Assessment of Buccal Bone Surrounding Dental Implants Using a High-Frequency Ultrasound Scanner.

The purpose of this study was to determine the buccal bone dimensions surrounding dental implants using a high-frequency ultrasound (US) scanner and cone-beam computed tomography (CBCT). Dental implants (n = 10) inserted in the maxilla of dry skulls were scanned using US (28 MHz, bandwidth 84%, aperture 6 mm, focal depth 13.2 mm) and CBCT (70 kV, 6.

Impression of Subgingival Dental Preparation Can Be Taken with Ultrasound.

Because of its ability to capture hard structures behind soft tissue, ultrasound-based micro-scanning may be a promising alternative for taking digital impressions of teeth, especially in the case of subgingival margin preparations. The aim of this study was to assess the accuracy of ultrasound impressions taken of subgingivally prepared teeth compared with digital optical impressions. Ten extracted human teeth (7 pre-molars, 3 molars) were prepared for crowns with chamfer finish line and then digitized using two different intra-oral scanners (Cara Trios, 3 Shape, Heraeus Kulzer, Hanau, Germany; and Lava COS; 3M ESPE, Seefeld, Germany) and one extra-oral scanner (Cares CS2, Straumann, Basel, Switzerland).

Accuracy of single crowns fabricated from ultrasound digital impressions.

Objective: This in vitro study aimed to evaluate marginal and internal fit of single crowns produced from high-frequency ultrasound based digital impressions of teeth prepared with finish lines covered by porcine gingiva, in comparison with those obtained by optical scanners with uncovered finish lines.

Methods: Ten human teeth were prepared and forty zirconia crowns were fabricated from STL-datasets obtained from four dental scanners (n=10): extraoral CS2 (Straumann), intraoral Lava COS (3M), intraoral Trios (3Shape) and extraoral ultrasound scanner. The accuracy of the crowns was compared evaluating marginal and internal fit by means of the replica technique with measurements in four areas; P1: occlusal surface; P2: transition between occlusal and axial surfaces; P3: middle of axial wall; and P4: marginal gap.

Implant Placement under Existing Removable Dental Prostheses and the Effect on Follow-Up and Prosthetic Maintenance.

Purpose: The aim of this prospective clinical study was to compare the maintenance interventions required for solely implant-retained overdentures (I-OD) with that of overdentures retained by a combination of telescopic crowns and implants (T/I-OD).

Materials And Methods: The participants in this study were 22 patients who initially presented either with a removable complete denture (n = 11) or with an overdenture retained by 1 to 2 telescopic crowns on natural teeth (n = 11). Subsequently, the total number of abutments was increased to 5 to 6 (maxilla) or 4 to 5 (mandible) by placing implants in strategically advantageous regions, generating two distinct groups: I-OD and T/I-OD.

Male-to-female gender dysphoria: Gender-specific differences in resting-state networks.

Introduction: Recent research found gender-related differences in resting-state functional connectivity (rs-FC) measured by functional magnetic resonance imaging (fMRI). To the best of our knowledge, there are no studies examining the differences in rs-FC between men, women, and individuals who report a discrepancy between their anatomical sex and their gender identity, i.e.

Analysis of tooth preparations for zirconia-based crowns and fixed dental prostheses using stereolithography data sets.

Statement Of Problem: Under clinical circumstances, it can be challenging for a dentist to achieve an adequate tooth preparation, which is essential for the long-term success of fixed dental restorations. This is particularly true for zirconia restorations fabricated by computer-aided design and computer-aided manufacturing (CAD-CAM) because of the difficulties involved in the scanning and milling process.

Purpose: The purpose of this retrospective study was to use a digital approach to evaluate dental tooth preparations for zirconia-based crowns and fixed dental prostheses (FDP) performed by general dental practitioners in Germany and to find out whether the type of prepared tooth or the type of restoration influenced the outcome.

Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation.

The inflammatory response involves a complex interplay of different cytokines which act in an auto- or paracrine manner to induce the so-called acute phase response. Cytokines are known to crosstalk on multiple levels, for instance by regulating the mRNA stability of targeted cytokines through activation of the p38-MAPK pathway. In our study we discovered a new mechanism that answers the long-standing question how pro-inflammatory cytokines and environmental stress restrict immediate signalling of interleukin (IL)-6-type cytokines.

Recombinant bovine uteroglobin at 1.6 A resolution: a preliminary X-ray crystallographic analysis.

Uteroglobin (UG) is a conserved protein which is induced by progesterone and secreted by the epithelia of various mammalian reproductive and respiratory organs. Recombinant bovine uteroglobin (recbUG), consisting of 80 amino acids with a C-terminal His6 tag, was overexpressed in Escherichia coli and purified. The protein was crystallized in two geometric forms, rhomboid and cuneate (wedge-shaped), by the hanging-drop vapour-diffusion method at 295 K.

The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling.

Signalling of interleukin (IL)-6 and interleukin-11 through gp130 homodimeric receptor complexes has been analysed with respect to initiation and termination of signalling in great detail. Gp130 contains a crucial motif around tyrosine Y759, which mediates negative regulation through the feedback inhibitor SOCS3 and the protein tyrosine phosphatase SHP2. Signalling of leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), CT-1-like factor (CLC) or oncostatin M (OSM) through gp130/LIF-R is believed to be similar due to the presence of the common signal transducer gp130 within the receptor complexes utilized, but the difference in the composition of gp130/gp130-homodimers and gp130/LIF-R-heterodimers is likely to be reflected in different signalling.

Expression, function and clinical relevance of MIA (melanoma inhibitory activity).

Despite its ambiguous name the protein melanoma-inhibitory-activity (MIA) was identified as a key molecule involved in progression and metastasis of malignant melanomas. Therefore, in this review we intend to update the current knowledge on expression patterns, transcriptional regulation, function and clinical relevance of MIA. Furthermore, we will cover the recently discovered MIA homologous proteins OTOR/MIAL, MIA 2 and TANGO.