer Dyspepsia (NUD), Duodenal Ulcer (DU), Gastric Ulcer (GU) and Gastric Cancer (GC). The patients admitted to the gastroenterology unit at Sharyati hospital in Tehran in 2006 were included in this study.

Aortic and mitral valve atherosclerosis: Predictive factors and associations with coronary atherosclerosis using Gensini score.

Background And Aims: Valvular atherosclerosis is defined as extra- and intracellular lipid deposition, thickening of the fibrosa layer, decreased thickness of the spongiosa, and chronic inflammation. We sought to identify the predictive factors for valvular atherosclerosis and assess the possible associations between valvular atherosclerosis and coronary atherosclerosis using the Gensini score.

Methods: Between January 2004 and May 2008, 1400 adult patients underwent mitral or aortic valvular surgery with or without coronary artery bypass grafting (CABG) at our center.

Insulin resistance is an independent correlate of increased urine albumin excretion: a cross-sectional study in Iranian Type 2 diabetic patients.

Aims: To assess the association of insulin resistance with increased urinary albumin excretion (UAE) in a cohort of Iranian Type 2 diabetic patients.

Methods: Three hundred and sixty-one men and 472 women with Type 2 diabetes were enrolled from three different outpatient clinics (Tehran, Iran) during the period 2005-2008. Patients with obstructive uropathy, severe heart failure, liver disease, cancer, autoimmune disease and macroalbuminuria were not included.

Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice.

Cannabinoid system plays a pivotal role in the seizure threshold modulation which is mainly mediated through activation of the cannabinoid CB(1) receptor. There is also several evidence of interaction between cannabinoid system and other neurotransmitters including nitric oxide (NO) system. Using model of clonic seizure induced by pentylenetetrazole (PTZ) in male NMRI mice, we investigated whether NO is involved in the effects of cannabinoids on the seizure threshold.

Brain abscess as a manifestation of spinal dermal sinus.

Dermal sinuses have been associated with a wide spectrum of clinical manifestations ranging from asymptomatic to drainage of purulent material from the sinus tract, inclusion tumors, meningitis, and spinal abscess. To date, there has been no documented report of brain abscess as a complication of spinal dermal sinus. Here, we report an 8-month-old girl who was presented initially with a brain abscess at early infancy but lumbar dermal sinus and associated spinal abscess were discovered afterwards.

Aflatoxin B1 binding capacity of autochthonous strains of lactic acid bacteria.

Some foods are prone to contamination with aflatoxins, with detrimental effect on human health. Lactic acid bacteria have been reported to bind aflatoxins and remove them from foods and feeds. Reduction of aflatoxin B1 (AFB1) from the liquid media by the autochthonous lactic acid bacteria (Lactobacillus casei, Lactobacillus plantarum, and Lactobacillus fermentum) isolated from traditional Iranian sourdough and dairy products is reported in the current study.

A novel approach for repairing of intestinal fistula using chitosan hydrogel.

Intestinal fistula is associated with high morbidity and difficult to manage. Many fistulas require surgical treatment, which usually consists of segmental resection. In this study, using a rat model, the effectiveness of chitosan hydrogel as an intestinal fistula repair agent was investigated.

Effects of body mass index on early outcome of coronary artery bypass surgery.

Aim: Obesity is commonly thought to be a risk factor for morbidity and mortality after cardiac surgery. The aim of the present study is to evaluate the effects of variations in body mass index on in-hospital outcome of coronary artery bypass grafting (CABG).

Methods: The authors conducted a retrospective review of 10191 consecutive patients who had undergone isolated CABG at the center from February 2002 to November 2006.

The Anopheles superpictus complex: introduction of a new malaria vector complex in Iran.

Anopheles superpictus Grassi is one of the most widespread malaria vectors in Iran. Two morphologically independent forms of this mosquito, both at larval and adult stage as well as a great diversity in its mtDNA loci have been previously described in Iran. Because of existence of mtDNA haplotypes, co-occurrence of two forms in diverse climates as well as different roles of populations played in malaria transmission, we hypothesized the possibility of emerging species (or sub-species) within the taxon.

Preparation and in vitro evaluation of mucoadhesion and permeation enhancement of thiolated chitosan-pHEMA core-shell nanoparticles.

The aim of the present work was to evaluate the in vitro mucoadhesion and permeation enhancement properties of thiolated chitosan (chitosan-glutathione) coated poly(hydroxyl ethyl methacrylate) nanoparticles. Core-shell nanoparticles were prepared by radical emulsion polymerization method initiated by cerium(IV) ammonium nitrate. Different molecular weights of chitosan were utilized for nanoparticles preparation.

Is preoperative serum creatinine a reliable indicator of outcome in patients undergoing coronary artery bypass surgery?

Objective: Evaluating renal function by calculating creatinine clearance as an alternative measure to serum creatinine may give a better estimation of postoperative renal function in patients undergoing coronary artery bypass grafting.

Methods: Using our database, we conducted a retrospective review of the records of all 11,884 patients aged 21 years or older undergoing pure bypass grafting who required cardiopulmonary bypass. Preoperative renal function was categorized as normal renal function (serum creatinine View Article and Find Full Text PDF

Design optimization of an above-knee prosthesis based on the kinematics of gait.

A dynamic model of an above-knee prosthesis during the complete gait cycle was developed. The model was based on a two-dimensional multi-body mechanical system and included a hydraulic and an elastic controller for the knee and a kinematical driver controller for the prosthetic ankle. The equations of motion were driven using Lagrange method.

An efficient temperature estimation using optical-flow in ultrasound B-mode digital images.

A two-dimensional temperature estimation method has been proposed based on the detection of shifts in speckle pattern location of ultrasound B-Mode digital images from a region of tissue undergoing thermal therapy. The speckle pattern shifts were due to the local temperature dependence of sound speed and thermal expansion in the heated region. Here in this paper we made use of optical-flow in order to achieve a better accuracy and lower computational burden.

The effects of vacuumic bracing system on the patellofemoral articulation in patients with patellofemoral pain syndrome.

Patellar bracing is a component of treatment of patellofemoral joint (PFJ) problems. A new vacuumic brace was designed by the researchers that act based on an external vacuuming suction. Ten patients were undertaken for the CT scan study at both 0 degrees and 30 degrees knee flexion immediately pre- and post-bracing.

Anticancer effects of HESA-A in patients with metastatic colon cancer.

Background: HESA-A is a natural biological compound of herbal-marine origin. The aim of this study was to investigate the therapeutic effects of HESA-A in patients with metastatic colon cancer.

Methods: Fifty consecutive patients with end-stage colon cancer and liver metastasis at the Cancer Research Center of Tehran University of Medical Sciences were studied.

Immunologic evaluation of patients with recurrent ear, nose, and throat infections.

Purpose: In this study, we aimed to study the frequency of possible underlying immunodeficiency responsible for susceptibility to ear, nose, and throat (ENT) infection.

Materials And Methods: One hundred three (72 males and 31 females) consecutive children and adult patients with history of recurrent or chronic ENT infections, referred by otolaryngologists to the Department of Allergy and Clinical Immunology, Children's Medical Center, Tehran University of Medical Sciences (Tehran, Iran), were enrolled to the study from March 2003 to March 2006. For each patient, demographic information and medical histories of any ENT infections were collected by reviewing the patient's records.

Radio-iodine therapy and Helicobacter pylori infection.

Background: Helicobacter pylori is the most important cause of gastritis and related morbidities. Following consumption, radioactive iodine accumulates considerably in the stomach. On the basis of this observation, we decided to determine whether the high radiation induced by radio-iodine in the stomach is effective in the eradication of this infection.

Helicobacter pylori and esophageal cancer risk: a meta-analysis.

We conducted this meta-analysis to examine the association between Helicobacter pylori and esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma. We searched the PubMed database, the ISI database, and the references of the selected articles. Case-control or nested case-control studies were selected if they used serology or endoscopic methods to detect H.