Propolis-loaded photocurable methacrylated pullulan films: Evaluation of mechanical, antibacterial, biocompatibility, wound healing and pro-angiogenic abilities.

The ultimate goal of this study was to establish the groundwork for the development of high-mechanical pullulan based films for wound healing applications. For this purpose, pullulan (PUL) was successfully methacrylated with different methacrylic anhydride amounts and used for the fabrication of photocurable wound dressing films (PULMA). The mechanical properties of the films, evaluated by changing the methacrylation degree and polymer concentration for better mechanical performance, indicated the best results in terms of elastic modulus (2.

Water-soluble copper(II) 5-fluorouracil complexes bearing polypyridyl co-ligands: synthesis, structures and anticancer activity.

Five newly synthesized copper(II) 5-fluorouracil (5-FU) complexes of polypyridyl co-ligands with good solubility in water, namely [CuCl(5-FU)(bpy)(DMSO)] (1), [Cu(5-FU)(phen)](5-FU)·4HO (2), [Cu(5-FU)(dpya)](NO)·2.5HO (3), [Cu(5-FU)(NO)(bpyma)]·HO (4) and [CuCl(5-FU)(terpy)] (5) (bpy = 2,2'-bipyridine, phen = 1,10-phenanthroline, dpya = 2,2'-dipyridylamine, bpyma = bis(2-pyridylmethyl)amine and terpy = 2,2';6',2''-terpyridine), were characterized by elemental analysis and a number of spectrometric methods. The structures of complexes 1-5 were determined by X-ray crystallography and the copper(II) ions were five coordinate.

A prospective and comparative investigation of blood sFlt-1, P1GF, and niacin concentrations in women with premature ovarian insufficiency.

Objective: Endothelial dysfunction is an important component of preeclampsia like premature ovarian insufficiency (POI), and it is reported that placental growth factor (P1GF) and soluble fms-like tyrosine kinase receptor-1 (sFlt-1) levels are important in preeclampsia. Extra-placental sources for P1GF and sFlt-1 have also been identified, including various cell types. In animal models of POI, niacin treatment inhibited follicular apoptosis under hazardous conditions while significantly reducing cumulus cell apoptosis.

Highly Promising Antitumor Agent of a Novel Platinum(II) Complex Bearing a Tetradentate Chelating Ligand.

A new mononuclear cationic platinum(II) coordination compound with 6,6'-bis(NH-benzimidazol-2-yl)-2,2'-bipyridine () ligand having N-tetradentate binding pocket [Pt()]Cl·2HO () was synthesized and characterized by FT-IR(ATR), UV-vis, H NMR, APCI and MALDI MS, and CHN analysis. The antigrowth effect of was tested in breast cancer (MDA-MB-231), lung cancer (A549), colorectal cancer (HCT-116), prostate cancer (PC-3) cell lines, and bronchial epithelial cell line (BEAS-2B) by the SRB and ATP cell viability assays. Apoptosis was detected with Annexin V, mitopotential, BCL-2 inactivation, and γH2AX assays by flow cytometry.