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High and low molecular weight hyaluronic acid-coated gold nanobipyramids for photothermal therapy.
RSC Adv
February 2018
Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University Nanjing 210002 P. R. China
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. It is known that hyaluronic acid (HA) binds CD44 receptors, which are overexpressed on the surface of TNBC cells. To optimize the targeting ability of HA, in this study we coated gold nanobipyramids (GBPs) with high and low molecular weight HA (380 kDa and 102 kDa), named GBPs@h-HA and GBPs@l-HA, respectively.
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