2 results match your criteria: "Medical School of Seville[Affiliation]"
Therapeutic efficacy of stable analogues of vasoactive intestinal peptide against pathogens.
J Biol Chem
May 2014
From the Institute of Parasitology and Biomedicine, CSIC, Granada 18016, Spain, the Department of Biochemistry and Molecular Biology, Medical School of Seville, Seville 41009, Spain
Vasoactive intestinal peptide (VIP) is an anti-inflammatory neuropeptide recently identified as a potential antimicrobial peptide. To overcome the metabolic limitations of VIP, we modified the native peptide sequence and generated two stable synthetic analogues (VIP51 and VIP51(6-30)) with better antimicrobial profiles. Herein we investigate the effects of both VIP analogues on cell viability, membrane integrity, and ultrastructure of various bacterial strains and Leishmania species.
View Article and Find Full Text PDFTherapeutic effect of cortistatin on experimental arthritis by downregulating inflammatory and Th1 responses.
Ann Rheum Dis
May 2007
Department of Biochemistry and Molecular Biology, Medical School of Seville, Seville, Spain.
Background: Rheumatoid arthritis is a chronic autoimmune disease of unknown aetiology characterised by chronic inflammation in the joints and subsequent destruction of the cartilage and bone.
Aim: To propose a new strategy for the treatment of arthritis based on the administration of cortistatin, a newly discovered neuropeptide with anti-inflammatory actions.
Methods: DBA/1J mice with collagen-induced arthritis were treated with cortistatin after the onset of disease, and the clinical score and joint histopathology were evaluated.