56 results match your criteria: "Medical School of Anhui Medical University[Affiliation]"
Exosomes from MiR-30d-5p-ADSCs Reverse Acute Ischemic Stroke-Induced, Autophagy-Mediated Brain Injury by Promoting M2 Microglial/Macrophage Polarization.
Cell Physiol Biochem
July 2018
Department of Neurology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, China.
Background/aims: Recent studies have indicated that exosomes secreted from adipose-derived stem cells (ADSCs) have important effects in the treatment of ischemic injury. However, the treatment mechanism is unclear. This study aimed to investigate whether ADSC-derived exosomes enriched with microRNA (miR)-30d-5p have a protective effect on acute ischemic stroke (AIS).
View Article and Find Full Text PDFDownregulation of circ_008018 protects against cerebral ischemia-reperfusion injury by targeting miR-99a.
Biochem Biophys Res Commun
May 2018
Department of Neurology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai 200135, PR China. Electronic address:
Article Synopsis
- CircRNAs, specifically circ_008018, are found to be highly expressed in the brain during cerebral ischemia-reperfusion injury, suggesting a potential role in regulating damage.
- Knocking down circ_008018 in mice reduced brain damage and neurological deficits by promoting the overexpression of microRNA miR-99a.
- The study indicates that inhibiting circ_008018 could help protect the brain from damage caused by ischemia-reperfusion injury, revealing new mechanisms behind apoptosis in this context.
Long Noncoding RNA H19 Promotes Proliferation and Invasion in Human Glioma Cells by Downregulating miR-152.
Oncol Res
October 2018
Department of Neurosurgery, 101st Hospital of PLA (Wuxi Taihu Hospital), Clinical Medical School of Anhui Medical University, Wuxi, P.R. China.
miR-152 and lncRNA H19 have been frequently implicated in various cellular processes including cell proliferation, invasion, angiogenesis, and apoptosis. However, the interaction between miR-152 and H19 in glioma has never been reported. RT-qPCR was used to examine the expression of miR-152 and H19 in human glioma cell lines and normal human astrocytes (NHAs).
View Article and Find Full Text PDFPrognostic Value of the Expression of DNA Repair-Related Biomarkers Mediated by Alcohol in Gastric Cancer Patients.
Am J Pathol
February 2018
Department of Oncology, First Affiliated Hospital of Anhui Medical University, Hefei, China. Electronic address:
Alcohol consumption likely induces gastric carcinogenesis through deregulation of RNA polymerase (Pol) III genes and oxidative damage. Transcription factor IIB-related factor 1 (BRF1) overexpression alleviates RNA Pol III transcription inhibition through breast cancer susceptibility gene 1 (BRCA1). Myeloperoxidase (MPO) involvement in cancer is induced by alcohol-mediated oxidative damage.
View Article and Find Full Text PDFAtorvastatin ameliorates early brain injury after subarachnoid hemorrhage via inhibition of AQP4 expression in rabbits.
Int J Mol Med
April 2016
Department of Neurosurgery, l01st Hospital of PLA (Wuxi Taihu Hospital), Clinical Medical School of Anhui Medical University, Wuxi, Jiangsu 214044, P.R. China.
The therapeutic effects of atorvastatin on early brain injury (EBI), cerebral edema and its association with aquaporin 4 (AQP4) were studied in rabbits after subarachnoid hemorrhage (SAH) using western blot analysis and the dry-wet method. Seventy-two healthy male New Zealand rabbits weighing between 2.5 and 3.
View Article and Find Full Text PDFEffect of mild hypothermia on the increase of CD11b+ Gr-1+ myeloid-derived suppressor cells induced by lipopolysaccharide in a mouse model of sepsis.
Am J Emerg Med
October 2015
Department of Emergency, Clinical College of Pediatrics, Anhui Medical University, Anhui Provincial Children's Hospital, Hefei, China. Electronic address:
Purpose: This study aimed to investigate the influence of mild hypothermia on the number of CD11b+ Gr-1+ myeloid-derived suppressor cells (MDSCs) induced by lipopolysaccharide (LPS) injection in mice with sepsis.
Methods: BALB/c mice were administered LPS to establish a mouse model of sepsis. Then, these mice were randomly divided into 3 groups: the mild hypothermia plus LPS group, the normothermia plus LPS group, and the LPS group.