Metabolomics: Unveiling biological matrices in precision nutrition and health.

Precision nutrition, an expanding field at the intersection of nutrition science and personalized medicine, is rapidly evolving with metabolomics integration. Metabolomics, facilitated by advanced technologies like mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy, facilitates comprehensive profiling of metabolites across diverse biological samples. From the perspective of health care systems, precision nutrition gains relevance due to the substantial impact of prevalent non-communicable diseases (NCDs) on societal well-being, which is directly linked with dietary habits and eating behavior.

Paratesticular sarcomas in Brazil.

Purpose: Paratesticular sarcomas are rare and frequently reported as isolated case reports. Studies evaluating the relative frequency of the paratesticular sarcomas are limited, and to the best of our knowledge, this is the first study of paratesticular sarcomas in the Brazilian population.

Patients And Methods: Medical records of all patients undergoing treatment for paratesticular sarcomas between 1993 and 2006 were retrieved from the archives of our institution.

Testicular metastases: a poor prognostic factor in patients with advanced prostate cancer.

Purpose: Prostate cancer is the most frequently diagnosed neoplasm in men. In some patients, however, the disease pursues a clearly more aggressive course. Testicular metastases from prostate cancer are rare events that have been previously reported; however, its frequency and clinical meaning are not well established.

Relationship between intestinal parasitic infection in children and soil contamination in an urban slum.

Purpose: Urban slums are well known for their high infant mortality and morbidity rates, and parasitic infections seem to be a common problem among these children. The aim of the present study was to determine protozoa and nematodes prevalence among children of a selected community located in São Paulo, Brazil, and access the relation between soil and children infection.

Methods: Soil contamination samples from 15 strategic locations in the slum area as well as stool samples (examined for protozoa and nematodes through five different methods) from 120 children aged 2-14 years (49% M: 51% F, mean +/- SD = 7.

Recreational use of PDE5 inhibitors by young healthy men: recognizing this issue among medical students.

Introduction: In recent years, recreational use of phosphodiesterase type 5 (PDE5) inhibitors has become popular as a sexual enhancement aid among some men without erectile dysfunction (ED) and even among women.

Aim: The aim of the present study, therefore, was to investigate the recreational use of PDE5 among young and healthy men.

Main Outcome Measures: We evaluated the use of PDE5 inhibitors among young and healthy men, their main reasons for using these drugs, and their expectations regarding its effects.

Rapidly induced dopaminergic supersensitivity: D1/D2 receptor participation and its prevention by an MAO-inhibitor.

The dopaminergic system requires combined dopamine D1/D2 receptor stimulation to express its activity; a phenomenon called synergism D1/D2. Dopamine receptors develop supersensitivity following dopamine de-afferentation and/or reserpine treatment. Acute supersensitivity occurs with reserpine treatment.