67 results match your criteria: "Medical School of Duke University[Affiliation]"
Psych J
October 2024
Centre for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, Durham, North Carolina, USA.
Psych J
October 2024
Centre for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, Durham, North Carolina, USA.
The effects of tea consumption on delaying aging and the onset of age-related disabilities have been reported; however, it is unclear whether these benefits are impacted by genes. This study aimed to examine the associations between tea consumption and activities of daily living (ADL) and explore the role of genetic factors. Data from 46,487 older adults aged 64-105 who participated in at least one data wave of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) conducted in 2002, 2005, 2008, 2011, 2014, and 2018 were analyzed.
View Article and Find Full Text PDFJ Gerontol A Biol Sci Med Sci
September 2024
Center for Healthy Aging and Development Studies, National School of Development, Peking University, Beijing, China.
Background: To enhance the precision of measuring, analyzing, and forecasting care needs for older adults with physical and/or mental disabilities, we developed the Physical Disability Index (PDI) and Mental Disability Index (MDI). Furthermore, we evaluated the reliability and validity of the PDI and MDI. Additionally, we investigate their associations with falls to further indicate the predictive validity.
View Article and Find Full Text PDFEnviron Res
July 2024
China Center for Health Development Studies, Peking University, Beijing, China; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China. Electronic address:
Background: Previous research has shown that lack of leisure activities, either outdoor or social activities, impedes cognitive function. However, the interrelationship between poor cognition and deficient activities is understudied. In addition, whether exposure to air pollution, such as PM, can accelerate the detrimental 'inactivity-poor cognition' cycle, is worthy of investigation.
View Article and Find Full Text PDFHeliyon
January 2024
The First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China.
PNAS Nexus
December 2023
Vanke School of Public Health, Tsinghua University, Beijing 100084, China.
The winter heating policy in northern China was designed to safeguard households from the harsh subfreezing temperatures. However, it has inadvertently resulted in seasonal spikes in air pollution levels because of the reliance on coal as an energy source. While the loss of life years attributable to mortality from air pollution caused by winter heating has been estimated, the beneficial effect of protection from cold temperatures has not been assessed, primarily due to a lack of individual-level data linking these variables.
View Article and Find Full Text PDFN Engl J Med
October 2023
The authors' affiliations are as follows: the Center for Population Health Innovation, University Heart and Vascular Center Hamburg (C.M., F.M.O., T.L., R.T., J.W., A.Z., S.B.), University Medical Center Hamburg-Eppendorf (C.M., F.M.O., T.L., R.T., J.W., A.Z., S.B.), the German Center for Cardiovascular Research (DZHK) Partner Site Hamburg-Kiel-Lübeck (C.M., T.L., R.T., J.W., S.B.), the Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, and Network Aging Research, Heidelberg University, Heidelberg (H.B., B.S.), the Department of Internal Medicine B, University Medicine Greifswald, and DZHK Partner Site Greifswald, Greifswald (M.D.), DZHK Partner Site Munich Heart Alliance (W.K., A. Peters), the German Heart Center, Technical University of Munich (W.K.), and the Institute for Medical Information Processing, Biometry, and Epidemiology, Medical Faculty, Ludwig Maximilians Universität München (A. Peters, B.T.), Munich, the Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm (W.K.), the Institute of Clinical Chemistry and Laboratory Medicine (K.J.L.), Preventive Cardiology and Preventive Medicine (P.S.W.), and Clinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis (P.S.W.), University Medical Center of the Johannes Gutenberg-University Mainz, DZHK Partner Site Rhine-Main (K.J.L., P.S.W.), and Institute for Molecular Biology (P.S.W.), Mainz, the University Heart and Vascular Center Frankfurt, DZHK Partner Site Rhine-Main, Frankfurt (D.M.L.), the Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (A. Peters, B.T.), and German Center for Diabetes Research (DZD) Partner Site Munich-Neuherberg (A. Peters, B.T.), Neuherberg - all in Germany; the Department of Medicine (Cardiology), McMaster University, Hamilton, Canada (D.P.L.); the Experimental Medicine Research Unit, School of Medicine, National Autonomous University of Mexico, Mexico City (J.A.-D.), and Centro de Estudios en Diabetes, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca (C.G.) - both in Mexico; Université de Lille, INSERM, Centre Hospitalier University de Lille, Institut Pasteur de Lille, UMR1167-RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Epidemiology and Public Health Department, Lille (P.A.), the Department of Cardiology, INSERM UMR1295, Toulouse Rangueil University Hospital, Toulouse (J.F.), and the Department of Public Health, Strasbourg University Hospital, University of Strasbourg, Strasbourg (M.M.) - all in France; the Division of Clinical and Health Services Research, National Institute on Minority Health and Health Disparities (L.A.-S.), and the Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (M.N.), National Institutes of Health, Bethesda, MD; the Department of Public Health and Primary Care, Ghent University, Ghent, Belgium (D.D.B.); the Department of Medicine, Baylor College of Medicine (C.M.B.), and Michael E. DeBakey Veterans Affairs Hospital and Baylor College of Medicine (V.N.), Houston, and the Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (J.L.) - all in Texas; the CRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru (A.B.-O., J.J.M.); the Department of Epidemiology and Public Health (M.B.) and the Research Department of Primary Care and Population Health (S.G.W.), University College London, London, the Centre for Public Health, Queens University Belfast, Belfast (F.K.), and the Cardiovascular Epidemiology Unit, Institute of Cardiovascular Research, University of Dundee, Dundee (H.T.-P.) - all in the United Kingdom; the Emory Global Diabetes Research Center and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta (R.M.C.-L.); the School of Public Health, University of Queensland, Brisbane (A.D.), the Division of Cancer Epidemiology, Cancer Council Victoria (A.M.H.), the Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, the University of Melbourne (A.M.H.), and Baker Heart and Diabetes Institute (J.E.S.), Melbourne, the Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney (J.J.M.), and the George Institute for Global Health (A.E.S.), Sydney, and the School of Population Health (A.E.S.), University of New South Wales, Kensington (L.A.S.) - all in Australia; the Department of Cardiovascular and Endocrine-Metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome (C.D., L.P.), the Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese (M.M.F., L.I., G.V.), the Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli (G. de Gaetano, L.I.), Clinica Medica, University of Milano-Bicocca, Milan (G. Grassi), and the MONICA (Monitoring Cardiovascular Diseases)-Friuli Study Group, Udine (D.V.) - all in Italy; the Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, National Institute of Cardiology, and Lazarski University, Warsaw (W.D.), and the Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow (A. Pajak) - all in Poland; the Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen (R.P.D.), and the Departments of Neurology (M.K.I.) and Epidemiology (M.K.I., M.K.), Erasmus University Medical Center Rotterdam, Rotterdam - both in the Netherlands; the Department of Clinical Sciences Malmö, Lund University, Malmö (G.E., O.M.), the Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University (U.R.), and the Department of Medical Sciences, Uppsala University, Uppsala (L.L.), and the Department of Public Health and Clinical Medicine, University of Umea, Umea (S. Söderberg) - all in Sweden; the Department of Epidemiology, Tel Aviv University School of Public Health, Tel Aviv, Israel (U.G.); HUNT (Trøndelag Health Study) Research Center, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger (K.H.), the K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Trondheim(K.H.), the Department of Cardiology, Division of Medicine, Akershus University Hospital, Lørenskog (M.N.L.), the K.G. Jebsen Center for Cardiac Biomarkers, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo (M.N.L.), and the Department of Clinical Medicine, University of Tromsø the Arctic University of Norway, Tromsø (E.B.M.) - all in Norway; the Department of Chronic Diseases, Institute for Clinical Effectiveness and Health Policy, Buenos Aires (V.I.); Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine, Banjul, Gambia (M.J., A.M.P.); the Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki (P.J., K.K., V.S.); Medical Research Council-Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda (P.K., J.M.); the Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences (D.K.), the Liver and Pancreaticobiliary Disease Research Center (R.M.), the Digestive Oncology Research Center (R.M., H.P.), and the Digestive Disease Research Center (R.M., M.N., H.P., S.G.S.), Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences - all in Tehran, Iran; the National Research Center for Therapy and Preventive Medicine, Ministry of Healthcare of the Russian Federation, Moscow (A.K.), and the Research Institute of Internal and Preventive Medicine-Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk (S.M.) - both in Russia; the Department of Clinical Medicine, Faculty of Health and Medical Sciences (A.L.), and the Department of Cardiology, Bispebjerg Hospital (E.P.), University of Copenhagen, and the Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital (A.L.) - both in Copenhagen; the Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia (A.M.); the Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka (T.N., S. Sakata), and the Global Center of Excellence Program Study Group, Yamagata University School of Medicine, Yamagata (M.W.) - both in Japan; the School of Medicine, University of Passo Fundo, Passo Fundo (K.O.), and the Department of Public Health, Postgraduate Program in Public Health, Federal University of Santa Catarina, Florianopolis (E.O.) - both in Brazil; the School of Health Sciences and Education, Harokopio University, Athens, Greece (D.P.); the National Council of Applied Economic Research, Delhi (A. Perianayagam), and the International Institute for Population Sciences, Mumbai (A. Perianayagam) - both in India; the Catalan Department of Health, Barcelona (S. Sans); the Hypertension in Africa Research Team, South African Medical Research Council Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom (A.E.S.), and the School of Mathematics, Statistics, and Computer Science, University of KwaZulu-Natal, Pietermaritzburg (A.Z.) - both in South Africa; the Department of Internal Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Nepal (S.K.S.); the Laboratory of Population Studies, Institute of Cardiology, and the Department of Preventive Medicine, Faculty of Public Health, Lithuanian University of Health Sciences, Kaunas, Lithuania (A.T.); the China Center for Health Development Studies (Y.Y.) and Center for Healthy Aging and Development Studies, National School of Development (Y.Z.), Peking University, and the Key Laboratory of Epidemiology of Major Diseases, Peking University, Ministry of Education (Y.Y.) - both in Beijing; the Center for the Study of Aging and Human Development and Geriatrics Division, Medical School of Duke University, Durham, NC (Y.Z.); and Cardio-CARE, Davos (A.Z., S.B.), and the Swiss Institute of Bioinformatics, Lausanne (A.Z.) - both in Switzerland.
Background: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.
Methods: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium.
J Hazard Mater
July 2023
China Center for Health Development Studies, Peking University, Beijing, China; Center for Healthy Aging and Development Studies, National School of Development, Peking University, Beijing, China. Electronic address:
Background: Cohort evidence linking long-term survival with exposure to multiple air pollutants (e.g., fine particulate matter [PM] and ozone) was extensively sparse in low- and middle-income countries, especially among older adults.
View Article and Find Full Text PDFHeliyon
February 2023
Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
Background: Depressive disorder is a common comorbidity in patients with cardiovascular diseases and is associated with increased hospitalization and death rates. The relationships between cardiac structure and function and depressive disorder remains unclear in the older adults, especially in centenarians. Therefore, this study aimed to explore the possible associations between cardiac structure and function and depressive disorder among centenarians.
View Article and Find Full Text PDFNutrients
December 2022
Department of Nephrology, Hainan Hospital of Chinese PLA General Hospital, Hainan Province Academician Team Innovation Center, Sanya 572013, China.
This longitudinal cohort study explored the associations of 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), and β-C-terminal telopeptide of type 1 collagen (β-CTX) levels with all-cause mortality in centenarians. The study included 952 centenarians (81.4% female).
View Article and Find Full Text PDFHeliyon
December 2022
Department of Cardiology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, China.
Objectives: Depression is a common disease of elderly population, with a global prevalence of more than 20%. Few studies have involved the associations of constipation and overeating with depression, especially in the elderly population. We aimed to address these associations in Chinese oldest-old and centenarians.
View Article and Find Full Text PDFJ Inflamm Res
December 2022
Department of Cardiology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, People's Republic of China.
Purpose: Age related cognitive function (ARCF) is of increasing concern in an aging population. Few studies have examined the relationships between ARCF and antibody expression or blood pressure, particularly in older populations. Large sample sizes are needed to elucidate these relationships to inform better strategies for identification and prevention of cognitive decline.
View Article and Find Full Text PDFInt J Med Sci
November 2022
Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
The nonreceptor tyrosine kinase c-Abl is inactive under normal conditions. Upon activation, c-Abl regulates signaling pathways related to cytoskeletal reorganization. It plays a vital role in modulating cell protrusion, cell migration, morphogenesis, adhesion, endocytosis and phagocytosis.
View Article and Find Full Text PDFEnviron Int
November 2022
Vanke School of Public Health, Tsinghua University, Beijing, China. Electronic address:
Vitamin D metabolism is essential in aging and can be affected by multiple environmental factors. However, most studies conducted single exposure analyses. We aim to assess the individual and combined effects of ultraviolet (UV) radiation, residential greenness, fine particulate matter (PM), and ozone (O) on vitamin D levels in a national cohort study of older adults in China.
View Article and Find Full Text PDFBiol Psychiatry
May 2023
Department of Neurology and Institute of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:
Background: Air pollution induces neurotoxic reactions and may exert adverse effects on cognitive health. We aimed to investigate whether air pollutants accelerate cognitive decline and affect neurobiological signatures of Alzheimer's disease (AD).
Methods: We used a population-based cohort from the Chinese Longitudinal Healthy Longevity Survey with 31,573 participants and a 10-year follow-up (5878 cognitively unimpaired individuals in Chinese Longitudinal Healthy Longevity Survey followed for 5.
J Transl Med
July 2022
Department of Cardiology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, China.
Background: Physical independence is crucial for overall health in the elderly individuals. The life expectancy of women has been shown to be higher than that of men, which is also known as the "male-female health-survival paradox". Sex hormones may be one of the explanations.
View Article and Find Full Text PDFAging Cell
July 2022
BGI-Shenzhen, Shenzhen, China.
Front Cardiovasc Med
May 2022
Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
Coronavirus disease 2019 (COVID-19) is a highly contagious disease. Most infected patients manifest mild flu-like symptoms, but in some cases, the patients rapidly develop severe lung infections and pneumonia. It is estimated that about 15-20% of patients with COVID-19 develop hypoxemia and require some form of oxygen therapy and ventilation support.
View Article and Find Full Text PDFNutrients
May 2022
Center for Healthy Aging and Development Studies, National School of Development, Peking University, Beijing 100871, China.
Investigations on gender variations in the risk factors of cognitive impairment are required to promote future precision medicine among older adults, as well as to contribute to a better understanding of the "male-female health-survival paradox". With this study, we aimed to investigate the effects of "diet-smoking-gender" three-way interactions on cognitive impairments among Chinese older adults. We conducted a 16-year prospective cohort study among 15,953, 15,555, 16,849, 9716, 7116, and 13,165 older adults from the 2002, 2005, 2008-2009, 2011-2012, 2014, and 2017-2018 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), respectively.
View Article and Find Full Text PDFImmun Ageing
May 2022
Department of Cardiology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, China.
Background: Depression is considered to be an immune-related disease; however, previous studies have focused on inflammatory factors, and there is no conclusive conclusion on the relationships between immunoglobulins and depression. Therefore, the objective of this cross-sectional study was to evaluate the associations between immunoglobulins and depressive symptoms in Chinese older adults.
Results: The China Hainan Centenarian Cohort Study (CHCCS) provides a significant population-based sample of older adults in Hainan, China.
Front Aging Neurosci
February 2022
Global Health Research Center, Duke Kunshan University, Kunshan, China.
Recent literature suggested that mutation is associated with alcohol metabolism, and ethanol intake might jointly increase the risk of Alzheimer's disease (AD) in mice. However, it is unclear whether this synergistic effect exists among humans. We examined the associations of four single nucleotide polymorphisms (SNPs) on aldehyde dehydrogenase () and alcohol dehydrogenase () genes (i.
View Article and Find Full Text PDFNat Aging
March 2022
School of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
A plant-based dietary pattern has been recommended for its potential health and environmental benefits, but its relation to mortality warrants further exploration. We examined this association among 13,154 adults aged 65 years and older (57.4% female) in the Chinese Longitudinal Healthy Longevity Survey (CLHLS).
View Article and Find Full Text PDFAging (Albany NY)
November 2021
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China.
Genes related to human longevity have not been studied so far, and need to be investigated thoroughly. This study aims to explore the relationship among ABO gene variants, lipid levels, and longevity phenotype in individuals (≥90yrs old) without adverse outcomes. A genotype-phenotype study was performed based on 5803 longevity subjects and 7026 younger controls from the Chinese Longitudinal Healthy Longevity Survey (CLHLS).
View Article and Find Full Text PDFFront Aging Neurosci
September 2021
Center for Healthy Aging and Development Studies at National School of Development, Peking University, Beijing, China.
Both leisure activities and the ε4 allele of the apolipoprotein E ( ε4) have been shown to affect cognitive health. We aimed to determine whether engagement in leisure activities protects against ε4-related cognitive decline. We used the cohort data from the Chinese Longitudinal Healthy Longevity Survey.
View Article and Find Full Text PDFJ Am Med Dir Assoc
December 2021
Central Laboratory, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, China.