Production of TNF-alpha, IL-6 and TGF-beta, and expression of receptors for TNF-alpha and IL-6, during murine Mycobacterium avium infection.

The Mycobacterium avium complex comprises intracellular bacteria associated with disseminated infection in patients with acquired immune deficiency syndrome (AIDS). Immune defects that lead to infection are unknown but cytokines appear to play an important role in the immunomodulation of host defence mechanisms. We evaluated the cytokine profiles seen temporally after murine M.

The relationship of alcohol use to sexual activity in a U.S. national sample.

Recent reports have indicated that the use of alcohol is related to sexual behavior (such as unprotected intercourse) that is high-risk for HIV infection. However, most of these studies have collected data from convenience samples, using measures of varying specificity. This paper describes a study designed to investigate the relationship of alcohol use to unsafe sexual activity in a representative sample of adults.

Use of liposome preparation to treat mycobacterial infections.

Infections caused by organisms of the genus mycobacteria, such as tuberculosis M. avium disseminated infection in AIDS patients and leprosy, are extremely common around the world. Mycobacteria are intracellular organisms that invade and multiply chiefly within phagocytic cells.

Sexual behavior of American adolescents: results from a U.S. national survey.

Purpose: This paper reports on data from a 1990 U.S. national survey of the sexual behavior of male and female adolescents aged 12-17.

Dysfunctional monocytes from a patient with disseminated Mycobacterium kansasii infection are activated in vitro and in vivo by GM-CSF.

A 27 year-old woman presented with disseminated infection due to Mycobacterium kansasii. Signs and symptoms of disseminated infection persisted despite the administration of multiple antimycobacterial agents to which her organism was sensitive for 15 months. She was seronegative for HIV-1 and functional studies of T and B lymphocytes and granulocytes failed to demonstrate any abnormality.

Infection of murine macrophages with Toxoplasma gondii is associated with release of transforming growth factor beta and downregulation of expression of tumor necrosis factor receptors.

Toxoplasma gondii is capable of invading and multiplying within murine peritoneal macrophages. Previous studies have shown that treatment of macrophage monolayers with recombinant gamma interferon but not tumor necrosis factor (TNF) is associated with intracellular killing of T. gondii by macrophages.

The sexual behavior of US adults: results from a national survey.

Objectives: One consequence of the acquired immunodeficiency syndrome (AIDS) epidemic has been to highlight the need for population-based estimates of the number of individuals engaging in sexual behaviors that place them at risk for human immunodeficiency virus (HIV) infection. This paper describes the prevalence of various sexual behaviors in a nationally representative sample of adults in the United States.

Methods: Data were collected as part of a household probability survey of adults (n = 2058) in the United States.

Timing of the breath analyzer: does it make a difference?

The purpose of this article is to examine in an emergency room (ER) population the concordance of self-reports of no alcohol consumption prior to injury with breath-analyzer readings in two groups: (1) those patients from whom reports were obtained after they were breath analyzed compared to (2) patients from whom reports were obtained prior to obtaining the breath-analyzer reading. Data were collected on a probability sample of patients attending three health maintenance organization ERs. Among those sampled were 159 patients admitted for initial treatment of an injury, who were breath analyzed within 6 hours of the event and reported no drinking following the event that lead to injury.

Drinking in the injury event: a comparison of emergency room populations in the United States, Mexico, and Spain.

Variables related to drinking in the injury event were compared among probability samples of emergency room patients in Contra Costa County, California (N = 1,001), Mexico City (N = 1,688) and Barcelona, Spain (N = 1,684). Drinking companions and places of drinking prior to injury, place of injury associated with drinking, amount of alcohol consumed, proximity of drinking with the injury event, perceived drunkenness at the time, and causal attribution of drinking with the event were all found to vary among the samples. The data suggest that the context in which alcohol is involved in the injury event is affected by the context in which alcohol is typically consumed in a culture and is important in analyzing alcohol's role in injury occurrence and situations which may be considered high-risk for alcohol-related injuries.

Alcohol, injury, and risk-taking behavior: data from a national sample.

The association of alcohol consumption and injury is well documented in the literature. It has also been suggested that alcohol consumption is associated with risk-taking behaviors. No studies have reported the association of alcohol consumption and risk-taking behaviors with injury across all injury types, however.

Alcohol consumption among emergency room patients: comparison of county/community hospitals and an HMO.

This study examines the associations of drinking patterns and problems to injury vs noninjury status among emergency room (ER) patients. Data come from two distinctly different health care systems in the same county: (1) the county hospital and three community hospitals (N = 2,626) and (2) the three health maintenance organization (HMO) hospitals (N = 1,102). Results indicate that alcohol's role in injury cases seen in the ER differs from its contribution to noninjury cases.

Alcohol and drug problems among diverse health and social service populations.

Objectives: This study responds to clinical and research interest in identifying alcohol- and drug-related problems in health and social service agency populations. These problems are associated with a variety of illnesses and social problems, and community agencies serve important screening functions.

Methods: Indicators of problematic alcohol and drug use are compared across representative samples of clients within a county's alcohol, mental health, and drug treatment systems; hospital emergency rooms; primary health clinics; criminal justice and welfare systems; and general population.

The association between severity of DSM-III-R alcohol dependence and medical and social consequences.

This paper describes the relationship between severity of dependence and medical and social consequences in a clinical sample. Respondents constitute a sample of 219 men and 162 women interviewed in nine alcohol programs in a Northern California county. Results suggest that the number of dependence indicators reported by respondents is a valid indicator of severity of alcohol dependence, and that there is a positive relationship between the number of indicators and the number of medical and social consequences reported by respondents.

Prediction of alcohol-related casualties in the emergency room: a U.S.-Spain comparison.

Alcohol consumption variables predictive of casualties are compared in probability samples of emergency room (ER) patients in two countries with different drinking patterns; (1) Spain, where frequent light drinking is the typical pattern (N = 2,072), and (2) the U.S. (i.

Alcoholics anonymous, other 12-step movements and psychotherapy in the US population, 1990.

Based on the 1990 US National Alcohol Survey, this note provides the first available comprehensive findings on self-reported utilization of a variety of sources of personal support and counselling for alcohol and other problems. Respondents were queried about lifetime attendance and number of times they went to identified sources of help in the prior year. Twelve-step groups included Alcoholics Anonymous, Al-Anon, Adult Children of Alcoholics, and other non-alcohol-oriented groups like Gamblers Anonymous, Narcotics Anonymous, and Overeaters Anonymous; additional questions inquired about support or therapy groups and individual counselling for non-alcohol problems.

Unsafe sexual behavior and alcohol use at the event level: results of a national survey.

In recent years, several researchers have suggested that the use of alcohol in conjunction with sexual activity significantly increases the probability that unsafe or risky sexual behavior will occur. However, the majority of studies examining this relationship have utilized general measures of drinking frequency and sexual behavior, and are therefore unable to establish whether the drinking and risky sex occur on the same occasion. In this study, adult respondents in a national survey were asked about the circumstances of two sexual encounters: their most recent sexual experience and their most recent encounter involving a new sexual partner.

Production of transforming growth factor-beta by Mycobacterium avium-infected human macrophages is associated with unresponsiveness to IFN-gamma.

Transforming growth factor-beta 1 (TGF-beta 1) is a potent immunoregulatory molecule. It modulates production of cytokines, such as TNF-alpha and IL-6, and cell response to cytokine stimulation. Mycobacterium avium is an intracellular bacterium that multiplies within macrophages.

Differential mechanisms of intracellular killing of Mycobacterium avium and Listeria monocytogenes by activated human and murine macrophages. The role of nitric oxide.

Murine peritoneal macrophages activated with interferon-gamma (IFN-gamma) produce large quantities of nitric oxide and are efficient in the killing of certain intracellular pathogens. To examine the role of this mechanism in the killing of Mycobacterium avium by murine and human macrophages, we infected mouse peritoneal macrophages and human monocyte-derived macrophages with M. avium and Listeria monocytogenes and stimulated the cells with recombinant tumour necrosis factor (TNF), granulocyte-macrophage colony-stimulating factor (GM-CSF) or IFN-gamma, in the presence or absence of N-monomethyl-L-arginine (NMA) or arginase.

Alcohol and violence-related injuries: an emergency room study.

Drinking patterns, alcohol-related problems and drinking-in-the-injury event were compared between those admitted to the emergency room (ER) with and without injuries resulting from violence. A probability sample of 1770 adult casualty patients in four hospitals in a single California suburban county were breathalyzed and interviewed at the time of the ER visit. Among all males and females over 30, those with violence-related injuries were more likely than those with other injuries to have positive breathalyzer readings and to report drinking prior to the event, frequent heavy drinking, consequences of drinking, experiences associated with alcohol dependence and loss of control and prior treatment for an alcohol problem.

Drinking patterns and problems: a comparison of ER patients in an HMO and in the general population.

The purpose of this study was to compare drinking patterns and alcohol-related problems and associations of these variables with casualties in an emergency room (ER) population and in the general population from which these patients come. A probability sample of patients seen in all three health maintenance organization (HMO) hospital ERs in one U.S.

Self-control concerns and drinking loss of control in general and clinical populations.

In popular conceptions, loss of control over drinking involves a double loss of control, over one's life as well as over one's drinking. A measure of "control worries," concerning the experience of difficulties in controlling one's life, was developed. The relationships between measures of control worries, loss of control over drinking and heavy-drinking behavior were examined in samples both of alcohol treatment clients and of the general population in a California county.

Operational definitions of alcohol dependence and associated factor structures.

This paper examines the impact of three different operational definitions of alcohol dependence on analyses of the factor structure of that concept. Data came from a sample of 219 men interviewed while in treatment for alcohol problems. The first operational definition was created with 20 items previously used in the literature and which are thought to represent the elements of dependence in the DSM-III-R criteria.

Postantibiotic effect of amikacin and rifapentine against Mycobacterium avium complex.

Postantibiotic effect (PAE) has received little attention in the therapy of chronic intracellular infections, such as those caused by mycobacteria. Amikacin is active therapeutically against Mycobacterium avium complex, even though serum levels exceed the MIC for only a few hours. To determine the PAE of amikacin and rifapentine for M.

First effects of warning labels on alcoholic beverage containers.

Health warning labels are now required on alcoholic beverage containers in the United States. This study addresses who has seen these labels and respondents' reported changes in relevant knowledge, attitudes and behavior. Random samples of adults in the general population of the United States were interviewed by telephone 6 months prior to and 6 months after the enactment in November 1989 of the warning label law (N = 2006 and 2000, respectively).

Interleukin-6 antagonizes tumor necrosis factor-mediated mycobacteriostatic and mycobactericidal activities in macrophages.

Interleukin-6 (IL-6) is a cytokine produced by a number of cells, including macrophages, and is directly involved in the inflammatory response. The production of IL-6 can be stimulated by monokines such as IL-1 and tumor necrosis factor (TNF). Mycobacterium avium complex organisms frequently cause disseminated disease in patients with AIDS.