Co-administration of "L-Lysine, Vitamin C, and Zinc" increased the antioxidant activity, decreased insulin resistance, and improved lipid profile in streptozotocin-induced diabetic rats.

Purpose: We previously showed the beneficial effect of L-Lysine (Lys), a chemical chaperone, on reducing diabetic complications in diabetic rats and type 2 diabetic patients. Herein, we evaluated the effect of Lys co-administration with Vitamin C and Zinc (Lys+VC+Zn), in diabetic rats.

Methods: The streptozotocin (50 mg/Kg) was injected into male adult Wistar rats to induce diabetes.

Oxygen-rich Environment Ameliorates Cell Therapy Outcomes of Cardiac Progenitor Cells for Myocardial Infarction.

To some extent, cell therapy for myocardial infarction (MI) has supported the idea of cardiac repair; however, further optimizations are inevitable. Combined approaches that comprise suitable cell sources and supporting molecules considerably improved its effect. Here, we devised a strategy of simultaneous transplantation of human cardiac progenitor cells (CPCs) and an optimized oxygen generating microparticles (MPs) embedded in fibrin hydrogel, which was injected into a left anterior descending artery (LAD) ligating-based rat model of acute myocardial infarction (AMI).

Computer-assisted horizontal translational osseous genioplasty: a simple method to correct chin deviation.

Background: Different genioplasty techniques are applied for the adjustment of chin area deformities such as chin deviation.

Results: Thirty patients with simple facial asymmetry due to chin deviation underwent computer-assisted horizontal translational osseous genioplasty. In this technique, a surgical guide was used to cut a bone strip from the side where the chin should be transferred to; then, the same bone strip was used for the filling of the gap that was formed on the opposite side.

Vascular endothelial growth factor sustained delivery augmented cell therapy outcomes of cardiac progenitor cells for myocardial infarction.

Cell therapy has become a novel promising approach for improvement of cardiac functional capacity in the instances of ventricular remodeling and fibrosis caused by episodes of coronary artery occlusion and hypoxia. The challenge toward enhancing cell engraftment as well as formation of functional tissue, however, necessitated combinatorial approaches. Here, we complemented human embryonic stem cell-derived cardiac progenitor cell (hESC-CPC) therapy by heparin-conjugated, vascular endothelial growth factor (VEGF)-loaded fibrin hydrogel as VEGF delivery system.

Nutrient pattern of unsaturated fatty acids and vitamin E increase resting metabolic rate of overweight and obese women.

: Obesity plays an important role in the development of chronic diseases including cardiovascular disease and diabetes. A low resting metabolic rate (RMR) for a given body size and composition is a risk factor for obesity, however, there is limited evidence available regarding the association of nutrient patterns and RMR. The aim of this study was to determine the association of nutrient patterns and RMR in overweight and obese women.

Experiences of the mothers of infants hospitalized in the neonatal intensive care unit (NICU).

Background: The mother-newborn relationship is more important in neonates hospitalized in the NICU than in healthy neonates. This study was conducted to explore the experiences of the mothers of infants hospitalized in the NICU.

Materials And Methods: This qualitative study was done in 2016 by adopting a conventional content analysis approach.

A study on sexual functioning in adults with attention-deficit/hyperactivity disorder.

Purpose: Sexual dysfunction has been ignored in adults with attention-deficit hyperactivity disorder (A-ADHD). This study examined sexual function in adults with ADHD compared to a healthy control group.

Design And Methods: The experimental group (N = 63, mean age = 31.

Corrigendum to "Haemodynamic impacts of myocardial bridge length: A congenital heart disease" [Comput. Methods Progr. Biomed., 175 (2019) 25-33].

In this corrigendum, the authors would like to acknowledge the cardiac catheterization laboratory staff at Tehran Heart Center for their assistance in performing the studies under the ethics application TH38-02-2017-20.

Relationship between myocardial bridge compression severity and haemodynamic perturbations.

Objectives: This study aims to examine the alteration in coronary haemodynamics with increasing the severity of vessel compression caused by myocardial bridging (MB).

Methods: Angiography and intravascular ultrasound were performed in 10 patients with MB with varying severities of systolic compression in the left anterior descending (LAD) artery. Computer models of MB were developed and transient computational fluid dynamics simulations were performed to derive distribution of blood residence time and shear stress.

Protective effects of agmatine on doxorubicin-induced chronic cardiotoxicity in rat.

The detrimental cardio-toxic effect of doxorubicin, an effective chemotherapeutic agent, limited its clinical use. It has been claimed that doxorubicin cardio-toxicity occurs through calcium ions (Ca) overload and reactive oxygen species production. Agmatine, an endogenous imidazoline receptor agonist, induce uptake of cytosolic Ca and cause an increase in activity of calcium pumps, including Ca-ATPase.

Evaluation of IGK and IGL molecular gene rearrangements according to the BIOMED-2 protocols for clinical diagnosis of Hodgkin lymphoma.

Background: Although the analysis of molecular clonality rearrangements of the immunoglobulin light chains (IGK and IGL) is an alternative approach for diagnosis of B cell non-Hodgkin lymphomas (NHLs) using BIOMED-2 protocols, NHLs have not been extensively confirmed for Hodgkin lymphoma (HL) cases. We evaluated BIOMED-2 protocols in HL cases, which have been suggested previously as gold standard method for molecular clonality analysis on formalin fixed, paraffin-embedded (FFPE) tissue in NHL patients.

Methods: We recruited 50 consecutive FFPE tissues of HL samples to evaluate IGK and IGL clonality gene rearrangements using BIOMED-2 and Heteroduplex methods.

Partial distal 10q trisomy due to de novo amplification: A new case without furrows or ridges in fingers and palms.

Background: Here we describe a new case of partial distal 10q trisomy in a 6-year-old Iranian girl from healthy parents with mental, growth, and psychomotor retardations.

Methods: Additional clinical features include dysmorphic craniofacial features, microcephaly, bilateral hydronephrosis without heart problems, small and rotated low-set ears, bow-shaped mouth, abnormal teeth, short neck, and as a first case reported, fingers with camptodactly (i.e.

Lipid disturbances before and after renal transplant.

Objectives: Hyperlipidemia is a significant metabolic disorder that is commonly encountered in renal transplant recipients. This study was conducted to investigate lipid disturbances and define its pattern in kidney recipients.

Materials And Methods: The records of 103 patients who had undergone a renal transplant between the years of 2004 and 2005 were retrospectively investigated.

A cytogenetic study of couples with repeated spontaneous abortions.

Background And Objective: The frequency of chromosomal aberrations in Iran is not definitely known. This study determined the frequency of chromosomal aberrations in a series of couples with two or more spontaneous abortions and compared the findings with that reported from other countries.

Methods: This was a descriptive study conducted on 100 couples with recurrent abortions.

Neutrophil function (innate immunity) during Ramadan.

Background: Fasting during the month of Ramadan is one of the essential religious practices of Muslims. The aim of this study was to evaluate opsonisation, phagocytosis, and nitroblue tetrazolium (NBT) reduction by white blood cells in normal, healthy, male subjects under non-fasting (before Ramadan) and fasting (after Ramadan) conditions.

Methods: In this study, 13 Muslim men, aged 28-54 years, whose health was confirmed by health application forms, gave blood samples one week before the beginning of the holy month of Ramadan and during the last week of Ramadan.

Incidence of urinary tract infection in neonates with septicemia: a prospective study.

Aim: The aim of this study was to investigate the incidence and clinical course of urinary tract infection (UTI) in neonates with septicemia and also determine the most common UTI manifestations in hospitalized neonates.

Methods: A cross-sectional study was conducted on consecutive febrile infants aged 1 to 56 days that were hospitalized in the neonatal intensive care unit. In all neonates with positive urine culture, scintigraphy with technetium-99m -labeled dimercaptosuccinic acid (DMSA) and ultrasonography (US) were done.

Behavioral characteristics in 18- to 36-month-old toddlers with atopic dermatitis compared with healthy children.

Some differences in behavioral characteristics have been attributed to atopic dermatitis (AD). In this study, AD patients compared with healthy toddlers had significantly higher scores in perceptual sensitivity and high pleasure in an early childhood behavior questionnaire (ECBQ). They tended to be more energetic and impulsive, and also showed more excitement when subjected to novel stimuli.

Modified flapless dental implant surgery for planning treatment in a maxilla including sinus lift augmentation through use of virtual surgical planning and a 3-dimensional model.

Purpose: The concept of "prosthetic-driven implantology" may be considered a turning point in the history of modern dental implantology. On the basis of this sophisticated approach, the available bone and the optimal prosthetic position of the future restoration are checked before surgical intervention. However, the major drawback of today's prosthodontic discipline is that it is inherently 2-dimensional in nature, which may prevent the appropriate treatment; this problem can be overcome by the 3-dimensional capability of a computer-assisted approach when performed judiciously.

Association of plasma leptin levels and insulin resistance in diabetic women: a cross-sectional analysis in an Iranian population with different results in men and women.

Objectives: The objective of this study was to assess the association of serum leptin levels with insulin resistance (IR), metabolic syndrome (MetS), lipid levels, and glucose control in an Iranian type 2 diabetic population.

Findings: In this cross-sectional analysis, 132 type 2 diabetic patients (79 women) and 71 healthy non-diabetic and non-hypertensive individuals (40 women; as control subjects) were included. Homeostasis model assessment (HOMA) of insulin values ≥ 1.

How to deal with Behcet's disease in daily practice.

Introduction: Behcet's Disease (BD) is classified as a vasculitis, and progresses via attacks and remissions. BD is mainly seen around the Silk Road. The picture varies in different reports.

Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway.

After nearly 60years, lithium is still the mainstay in the treatment of mood disorders. In addition to its antimanic and antidepressant effects, lithium also has anticonvulsant properties. Similar to lithium, agmatine plays a protective role in the central nervous system against seizures and has been reported to enhance the effect of different antiepileptic agents.

Ultrasonographic diagnosis of urinary tract anomalies in neonates: a study among Iranian children.

Aim: The incidence of urinary tract anomalies varies in different population and depends on several factors such as underlying etiologies. The goal of this study was to investigate the incidence of abnormal urinary tract ultrasound findings in children with different etiologies.

Methods: In a case-series study, 100 neonates who were hospitalized in the Children's Hospital Medical Center with the different etiologies such as sepsis, icter, seizure, and respiratory distress were included.

Comparison of atracurium and "mini-dose" succinylcholine for preventing succinylcholine-induced muscle fasciculations: a randomized, double-blind, placebo-controlled study.

Unlabelled: Several drugs have been used to prevent or attenuate succinylcholine- induced muscle fasciculations. There are possible advantages to succinylcholine pretreatment. We designed the present study to compare the effectiveness of atracurium versus "mini-dose" (5 mg) succinylcholine pretreatment for the prevention of muscle fasciculations.

Behcet's disease: from East to West.

Behcet's disease (BD) is classified among vasculitides. There are actually five nationwide surveys of BD: Iran, Japan, China, Korea, and Germany. Among case series, four are on more than 200 cases (Turkey, Morocco, Tunisia, and UK).