6 results match your criteria: "Medical Research and Educational Institute[Affiliation]"

Objective: To evaluate the representation and localization of FAP-positive activated stromal cells depending on the severity of fibrotic changes in tissues of patients with a confirmed diagnosis of COVID-19.

Material And Methods: 20 autopsy observations of patients who died from COVID-19 were studied. Immunohistochemical studies were performed using antibodies to CD90, FAP and aSMA and a dual imaging system.

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Article Synopsis
  • The study aimed to identify why patients with chronic heart failure (CHF) in Russia have a poor prognosis, using data from various population samples and medical records over several years.
  • It established the prevalence of CHF in the Russian population, finding that 8.2% of individuals meet soft criteria for CHF, while 3.1% met strict criteria, with significant influences from conditions like hypertension and ischemic heart disease.
  • The prognosis for these patients is grim, with over half dying within four years after acute decompensated heart failure (ADHF), and most patients with severe CHF not surviving beyond ten years, primarily due to inadequate medication use and poor patient follow-up.
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  • The CHANCE study investigated the effects of a monitoring and education program for patients with chronic heart failure, comparing an intervention group (IG) receiving structured support to a control group (CG) receiving standard care.
  • Results showed that the IG had significantly lower mortality rates (8.3%) compared to the CG (13.0%), and a relative risk of 0.68 for death, indicating the program's effectiveness in saving lives.
  • Additionally, the IG exhibited better improvements in clinical condition, functional capabilities (as seen in the 6-minute walk test), and overall quality of life, with significant reductions in anxiety and depressive symptoms over 12 months.
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  • * To achieve this goal, the SEHF developed comprehensive Guidelines for CHF and conducted various registries and multicenter clinical trials (MCTs) over 25 years.
  • * The article highlights key registries and MCTs that have significantly improved CHF therapy and diagnostics among physicians in the Russian Federation.
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Pericarditis as an inflammatory heart disease is rarely discussed in the cardiology community. The latest European guidelines on pericarditis were published in 2015, and Russian clinical guidelines are dated 2022. However, in recent years, a number of publications have appeared that have forced the scientific community to take a fresh look at this problem.

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