2,327 results match your criteria: "Medical School Hannover[Affiliation]"

Pulmonary veno-occlusive disease (PVOD) is a lethal variant of pulmonary hypertension. The degree of pulmonary arterial involvement varies. Here, we compare two PVOD patients who were transplanted at 8 years of age, whereof one is a homozygous mutation carrier.

View Article and Find Full Text PDF

Genotype and Associated Cancer Risk in Individuals With Telomere Biology Disorders.

JAMA Netw Open

December 2024

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

Article Synopsis
View Article and Find Full Text PDF

Background: Patients with neuromuscular knee instability who are fitted with orthotic devices experience issues such as pain, falls, mobility limitations, and restricted participation.

Objectives: To analyze the burden of disease in patients using a microprocessor-stance-and-swing-control orthosis (MP-SSCO) and, if they had a previous orthosis, to compare their outcomes to those with previous use of a traditional knee-ankle-foot-orthosis (KAFO) under real-world conditions.

Methodology: A structured cross-sectional survey was conducted in six orthotic and prosthetic clinics in Germany.

View Article and Find Full Text PDF

Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19.

Cell Host Microbe

December 2024

Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Koç University, School of Medicine, İstanbul, Turkey. Electronic address:

Article Synopsis
View Article and Find Full Text PDF

Introduction: Monitoring kidney function and immunosuppressant levels in children post-kidney transplantation or those with glomerulopathies is challenging due to frequent venipunctures and clinic visits. Capillary dried blood spot sampling (DBS) offers a potential alternative.

Methods: In this prospective single-center study, 89 children (38% female and 62% male) requiring therapeutic drug monitoring (TDM) and kidney function assessment were enrolled.

View Article and Find Full Text PDF

Background/aim: Biomarkers for patients suffering from glioblastoma (GBM) are scarce. Extracellular vesicles (EV) are a promising candidate for a potential biomarker. Therefore, EV concentration could be a potential biomarker of tumor burden, volume, and prognosis.

View Article and Find Full Text PDF

Impact of cannabinoids on synapse markers in an SH-SY5Y cell culture model.

Schizophrenia (Heidelb)

October 2024

Laboratory of Molecular Neurosciences, Department of Clinical Psychiatry, Medical School Hannover, Hanover, Germany.

Patients suffering from schizophrenic psychosis show reduced synaptic connectivity compared to healthy individuals, and often, the use of cannabis precedes the onset of schizophrenic psychosis. Therefore, we investigated if different types of cannabinoids impact methylation patterns and expression of schizophrenia candidate genes concerned with the development and preservation of synapses and synaptic function in a SH-SY5Y cell culture model. For this purpose, SH-SY5Y cells were differentiated into a neuron-like cell type as previously described.

View Article and Find Full Text PDF

TNBC-DX genomic test in early-stage triple-negative breast cancer treated with neoadjuvant taxane-based therapy.

Ann Oncol

October 2024

West German Study Group, Monchengladbach, Germany; Breast Center, Department of Obstetrics and Gynecology and CCC Munich, LMU University Hospital, Munich, Germany.

Background: Identification of biomarkers to optimize treatment strategies for early-stage triple-negative breast cancer (TNBC) is crucial. This study presents the development and validation of TNBC-DX, a novel test aimed at predicting both short- and long-term outcomes in early-stage TNBC. The objective of this study was to evaluate the association between TNBC-DX and efficacy outcomes [pathologic complete response (pCR), distant disease-free survival (DDFS) or event-free survival (EFS), and overall survival (OS)] in the validation cohorts.

View Article and Find Full Text PDF

Background: Emerging evidence suggests that endovascular thrombectomy is beneficial for treatment of childhood stroke, but the safety and effectiveness of endovascular thrombectomy has not been compared with best medical treatment. We aimed to prospectively analyse functional outcomes of endovascular thrombectomy versus best medical treatment in children with intracranial arterial occlusion stroke.

Methods: In this prospective registry study, 45 centres in 12 countries across Asia and Australia, Europe, North America, and South America reported functional outcomes for children aged between 28 days and 18 years presenting with arterial ischaemic stroke caused by a large-vessel or medium-vessel occlusion who received either endovascular thrombectomy plus best medical practice or best medical treatment alone.

View Article and Find Full Text PDF
Article Synopsis
  • Acute Type A aortic dissection (ATAAD) with supra-aortic branch (SAB) malperfusion is a serious condition that often leads to high mortality, but the use of the Aortic Arch Modular Device System (AMDS) offers innovative stabilization and management options.
  • A case study of a 63-year-old male patient with severe acute chest pain due to ATAAD demonstrated the effectiveness of the AMDS, enabling successful aortic arch reconstruction and addressing malperfusion issues post-surgery.
  • The findings suggest that AMDS represents a significant advancement in the treatment of ATAAD, allowing for less invasive procedures and improving outcomes through the integration of advanced endovascular techniques.
View Article and Find Full Text PDF

The acquisition of subsequent genetic lesions (clonal evolution, CE) and/or the expansion of existing clones (CEXP) contributes to clonal dynamics (CD) in myelodysplastic syndromes (MDS). Although CD plays an important role in high-risk patients in disease progression and transformation into acute myeloid leukemia (AML), knowledge about CD in lower-risk MDS (LR-MDS) patients is limited due to lack of robust longitudinal data considering the long clinically stable courses of the disease. In this retrospective analysis, we delineate the frequency and the prognostic impact of CD in an unselected real-world cohort of LR-MDS patients.

View Article and Find Full Text PDF
Article Synopsis
  • Salvage radiation therapy (sRT) is crucial for patients who experience biochemical recurrence after prostate surgery, and a new nomogram has been developed to predict their chances of remaining free from this recurrence.
  • * This study aims to evaluate the effectiveness of PSMA-PET-based assessments in guiding sRT for cases of prostate-specific antigen (PSA) persistence or recurrence, and it seeks to improve predictive models using random survival forests compared to traditional Cox models.
  • * Data from 1029 patients across five countries were analyzed to validate these predictive models, utilizing machine learning techniques to better understand outcomes related to biochemical failure after treatment.
View Article and Find Full Text PDF

Background: Safety recommendations for Janus kinase inhibitors (JAKi) issued by the European Medical Agency (EMA) in 2023 could potentially influence treatment patterns for rheumatoid arthritis (RA) drugs, but little is known about the impact of these recommendations in routine clinical care.

Methods: We retrospectively analyzed the German RHADAR rheumatology database for adult patients with RA and documentation of a new therapy with a JAKi, tumor necrosis factor inhibitor (TNFi), or interleukin-6 receptor inhibitor (IL-6Ri). Data were grouped into half-yearly intervals from quarter (Q)2/2020 to Q3/2023.

View Article and Find Full Text PDF

Immune checkpoint inhibitors are standard-of-care for the treatment of advanced melanoma, but their use is limited by immune-related adverse events. Proteomic analyses and multiplex cytokine and chemokine assays from serum at baseline and at the adverse event onset indicated aberrant T cell activity with differential expression of type I and III immune signatures. This was in line with the finding of an increase in the proportion of CD4 T cells with IL-17A expression at the adverse event onset in the peripheral blood using flow cytometry.

View Article and Find Full Text PDF

Understanding the endogenous mechanism of adaptive response to drug-induced liver injury (arDILI) may discover innovative strategies to manage DILI. To gain mechanistic insight into arDILI, we investigated exosomal miRNAs in the adaptive response to toosendanin-induced liver injury (TILI) of mice. Exosomal miR-106b-5p was identified as a specific regulator of arDILI by comprehensive miRNA profiling.

View Article and Find Full Text PDF
Article Synopsis
  • The akinetic crisis is a severe, potentially life-threatening condition in Parkinson's disease characterized by extreme rigidity and akinesia that does not respond to levodopa, often accompanied by high fever and altered consciousness.
  • Although akinetic crises are rare, milder forms of motor deterioration in Parkinson's patients frequently lead to hospitalizations, highlighting the broader spectrum of akinetic symptoms.
  • The review explores clinical symptoms, risk factors, diagnostic methods like DAT-SPECT for assessing levodopa-resistance, and discusses the role of inflammatory cytokines in progression, along with guidelines for managing these conditions.
View Article and Find Full Text PDF

Objectives: In 2022, the Biliary Atresia and Related Diseases (BARD) community reached a consensus for the definition of suspected and confirmed cholangitis for biliary atresia (BA) patients after hepatoportoenterostomy (HPE). This study assessed the new standardized BARD definition in a retrospective, multicenter cohort study.

Methods: We included BA cases managed between 2010 and 2020 at the Hannover Medical School and Geneva University Hospitals' Swiss Pediatric Liver Center.

View Article and Find Full Text PDF

Efficacy and safety of palliative treatment in patients with autoimmune liver disease-associated hepatocellular carcinoma.

Ann Hepatol

October 2024

Department of Internal Medicine and Gastroenterology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany; European Reference Network on Hepatological Diseases (ERN RARE-LIVER).

Article Synopsis
View Article and Find Full Text PDF

Prevalence, severity, and predictors of self-reported depression in ultra-distance runners: An online survey based on 265 athletes.

Injury

November 2024

Institute of Biomechanics and Neuroscience, Nordic Science, Hannover, Germany; Department of Psychiatry, Social Psychiatry and Psychotherapy, Medical School Hannover, Hannover, Germany. Electronic address:

Article Synopsis
  • * Female ultra-runners reported higher depression rates (30.8%) compared to males (16.2%), while those without previous sports injuries and older runners demonstrated lower risks of depression symptoms.
  • * The results emphasize the necessity for mental health screening in ultra-runners, particularly among those with injuries, challenging previous assumptions about the sport's unique characteristics concerning mental health.
View Article and Find Full Text PDF